Drug Discovery and Delivery NEtwork for ONcology and Eye Therapeutics

Resultado final

Gene Editing Technology for Drug Screening Report

Report reviewing exchange of knowledge in utilising gene editing technology to generate disease models for drug screening

Use of In Vivo Mammalian Models of Ocular Drug Efficacy/Safety Report

Report reviewing exchange of knowledge in relation to use of in vivo mammalian models of ocular drug efficacysafety

Development of Novel PDX Cancer Models Report

Report reviewing exchange of knowledge regarding development of novel PDX models of cancer

Exploitation of Fungal Resources in Drug Discovery and Drug Metabolism Report

Report reviewing exchange of knowledge in relation to relevance of fungi for drug discovery and drug metabolism studies

Dossier of Best Management Practices

Executive summary and dossier of reflective reports into best management practices to adopt

Zebrafish as Toxicology Screening Model Report

Reports reviewing exchange of knowledge regarding relevance of zebrafish as toxicology screening model

3D-animations to enhance awareness (Cancer and Blindness)

Generation of 3D-animations to enhance awareness of the significance of cancer & blindness.

Launch of 3D-NEONET Website and Social Media

Establishment of 3D-NEONET website and social media interfaces

Initiation of 3D-NEONET Secondments

Initiation of 3D-NEONET Secondment Programme

DMP

Data Management Plan

Publicaciones

Species Mixing Proportion and Aridity Influence in the Height–Diameter Relationship for Different Species Mixtures in Mediterranean Forests

Autores: Diego Rodríguez de Prado, Jose Riofrío, Jorge Aldea, James McDermott, Felipe Bravo and Celia Herrero de Aza
Publicado en: Forests, Edición 19994907, 2022, ISSN 1999-4907
Editor: MDPI Open Access Publishing
DOI: 10.3390/f13010119

Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases

Autores: José Javier López-Cano, Sigen A., Vanessa Andrés-Guerrero, Hongyun Tai, Irene Bravo-Osuna, Irene Teresa Molina-Martínez, Wenxin Wang, Rocío Herrero-Vanrell
Publicado en: Pharmaceutics, Edición 13/2, 2021, Página(s) 234, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020234

Fungal and Bacterial Communities in Tuber melanosporum Plantations from Northern Spain

Autores: Celia Herrero de Aza, Sergio Armenteros, James McDermott, Stefano Mauceri, Jaime Olaizola, María Hernández-Rodríguez and Olaya Mediavilla.
Publicado en: Forests, Edición 2022, 13 - 285, 2022, ISSN 1999-4907
Editor: MDPI Open Access Publishing
DOI: 10.3390/f13030385

Affordable and effective optokinetic response methods to assess visual acuity and contrast sensitivity in larval to juvenile zebrafish

Autores: Alicia Gómez Sánchez, Yolanda Álvarez, Basilio Colligris, Breandán N. Kennedy
Publicado en: Open Research Europe, Edición 1, 2021, Página(s) 92, ISSN 2732-5121
Editor: European Commission Open Research Europe
DOI: 10.12688/openreseurope.13923.1

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells

Autores: Kayleigh Slater, Aisling B. Heeran, Sandra Garcia-Mulero, Helen Kalirai, Rebeca Sanz-Pamplona, Arman Rahman, Nebras Al-Attar, Mays Helmi, Fiona O’Connell, Rosa Bosch, Anna Portela, Alberto Villanueva, William M. Gallagher, Lasse D. Jensen, Josep M. Piulats, Sarah E. Coupland, Jacintha O’Sullivan, Breandán N. Kennedy
Publicado en: Cancers, Edición 12/10, 2020, Página(s) 2950, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102950

Trojan Microparticles Potential for Ophthalmic Drug Delivery

Autores: Sergio Esteban-Pérez, Irene Bravo-Osuna, Vanessa Andrés-Guerrero, Irene T. Molina-Martínez, Rocío Herrero-Vanrell
Publicado en: Current Medicinal Chemistry, Edición 27/4, 2020, Página(s) 570-582, ISSN 0929-8673
Editor: Bentham Science Publishers
DOI: 10.2174/0929867326666190905150331

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

Autores: Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan, Breandán N. Kennedy
Publicado en: Frontiers in Cell and Developmental Biology, Edición 8, 2020, ISSN 2296-634X
Editor: Frontiers Editorial
DOI: 10.3389/fcell.2020.00689

