Drug Discovery and Delivery NEtwork for ONcology and Eye Therapeutics

Informazioni relative al progetto

3D NEONET

ID dell’accordo di sovvenzione: 734907

DOI

10.3030/734907

Progetto chiuso

Data della firma CE 8 Novembre 2016

Data di avvio 1 Gennaio 2017

Data di completamento 30 Giugno 2022

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 945 000,00

Contributo UE

€ 945 000,00

Coordinato da

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (6)

Gene Editing Technology for Drug Screening Report

Report reviewing exchange of knowledge in utilising gene editing technology to generate disease models for drug screening

Use of In Vivo Mammalian Models of Ocular Drug Efficacy/Safety Report

Report reviewing exchange of knowledge in relation to use of in vivo mammalian models of ocular drug efficacysafety

Development of Novel PDX Cancer Models Report

Report reviewing exchange of knowledge regarding development of novel PDX models of cancer

Exploitation of Fungal Resources in Drug Discovery and Drug Metabolism Report

Report reviewing exchange of knowledge in relation to relevance of fungi for drug discovery and drug metabolism studies

Dossier of Best Management Practices

Executive summary and dossier of reflective reports into best management practices to adopt

Zebrafish as Toxicology Screening Model Report

Reports reviewing exchange of knowledge regarding relevance of zebrafish as toxicology screening model

Websites, patent fillings, videos etc. (2)

3D-animations to enhance awareness (Cancer and Blindness)

Generation of 3D-animations to enhance awareness of the significance of cancer & blindness.

Launch of 3D-NEONET Website and Social Media

Establishment of 3D-NEONET website and social media interfaces

Other (1)

Initiation of 3D-NEONET Secondments

Initiation of 3D-NEONET Secondment Programme

Open Research Data Pilot (1)

DMP

Data Management Plan

Pubblicazioni

Peer reviewed articles (19)

Species Mixing Proportion and Aridity Influence in the Height–Diameter Relationship for Different Species Mixtures in Mediterranean Forests

Autori: Diego Rodríguez de Prado, Jose Riofrío, Jorge Aldea, James McDermott, Felipe Bravo and Celia Herrero de Aza
Pubblicato in: Forests, Numero Volume 13 (1), 119, 2022, ISSN 1999-4907
Editore: MDPI Open Access Publishing
DOI: 10.3390/f13010119

Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases

Autori: José Javier López-Cano, Sigen A., Vanessa Andrés-Guerrero, Hongyun Tai, Irene Bravo-Osuna, Irene Teresa Molina-Martínez, Wenxin Wang, Rocío Herrero-Vanrell
Pubblicato in: Pharmaceutics, Numero 13/2, 2021, Pagina/e 234, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020234

Fungal and Bacterial Communities in Tuber melanosporum Plantations from Northern Spain

Autori: Celia Herrero de Aza, Sergio Armenteros, James McDermott, Stefano Mauceri, Jaime Olaizola, María Hernández-Rodríguez and Olaya Mediavilla.
Pubblicato in: Forests, Numero 2022, 13 - 285, 2022, ISSN 1999-4907
Editore: MDPI Open Access Publishing
DOI: 10.3390/f13030385

Affordable and effective optokinetic response methods to assess visual acuity and contrast sensitivity in larval to juvenile zebrafish

Autori: Alicia Gómez Sánchez, Yolanda Álvarez, Basilio Colligris, Breandán N. Kennedy
Pubblicato in: Open Research Europe, Numero 1, 2021, Pagina/e 92, ISSN 2732-5121
Editore: European Commission Open Research Europe
DOI: 10.12688/openreseurope.13923.1

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells

Autori: Kayleigh Slater, Aisling B. Heeran, Sandra Garcia-Mulero, Helen Kalirai, Rebeca Sanz-Pamplona, Arman Rahman, Nebras Al-Attar, Mays Helmi, Fiona O’Connell, Rosa Bosch, Anna Portela, Alberto Villanueva, William M. Gallagher, Lasse D. Jensen, Josep M. Piulats, Sarah E. Coupland, Jacintha O’Sullivan, Breandán N. Kennedy
Pubblicato in: Cancers, Numero 12/10, 2020, Pagina/e 2950, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102950

Trojan Microparticles Potential for Ophthalmic Drug Delivery

Autori: Sergio Esteban-Pérez, Irene Bravo-Osuna, Vanessa Andrés-Guerrero, Irene T. Molina-Martínez, Rocío Herrero-Vanrell
Pubblicato in: Current Medicinal Chemistry, Numero 27/4, 2020, Pagina/e 570-582, ISSN 0929-8673
Editore: Bentham Science Publishers
DOI: 10.2174/0929867326666190905150331

Assessment of ferroptosis as a promising candidate for metastatic uveal melanoma treatment and prognostication

Autori: Ellie Swords, Breandán N. Kennedy, Valentina Tonelotto
Pubblicato in: Frontiers in Pharmacology, Numero 15, 2024, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1466896

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

Autori: Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan, Breandán N. Kennedy
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 8, 2020, ISSN 2296-634X
Editore: Frontiers Editorial
DOI: 10.3389/fcell.2020.00689

