Drug Discovery and Delivery NEtwork for ONcology and Eye Therapeutics

Livrables

Gene Editing Technology for Drug Screening Report

Report reviewing exchange of knowledge in utilising gene editing technology to generate disease models for drug screening

Use of In Vivo Mammalian Models of Ocular Drug Efficacy/Safety Report

Report reviewing exchange of knowledge in relation to use of in vivo mammalian models of ocular drug efficacysafety

Development of Novel PDX Cancer Models Report

Report reviewing exchange of knowledge regarding development of novel PDX models of cancer

Exploitation of Fungal Resources in Drug Discovery and Drug Metabolism Report

Report reviewing exchange of knowledge in relation to relevance of fungi for drug discovery and drug metabolism studies

Dossier of Best Management Practices

Executive summary and dossier of reflective reports into best management practices to adopt

Zebrafish as Toxicology Screening Model Report

Reports reviewing exchange of knowledge regarding relevance of zebrafish as toxicology screening model

3D-animations to enhance awareness (Cancer and Blindness)

Generation of 3D-animations to enhance awareness of the significance of cancer & blindness.

Launch of 3D-NEONET Website and Social Media

Establishment of 3D-NEONET website and social media interfaces

Initiation of 3D-NEONET Secondments

Initiation of 3D-NEONET Secondment Programme

DMP

Data Management Plan

Publications

Species Mixing Proportion and Aridity Influence in the Height–Diameter Relationship for Different Species Mixtures in Mediterranean Forests

Auteurs: Diego Rodríguez de Prado, Jose Riofrío, Jorge Aldea, James McDermott, Felipe Bravo and Celia Herrero de Aza
Publié dans: Forests, Numéro 19994907, 2022, ISSN 1999-4907
Éditeur: MDPI Open Access Publishing
DOI: 10.3390/f13010119

Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases

Auteurs: José Javier López-Cano, Sigen A., Vanessa Andrés-Guerrero, Hongyun Tai, Irene Bravo-Osuna, Irene Teresa Molina-Martínez, Wenxin Wang, Rocío Herrero-Vanrell
Publié dans: Pharmaceutics, Numéro 13/2, 2021, Page(s) 234, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13020234

Fungal and Bacterial Communities in Tuber melanosporum Plantations from Northern Spain

Auteurs: Celia Herrero de Aza, Sergio Armenteros, James McDermott, Stefano Mauceri, Jaime Olaizola, María Hernández-Rodríguez and Olaya Mediavilla.
Publié dans: Forests, Numéro 2022, 13 - 285, 2022, ISSN 1999-4907
Éditeur: MDPI Open Access Publishing
DOI: 10.3390/f13030385

Affordable and effective optokinetic response methods to assess visual acuity and contrast sensitivity in larval to juvenile zebrafish

Auteurs: Alicia Gómez Sánchez, Yolanda Álvarez, Basilio Colligris, Breandán N. Kennedy
Publié dans: Open Research Europe, Numéro 1, 2021, Page(s) 92, ISSN 2732-5121
Éditeur: European Commission Open Research Europe
DOI: 10.12688/openreseurope.13923.1

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells

Auteurs: Kayleigh Slater, Aisling B. Heeran, Sandra Garcia-Mulero, Helen Kalirai, Rebeca Sanz-Pamplona, Arman Rahman, Nebras Al-Attar, Mays Helmi, Fiona O’Connell, Rosa Bosch, Anna Portela, Alberto Villanueva, William M. Gallagher, Lasse D. Jensen, Josep M. Piulats, Sarah E. Coupland, Jacintha O’Sullivan, Breandán N. Kennedy
Publié dans: Cancers, Numéro 12/10, 2020, Page(s) 2950, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12102950

Trojan Microparticles Potential for Ophthalmic Drug Delivery

Auteurs: Sergio Esteban-Pérez, Irene Bravo-Osuna, Vanessa Andrés-Guerrero, Irene T. Molina-Martínez, Rocío Herrero-Vanrell
Publié dans: Current Medicinal Chemistry, Numéro 27/4, 2020, Page(s) 570-582, ISSN 0929-8673
Éditeur: Bentham Science Publishers
DOI: 10.2174/0929867326666190905150331

Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

Auteurs: Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan, Breandán N. Kennedy
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 8, 2020, ISSN 2296-634X
Éditeur: Frontiers Editorial
DOI: 10.3389/fcell.2020.00689

