Noise and robustness in the evolution of novel protein phenotypes

Project Information

NoiseRobustEvo

Grant agreement ID: 739874

DOI

10.3030/739874

Project closed

EC signature date 24 May 2017

Start date 1 October 2017

End date 31 March 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 383 444,00

EU contribution

€ 2 383 444,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (21)

Signaling pathways have an inherent need for noise to acquire information.

Author(s): Azpeitia, Eugenio; Balanzario, Eugenio P; Wagner, Andreas (
Published in: BMC Bioinformatics, 21:462, 2020, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-020-03778-x

Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments.

Author(s): Schmutzer, Michael; Wagner, Andreas
Published in: PLoS Computational Biology, 16(10):e1007727, 2020, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1101/2020.02.13.947275

The length scale of multivalent interactions is evolutionarily conserved in fungal and vertebrate phase-separating proteins.

Author(s): Pouria Dasmeh; Pouria Dasmeh; Pouria Dasmeh; Roman Doronin; Roman Doronin; Andreas Wagner
Published in: Genetics, 220(1):iyab184, Issue 35, 2022, ISSN 0016-6731
Publisher: Genetics Society of America
DOI: 10.1093/genetics/iyab184

Natural Selection on the Phase-Separation Properties of FUS during 160 My of Mammalian Evolution

Author(s): Dasmeh, Pouria; Wagner, Andreas
Published in: Molecular Biology and Evolution, Issue Volume 38, Issue 3, 2021, Page(s) 940–951, ISSN 0737-4038
Publisher: Oxford University Press
DOI: 10.1093/molbev/msaa258

Mistranslation Reduces Mutation Load in Evolving Proteins through Negative Epistasis with DNA Mutations.

Author(s): Jia Zheng; Jia Zheng; Ning Guo; Andreas Wagner; Andreas Wagner; Andreas Wagner
Published in: Molecular Biology and Evolution, Issue 46, 2021, ISSN 0737-4038
Publisher: Oxford University Press
DOI: 10.1093/molbev/msab206

Selection enhances protein evolvability by increasing mutational robustness and foldability.

Author(s): Jia Zheng; Jia Zheng; Ning Guo; Andreas Wagner; Andreas Wagner; Andreas Wagner
Published in: Science, 370(6521):eabb5962, Issue 40, 2020, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abb5962

Yeast Proteins may Reversibly Aggregate like Amphiphilic Molecules.

Author(s): Pouria Dasmeh; Pouria Dasmeh; Pouria Dasmeh; Andreas Wagner
Published in: Journal of Molecular Biology, 434(2):167352, Issue 38, 2022, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2021.167352

Adaptive gene misregulation.

Author(s): Andreas Wagner
Published in: Genetics, 217(3):iyaa044, Issue 37, 2021, ISSN 0016-6731
Publisher: Genetics Society of America
DOI: 10.1093/genetics/iyaa044

Mistranslation can promote the exploration of alternative evolutionary trajectories in enzyme evolution

Author(s): Zheng, Jia; Bratulic, Sinisa; Licher, Heidi E.L.; Wagner, Andreas
Published in: Journal of Evolutionary Biology, Issue Volume 34, issue 8, 2021, Page(s) 1302-1315, ISSN 1010-061X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jeb.13892

RNA-mediated gene regulation is less evolvable than transcriptional regulation

Author(s): Payne, Joshua L; Khalid, Fahad; Wagner, Andreas
Published in: PNAS, Issue 3, 2018, ISSN 1091-6490
Publisher: Highwire Press
DOI: 10.5167/uzh-167214

The architecture of an empirical genotype-phenotype map

Author(s): Aguilar-Rodríguez, José; Peel, Leto; Stella, Massimo; Wagner, Andreas; Payne, Joshua L.
Published in: Evolution, 72 (6), Issue 11, 2018, ISSN 1558-5646
Publisher: Wiley
DOI: 10.3929/ethz-b-000274406

High mutation rates limit evolutionary adaptation in Escherichia coli

Author(s): Kathleen Sprouffske, José Aguilar-Rodríguez, Paul Sniegowski, Andreas Wagner
Published in: PLOS Genetics, Issue 14/4, 2018, Page(s) e1007324, ISSN 1553-7404
Publisher: PLOS
DOI: 10.1371/journal.pgen.1007324

Cryptic genetic variation accelerates evolution by opening access to diverse adaptive peaks

Author(s): Jia Zheng, Joshua L. Payne, Andreas Wagner
Published in: Science, Issue 365/6451, 2019, Page(s) 347-353, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax1837

The causes of evolvability and their evolution

Author(s): Joshua L. Payne, Andreas Wagner
Published in: Nature Reviews Genetics, Issue 20/1, 2019, Page(s) 24-38, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/s41576-018-0069-z

Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli

Author(s): Aguilar-Rodríguez, José; Fares, Mario A; Wagner, Andreas
Published in: Aguilar-Rodríguez, José; Fares, Mario A; Wagner, Andreas (2019). Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli. FEMS Microbiology Letters, 366(10):fnz121., Issue 1, 2019, ISSN 0378-1097
Publisher: Blackwell
DOI: 10.5167/uzh-182142

GroEL/S Overexpression Helps to Purge Deleterious Mutations and Reduce Genetic Diversity during Adaptive Protein Evolution

Author(s): Iyengar, Bharat Ravi; Wagner, Andreas
Published in: Moelecular Biology and Evolution, Issue Volume 39, 2022, Page(s) Issue 6, ISSN 1537-1719
Publisher: Oxford University Press
DOI: 10.1093/molbev/msac047

Short Residence Times of DNA-Bound Transcription Factors Can Reduce Gene Expression Noise and Increase the Transmission of Information in a Gene Regulation System

Author(s): Eugenio Azpeitia, Andreas Wagner
Published in: Frontiers in Molecular Biosciences, Issue 7, 2020, ISSN 2296-889X
Publisher: frontiers in molecular biosciences
DOI: 10.3389/fmolb.2020.00067

Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability

Author(s): Karve, Shraddha; Dasmeh, Pouria; Zheng, Jia; Wagner, Andreas
Published in: Nature Ecology & Evolution, Issue 6, 2022, Page(s) 1155–1164, ISSN 2397-334X
Publisher: Nature Publishing Group
DOI: 10.1038/s41559-022-01797-w

Adaptive evolvability through direct selection instead of indirect, second-order selection.

Author(s): Wagner, Andreas
Published in: Journal of Experimental Zoology. Part B: Molecular and Developmental Evolution:Epub ahead of print., Issue 42, 2021, ISSN 1552-5007
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/jez.b.23071

Information theory can help quantify the potential of new phenotypes to originate as exaptations.

Author(s): Wagner, Andreas
Published in: Frontiers in Ecology and Evolution, 8:564071., 2020, ISSN 2296-701X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fevo.2020.564071

Bacterial Hsp90 predominantly buffers but does not potentiate the phenotypic effects of deleterious mutations during fluorescent protein evolution.

Author(s): Iyengar, Bharat Ravi; Wagner, Andreas
Published in: Genetics, Issue Vol. 222, Issue 4, December 2022, 2022, Page(s) iyac154, ISSN 1943-2631
Publisher: Oxford University Press
DOI: 10.1093/genetics/iyac154