1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model

Autori: Kayleigh Slater, Rosa Bosch, Kaelin Francis Smith, Chowdhury Arif Jahangir, Sandra Garcia-Mulero, Arman Rahman, Fiona O’Connell, Josep M. Piulats, Valerie O’Neill, Noel Horgan, Sarah E. Coupland, Jacintha O’Sullivan, William M. Gallagher, Alberto Villanueva and Breandán N. Kennedy
Pubblicato in: Frontiers in Medicine, 2023, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fmed.2022.1036322

Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28

Autori: Ailís L. Moran,Stephen P. Carter,Joanna J. Kaylor,Zhichun Jiang,Sanne Broekman,Eugene T. Dillon,Alicia Gómez Sánchez,Sajal K. Minhas,Erwin van Wijk,Roxana A. Radu,Gabriel H. Travis,Michelle Carey,Oliver E. Blacque,Breandán N. Kennedy
Pubblicato in: The FASEB Journal, Numero Volume 36, Numero5, 2022, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101897r

Uveal Melanoma Cell Line Proliferation Is Inhibited by Ricolinostat, a Histone Deacetylase Inhibitor

Autori: Husvinee Sundaramurthi, Sandra García-Mulero, Valentina Tonelotto , Kayleigh Slater, Simone Marcon, Josep M. Piulats, Ronald WilliamWatson, Desmond J. Tobin, Lasse D. Jensen and Breandán N. Kennedy
Pubblicato in: Cancers, Numero 2022 Feb; 14(3): 782, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030782

Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma

Autori: K. Slater, P. S. Hoo, A. M. Buckley, J. M. Piulats, A. Villanueva, A. Portela, B. N. Kennedy
Pubblicato in: Cancer and Metastasis Reviews, 2018, ISSN 0167-7659
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10555-018-9751-z

Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish

Autori: Rebecca Ward, Husvinee Sundaramurthi, Valeria Di Giacomo, Breandán N. Kennedy
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 6, 2018, Pagina/e http://hdl.handle.net/10197/9534, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2018.00037

A review of international medical device regulations: Contact lenses and lens care solutions

Autori: Marina Zaki, Jesús Pardo, Gonzalo Carracedo
Pubblicato in: Contact Lens and Anterior Eye, 2018, ISSN 1367-0484
Editore: Elsevier BV
DOI: 10.1016/j.clae.2018.11.001

The potential of small molecule brain-derived neurotrophic factor: mimetics to treat inherited retinal degeneration

Autori: BreandánN Kennedy, Andrea Cerquone Perpetuini, Justine Mathoux
Pubblicato in: Neural Regeneration Research, Numero 14/1, 2019, Pagina/e 85, ISSN 1673-5374
Editore: Neural Regeneration Research
DOI: 10.4103/1673-5374.243711

Pharmacological restoration of visual function in a zebrafish model of von-Hippel Lindau disease

Autori: Rebecca Ward, Zaheer Ali, Kayleigh Slater, Alison L. Reynolds, Lasse D. Jensen, Breandán N. Kennedy
Pubblicato in: Developmental Biology, 2019, ISSN 0012-1606
Editore: Academic Press
DOI: 10.1016/j.ydbio.2019.02.008

Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae

Autori: Nils Ohnesorge, Temitope Sasore, Daniel Hillary, Yolanda Alvarez, Michelle Carey, Breandán N. Kennedy
Pubblicato in: Frontiers in Pharmacology, Numero 10, 2019, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2019.00508

Non-photopic and photopic visual cycles differentially regulate immediate, early, and late phases of cone photoreceptor-mediated vision

Autori: Rebecca Ward, Joanna J. Kaylor, Diego F. Cobice, Dionissia A. Pepe, Eoghan M. McGarrigle, Susan E. Brockerhoff, James B. Hurley, Gabriel H. Travis, Breandán N. Kennedy
Pubblicato in: Journal of Biological Chemistry, Numero 295/19, 2020, Pagina/e 6482-6497, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.011374

1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature

Autori: Valentina Tonelotto, Marcel Costa-Garcia, Eve O’Reilly, Kaelin Francis Smith, Kayleigh Slater, Eugene T. Dillon, Marzia Pendino, Catherine Higgins, Paola Sist, Rosa Bosch, Sabina Passamonti, Josep M. Piulats, Alberto Villanueva, Federica Tramer, Luca Vanella, Michelle Carey, Breandán N. Kennedy
Pubblicato in: Cell Death Discovery, Numero 10, 2024, ISSN 2058-7716
Editore: Nature Publishing Group
DOI: 10.1038/s41420-023-01773-8

Book chapters (1)

CHAPTER 9. Alternative Experimental Models of Ciliary Trafficking and Dysfunction in the Retina

Autori: Stephen P. Carter, Janina Leyk, Oliver E. Blacque, Breandán Kennedy
Pubblicato in: Therapies for Retinal Degeneration - Targeting Common Processes, 2018, Pagina/e 144-163, ISBN 978-1-78262-949-8
Editore: Royal Society of Chemistry
DOI: 10.1039/9781788013666-00144