Noise and robustness in the evolution of novel protein phenotypes

Pubblicazioni

Signaling pathways have an inherent need for noise to acquire information.

Autori: Azpeitia, Eugenio; Balanzario, Eugenio P; Wagner, Andreas (
Pubblicato in: BMC Bioinformatics, 21:462, 2020, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-020-03778-x

Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments.

Autori: Schmutzer, Michael; Wagner, Andreas
Pubblicato in: PLoS Computational Biology, 16(10):e1007727, 2020, ISSN 1553-734X
Editore: Public Library of Science
DOI: 10.1101/2020.02.13.947275

The length scale of multivalent interactions is evolutionarily conserved in fungal and vertebrate phase-separating proteins.

Autori: Pouria Dasmeh; Pouria Dasmeh; Pouria Dasmeh; Roman Doronin; Roman Doronin; Andreas Wagner
Pubblicato in: Genetics, 220(1):iyab184, Numero 35, 2022, ISSN 0016-6731
Editore: Genetics Society of America
DOI: 10.1093/genetics/iyab184

Natural Selection on the Phase-Separation Properties of FUS during 160 My of Mammalian Evolution

Autori: Dasmeh, Pouria; Wagner, Andreas
Pubblicato in: Molecular Biology and Evolution, Numero Volume 38, Numero 3, 2021, Pagina/e 940–951, ISSN 0737-4038
Editore: Oxford University Press
DOI: 10.1093/molbev/msaa258

Mistranslation Reduces Mutation Load in Evolving Proteins through Negative Epistasis with DNA Mutations.

Autori: Jia Zheng; Jia Zheng; Ning Guo; Andreas Wagner; Andreas Wagner; Andreas Wagner
Pubblicato in: Molecular Biology and Evolution, Numero 46, 2021, ISSN 0737-4038
Editore: Oxford University Press
DOI: 10.1093/molbev/msab206

Selection enhances protein evolvability by increasing mutational robustness and foldability.

Autori: Jia Zheng; Jia Zheng; Ning Guo; Andreas Wagner; Andreas Wagner; Andreas Wagner
Pubblicato in: Science, 370(6521):eabb5962, Numero 40, 2020, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abb5962

Yeast Proteins may Reversibly Aggregate like Amphiphilic Molecules.

Autori: Pouria Dasmeh; Pouria Dasmeh; Pouria Dasmeh; Andreas Wagner
Pubblicato in: Journal of Molecular Biology, 434(2):167352, Numero 38, 2022, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2021.167352

Adaptive gene misregulation.

Autori: Andreas Wagner
Pubblicato in: Genetics, 217(3):iyaa044, Numero 37, 2021, ISSN 0016-6731
Editore: Genetics Society of America
DOI: 10.1093/genetics/iyaa044

Mistranslation can promote the exploration of alternative evolutionary trajectories in enzyme evolution

Autori: Zheng, Jia; Bratulic, Sinisa; Licher, Heidi E.L.; Wagner, Andreas
Pubblicato in: Journal of Evolutionary Biology, Numero Volume 34, issue 8, 2021, Pagina/e 1302-1315, ISSN 1010-061X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jeb.13892

RNA-mediated gene regulation is less evolvable than transcriptional regulation

Autori: Payne, Joshua L; Khalid, Fahad; Wagner, Andreas
Pubblicato in: PNAS, Numero 3, 2018, ISSN 1091-6490
Editore: Highwire Press
DOI: 10.5167/uzh-167214

The architecture of an empirical genotype-phenotype map

Autori: Aguilar-Rodríguez, José; Peel, Leto; Stella, Massimo; Wagner, Andreas; Payne, Joshua L.
Pubblicato in: Evolution, 72 (6), Numero 11, 2018, ISSN 1558-5646
Editore: Wiley
DOI: 10.3929/ethz-b-000274406

High mutation rates limit evolutionary adaptation in Escherichia coli

Autori: Kathleen Sprouffske, José Aguilar-Rodríguez, Paul Sniegowski, Andreas Wagner
Pubblicato in: PLOS Genetics, Numero 14/4, 2018, Pagina/e e1007324, ISSN 1553-7404
Editore: PLOS
DOI: 10.1371/journal.pgen.1007324

Cryptic genetic variation accelerates evolution by opening access to diverse adaptive peaks

Autori: Jia Zheng, Joshua L. Payne, Andreas Wagner
Pubblicato in: Science, Numero 365/6451, 2019, Pagina/e 347-353, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aax1837

The causes of evolvability and their evolution

Autori: Joshua L. Payne, Andreas Wagner
Pubblicato in: Nature Reviews Genetics, Numero 20/1, 2019, Pagina/e 24-38, ISSN 1471-0056
Editore: Nature Publishing Group
DOI: 10.1038/s41576-018-0069-z

Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli

Autori: Aguilar-Rodríguez, José; Fares, Mario A; Wagner, Andreas
Pubblicato in: Aguilar-Rodríguez, José; Fares, Mario A; Wagner, Andreas (2019). Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli. FEMS Microbiology Letters, 366(10):fnz121., Numero 1, 2019, ISSN 0378-1097
Editore: Blackwell
DOI: 10.5167/uzh-182142

GroEL/S Overexpression Helps to Purge Deleterious Mutations and Reduce Genetic Diversity during Adaptive Protein Evolution

Autori: Iyengar, Bharat Ravi; Wagner, Andreas
Pubblicato in: Moelecular Biology and Evolution, Numero Volume 39, 2022, Pagina/e Numero 6, ISSN 1537-1719
Editore: Oxford University Press
DOI: 10.1093/molbev/msac047

Short Residence Times of DNA-Bound Transcription Factors Can Reduce Gene Expression Noise and Increase the Transmission of Information in a Gene Regulation System

Autori: Eugenio Azpeitia, Andreas Wagner
Pubblicato in: Frontiers in Molecular Biosciences, Numero 7, 2020, ISSN 2296-889X
Editore: frontiers in molecular biosciences
DOI: 10.3389/fmolb.2020.00067

Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability

Autori: Karve, Shraddha; Dasmeh, Pouria; Zheng, Jia; Wagner, Andreas
Pubblicato in: Nature Ecology & Evolution, Numero 6, 2022, Pagina/e 1155–1164, ISSN 2397-334X
Editore: Nature Publishing Group
DOI: 10.1038/s41559-022-01797-w

Adaptive evolvability through direct selection instead of indirect, second-order selection.

Autori: Wagner, Andreas
Pubblicato in: Journal of Experimental Zoology. Part B: Molecular and Developmental Evolution:Epub ahead of print., Numero 42, 2021, ISSN 1552-5007
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/jez.b.23071

Information theory can help quantify the potential of new phenotypes to originate as exaptations.

Autori: Wagner, Andreas
Pubblicato in: Frontiers in Ecology and Evolution, 8:564071., 2020, ISSN 2296-701X
Editore: Frontiers Research Foundation
DOI: 10.3389/fevo.2020.564071

Bacterial Hsp90 predominantly buffers but does not potentiate the phenotypic effects of deleterious mutations during fluorescent protein evolution.

Autori: Iyengar, Bharat Ravi; Wagner, Andreas
Pubblicato in: Genetics, Numero Vol. 222, Numero 4, December 2022, 2022, Pagina/e iyac154, ISSN 1943-2631
Editore: Oxford University Press
DOI: 10.1093/genetics/iyac154

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