1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model

Auteurs: Kayleigh Slater, Rosa Bosch, Kaelin Francis Smith, Chowdhury Arif Jahangir, Sandra Garcia-Mulero, Arman Rahman, Fiona O’Connell, Josep M. Piulats, Valerie O’Neill, Noel Horgan, Sarah E. Coupland, Jacintha O’Sullivan, William M. Gallagher, Alberto Villanueva and Breandán N. Kennedy
Publié dans: Frontiers in Medicine, 2023, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fmed.2022.1036322

Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28

Auteurs: Ailís L. Moran,Stephen P. Carter,Joanna J. Kaylor,Zhichun Jiang,Sanne Broekman,Eugene T. Dillon,Alicia Gómez Sánchez,Sajal K. Minhas,Erwin van Wijk,Roxana A. Radu,Gabriel H. Travis,Michelle Carey,Oliver E. Blacque,Breandán N. Kennedy
Publié dans: The FASEB Journal, Numéro 08926638, 2022, ISSN 0892-6638
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101897r

Uveal Melanoma Cell Line Proliferation Is Inhibited by Ricolinostat, a Histone Deacetylase Inhibitor

Auteurs: Husvinee Sundaramurthi, Sandra García-Mulero, Valentina Tonelotto , Kayleigh Slater, Simone Marcon, Josep M. Piulats, Ronald WilliamWatson, Desmond J. Tobin, Lasse D. Jensen and Breandán N. Kennedy
Publié dans: Cancers, Numéro 2022 Feb; 14(3): 782, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030782

Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma

Auteurs: K. Slater, P. S. Hoo, A. M. Buckley, J. M. Piulats, A. Villanueva, A. Portela, B. N. Kennedy
Publié dans: Cancer and Metastasis Reviews, 2018, ISSN 0167-7659
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10555-018-9751-z

Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish

Auteurs: Rebecca Ward, Husvinee Sundaramurthi, Valeria Di Giacomo, Breandán N. Kennedy
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 6, 2018, Page(s) http://hdl.handle.net/10197/9534, ISSN 2296-634X
Éditeur: Frontiers
DOI: 10.3389/fcell.2018.00037

A review of international medical device regulations: Contact lenses and lens care solutions

Auteurs: Marina Zaki, Jesús Pardo, Gonzalo Carracedo
Publié dans: Contact Lens and Anterior Eye, 2018, ISSN 1367-0484
Éditeur: Elsevier BV
DOI: 10.1016/j.clae.2018.11.001

The potential of small molecule brain-derived neurotrophic factor: mimetics to treat inherited retinal degeneration

Auteurs: BreandánN Kennedy, Andrea Cerquone Perpetuini, Justine Mathoux
Publié dans: Neural Regeneration Research, Numéro 14/1, 2019, Page(s) 85, ISSN 1673-5374
Éditeur: Neural Regeneration Research
DOI: 10.4103/1673-5374.243711

Pharmacological restoration of visual function in a zebrafish model of von-Hippel Lindau disease

Auteurs: Rebecca Ward, Zaheer Ali, Kayleigh Slater, Alison L. Reynolds, Lasse D. Jensen, Breandán N. Kennedy
Publié dans: Developmental Biology, 2019, ISSN 0012-1606
Éditeur: Academic Press
DOI: 10.1016/j.ydbio.2019.02.008

Orthogonal Drug Pooling Enhances Phenotype-Based Discovery of Ocular Antiangiogenic Drugs in Zebrafish Larvae

Auteurs: Nils Ohnesorge, Temitope Sasore, Daniel Hillary, Yolanda Alvarez, Michelle Carey, Breandán N. Kennedy
Publié dans: Frontiers in Pharmacology, Numéro 10, 2019, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2019.00508

Non-photopic and photopic visual cycles differentially regulate immediate, early, and late phases of cone photoreceptor-mediated vision

Auteurs: Rebecca Ward, Joanna J. Kaylor, Diego F. Cobice, Dionissia A. Pepe, Eoghan M. McGarrigle, Susan E. Brockerhoff, James B. Hurley, Gabriel H. Travis, Breandán N. Kennedy
Publié dans: Journal of Biological Chemistry, Numéro 295/19, 2020, Page(s) 6482-6497, ISSN 0021-9258
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.011374

CHAPTER 9. Alternative Experimental Models of Ciliary Trafficking and Dysfunction in the Retina

Auteurs: Stephen P. Carter, Janina Leyk, Oliver E. Blacque, Breandán Kennedy
Publié dans: Therapies for Retinal Degeneration - Targeting Common Processes, 2018, Page(s) 144-163, ISBN 978-1-78262-949-8
Éditeur: Royal Society of Chemistry
DOI: 10.1039/9781788013666-00144

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