1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model

Autores: Kayleigh Slater, Rosa Bosch, Kaelin Francis Smith, Chowdhury Arif Jahangir, Sandra Garcia-Mulero, Arman Rahman, Fiona O’Connell, Josep M. Piulats, Valerie O’Neill, Noel Horgan, Sarah E. Coupland, Jacintha O’Sullivan, William M. Gallagher, Alberto Villanueva and Breandán N. Kennedy
Publicado en: Frontiers in Medicine, 2023, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fmed.2022.1036322

Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28

Autores: Ailís L. Moran,Stephen P. Carter,Joanna J. Kaylor,Zhichun Jiang,Sanne Broekman,Eugene T. Dillon,Alicia Gómez Sánchez,Sajal K. Minhas,Erwin van Wijk,Roxana A. Radu,Gabriel H. Travis,Michelle Carey,Oliver E. Blacque,Breandán N. Kennedy
Publicado en: The FASEB Journal, Edición 08926638, 2022, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101897r

Uveal Melanoma Cell Line Proliferation Is Inhibited by Ricolinostat, a Histone Deacetylase Inhibitor

Autores: Husvinee Sundaramurthi, Sandra García-Mulero, Valentina Tonelotto , Kayleigh Slater, Simone Marcon, Josep M. Piulats, Ronald WilliamWatson, Desmond J. Tobin, Lasse D. Jensen and Breandán N. Kennedy
Publicado en: Cancers, Edición 2022 Feb; 14(3): 782, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030782

Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma

Autores: K. Slater, P. S. Hoo, A. M. Buckley, J. M. Piulats, A. Villanueva, A. Portela, B. N. Kennedy
Publicado en: Cancer and Metastasis Reviews, 2018, ISSN 0167-7659
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10555-018-9751-z

Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish

Autores: Rebecca Ward, Husvinee Sundaramurthi, Valeria Di Giacomo, Breandán N. Kennedy
Publicado en: Frontiers in Cell and Developmental Biology, Edición 6, 2018, Página(s) http://hdl.handle.net/10197/9534, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/fcell.2018.00037

A review of international medical device regulations: Contact lenses and lens care solutions

Autores: Marina Zaki, Jesús Pardo, Gonzalo Carracedo
Publicado en: Contact Lens and Anterior Eye, 2018, ISSN 1367-0484
Editor: Elsevier BV
DOI: 10.1016/j.clae.2018.11.001

The potential of small molecule brain-derived neurotrophic factor: mimetics to treat inherited retinal degeneration

Autores: BreandánN Kennedy, Andrea Cerquone Perpetuini, Justine Mathoux
Publicado en: Neural Regeneration Research, Edición 14/1, 2019, Página(s) 85, ISSN 1673-5374
Editor: Neural Regeneration Research
DOI: 10.4103/1673-5374.243711

Pharmacological restoration of visual function in a zebrafish model of von-Hippel Lindau disease

Autores: Rebecca Ward, Zaheer Ali, Kayleigh Slater, Alison L. Reynolds, Lasse D. Jensen, Breandán N. Kennedy
Publicado en: Developmental Biology, 2019, ISSN 0012-1606
Editor: Academic Press
DOI: 10.1016/j.ydbio.2019.02.008

Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae

Autores: Nils Ohnesorge, Temitope Sasore, Daniel Hillary, Yolanda Alvarez, Michelle Carey, Breandán N. Kennedy
Publicado en: Frontiers in Pharmacology, Edición 10, 2019, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2019.00508

Non-photopic and photopic visual cycles differentially regulate immediate, early, and late phases of cone photoreceptor-mediated vision

Autores: Rebecca Ward, Joanna J. Kaylor, Diego F. Cobice, Dionissia A. Pepe, Eoghan M. McGarrigle, Susan E. Brockerhoff, James B. Hurley, Gabriel H. Travis, Breandán N. Kennedy
Publicado en: Journal of Biological Chemistry, Edición 295/19, 2020, Página(s) 6482-6497, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.011374

CHAPTER 9. Alternative Experimental Models of Ciliary Trafficking and Dysfunction in the Retina

Autores: Stephen P. Carter, Janina Leyk, Oliver E. Blacque, Breandán Kennedy
Publicado en: Therapies for Retinal Degeneration - Targeting Common Processes, 2018, Página(s) 144-163, ISBN 978-1-78262-949-8
Editor: Royal Society of Chemistry
DOI: 10.1039/9781788013666-00144

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