Noise and robustness in the evolution of novel protein phenotypes

Publicaciones

Signaling pathways have an inherent need for noise to acquire information.

Autores: Azpeitia, Eugenio; Balanzario, Eugenio P; Wagner, Andreas (
Publicado en: BMC Bioinformatics, 21:462, 2020, ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/s12859-020-03778-x

Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments.

Autores: Schmutzer, Michael; Wagner, Andreas
Publicado en: PLoS Computational Biology, 16(10):e1007727, 2020, ISSN 1553-734X
Editor: Public Library of Science
DOI: 10.1101/2020.02.13.947275

The length scale of multivalent interactions is evolutionarily conserved in fungal and vertebrate phase-separating proteins.

Autores: Pouria Dasmeh; Pouria Dasmeh; Pouria Dasmeh; Roman Doronin; Roman Doronin; Andreas Wagner
Publicado en: Genetics, 220(1):iyab184, Edición 35, 2022, ISSN 0016-6731
Editor: Genetics Society of America
DOI: 10.1093/genetics/iyab184

Natural Selection on the Phase-Separation Properties of FUS during 160 My of Mammalian Evolution

Autores: Dasmeh, Pouria; Wagner, Andreas
Publicado en: Molecular Biology and Evolution, Edición Volume 38, Edición 3, 2021, Página(s) 940–951, ISSN 0737-4038
Editor: Oxford University Press
DOI: 10.1093/molbev/msaa258

Mistranslation Reduces Mutation Load in Evolving Proteins through Negative Epistasis with DNA Mutations.

Autores: Jia Zheng; Jia Zheng; Ning Guo; Andreas Wagner; Andreas Wagner; Andreas Wagner
Publicado en: Molecular Biology and Evolution, Edición 46, 2021, ISSN 0737-4038
Editor: Oxford University Press
DOI: 10.1093/molbev/msab206

Selection enhances protein evolvability by increasing mutational robustness and foldability.

Autores: Jia Zheng; Jia Zheng; Ning Guo; Andreas Wagner; Andreas Wagner; Andreas Wagner
Publicado en: Science, 370(6521):eabb5962, Edición 40, 2020, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.abb5962

Yeast Proteins may Reversibly Aggregate like Amphiphilic Molecules.

Autores: Pouria Dasmeh; Pouria Dasmeh; Pouria Dasmeh; Andreas Wagner
Publicado en: Journal of Molecular Biology, 434(2):167352, Edición 38, 2022, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/j.jmb.2021.167352

Adaptive gene misregulation.

Autores: Andreas Wagner
Publicado en: Genetics, 217(3):iyaa044, Edición 37, 2021, ISSN 0016-6731
Editor: Genetics Society of America
DOI: 10.1093/genetics/iyaa044

Mistranslation can promote the exploration of alternative evolutionary trajectories in enzyme evolution

Autores: Zheng, Jia; Bratulic, Sinisa; Licher, Heidi E.L.; Wagner, Andreas
Publicado en: Journal of Evolutionary Biology, Edición Volume 34, issue 8, 2021, Página(s) 1302-1315, ISSN 1010-061X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jeb.13892

RNA-mediated gene regulation is less evolvable than transcriptional regulation

Autores: Payne, Joshua L; Khalid, Fahad; Wagner, Andreas
Publicado en: PNAS, Edición 3, 2018, ISSN 1091-6490
Editor: Highwire Press
DOI: 10.5167/uzh-167214

The architecture of an empirical genotype-phenotype map

Autores: Aguilar-Rodríguez, José; Peel, Leto; Stella, Massimo; Wagner, Andreas; Payne, Joshua L.
Publicado en: Evolution, 72 (6), Edición 11, 2018, ISSN 1558-5646
Editor: Wiley
DOI: 10.3929/ethz-b-000274406

High mutation rates limit evolutionary adaptation in Escherichia coli

Autores: Kathleen Sprouffske, José Aguilar-Rodríguez, Paul Sniegowski, Andreas Wagner
Publicado en: PLOS Genetics, Edición 14/4, 2018, Página(s) e1007324, ISSN 1553-7404
Editor: PLOS
DOI: 10.1371/journal.pgen.1007324

Cryptic genetic variation accelerates evolution by opening access to diverse adaptive peaks

Autores: Jia Zheng, Joshua L. Payne, Andreas Wagner
Publicado en: Science, Edición 365/6451, 2019, Página(s) 347-353, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aax1837

The causes of evolvability and their evolution

Autores: Joshua L. Payne, Andreas Wagner
Publicado en: Nature Reviews Genetics, Edición 20/1, 2019, Página(s) 24-38, ISSN 1471-0056
Editor: Nature Publishing Group
DOI: 10.1038/s41576-018-0069-z

Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli

Autores: Aguilar-Rodríguez, José; Fares, Mario A; Wagner, Andreas
Publicado en: Aguilar-Rodríguez, José; Fares, Mario A; Wagner, Andreas (2019). Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli. FEMS Microbiology Letters, 366(10):fnz121., Edición 1, 2019, ISSN 0378-1097
Editor: Blackwell
DOI: 10.5167/uzh-182142

GroEL/S Overexpression Helps to Purge Deleterious Mutations and Reduce Genetic Diversity during Adaptive Protein Evolution

Autores: Iyengar, Bharat Ravi; Wagner, Andreas
Publicado en: Moelecular Biology and Evolution, Edición Volume 39, 2022, Página(s) Edición 6, ISSN 1537-1719
Editor: Oxford University Press
DOI: 10.1093/molbev/msac047

Short Residence Times of DNA-Bound Transcription Factors Can Reduce Gene Expression Noise and Increase the Transmission of Information in a Gene Regulation System

Autores: Eugenio Azpeitia, Andreas Wagner
Publicado en: Frontiers in Molecular Biosciences, Edición 7, 2020, ISSN 2296-889X
Editor: frontiers in molecular biosciences
DOI: 10.3389/fmolb.2020.00067

Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability

Autores: Karve, Shraddha; Dasmeh, Pouria; Zheng, Jia; Wagner, Andreas
Publicado en: Nature Ecology & Evolution, Edición 6, 2022, Página(s) 1155–1164, ISSN 2397-334X
Editor: Nature Publishing Group
DOI: 10.1038/s41559-022-01797-w

Adaptive evolvability through direct selection instead of indirect, second-order selection.

Autores: Wagner, Andreas
Publicado en: Journal of Experimental Zoology. Part B: Molecular and Developmental Evolution:Epub ahead of print., Edición 42, 2021, ISSN 1552-5007
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/jez.b.23071

Information theory can help quantify the potential of new phenotypes to originate as exaptations.

Autores: Wagner, Andreas
Publicado en: Frontiers in Ecology and Evolution, 8:564071., 2020, ISSN 2296-701X
Editor: Frontiers Research Foundation
DOI: 10.3389/fevo.2020.564071

Bacterial Hsp90 predominantly buffers but does not potentiate the phenotypic effects of deleterious mutations during fluorescent protein evolution.

Autores: Iyengar, Bharat Ravi; Wagner, Andreas
Publicado en: Genetics, Edición Vol. 222, Edición 4, December 2022, 2022, Página(s) iyac154, ISSN 1943-2631
Editor: Oxford University Press
DOI: 10.1093/genetics/iyac154

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