An Integrated Heart Model for the simulation of the cardiac function

Informations projet

iHEART

N° de convention de subvention: 740132

DOI

10.3030/740132

Projet clôturé

Date de signature de la CE 17 Mai 2017

Date de début 1 Decembre 2017

Date de fin 31 Mai 2023

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 2 351 544,00

Contribution de l’UE

€ 2 351 544,00

Coordonné par

POLITECNICO DI MILANO
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

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Publications

Peer reviewed articles (48)

A Multiscale Poromechanics Model Integrating Myocardial Perfusion and the Epicardial Coronary Vessels

Auteurs: Nicolás Alejandro Barnafi Wittwer; Simone Di Gregorio; Luca Dede'; Paolo Zunino; Christian Vergara; Alfio Quarteroni
Publié dans: SIAM Journal on Applied Mathematics, Numéro Vol. 82, Iss. 4 (2022), 2022, ISSN 0036-1399
Éditeur: Society for Industrial and Applied Mathematics
DOI: 10.1137/21m1424482

Iterative splitting schemes for a soft material poromechanics model

Auteurs: Jakub Wiktor Both; Nicolas A. Barnafi; Nicolas A. Barnafi; Florin Adrian Radu; Paolo Zunino; Alfio Quarteroni
Publié dans: Computer Methods in Applied Mechanics and Engineering, Numéro 1, 2022, ISSN 0045-7825
Éditeur: Elsevier BV
DOI: 10.1016/j.cma.2021.114183

An oscillation-free fully staggered algorithm for velocity-dependent active models of cardiac mechanics

Auteurs: F. Regazzoni, A. Quarteroni
Publié dans: Computer Methods in Applied Mechanics and Engineering, Numéro Volume 373, 1 January 2021, 113506, 2021, ISSN 0045-7825
Éditeur: Elsevier BV
DOI: 10.1016/j.cma.2020.113506

Integration of activation maps of epicardial veins in computational cardiac electrophysiology

Auteurs: Simone Stella; Christian Vergara; Massimiliano Maines; Domenico Catanzariti; Pasquale Claudio Africa; Cristina Dematte; Maurizio Centonze; Fabio Nobile; Maurizio Del Greco; Alfio Quarteroni; Alfio Quarteroni
Publié dans: Computers in Biology and Medicine, Numéro Volume 127, December 2020, 104047, 2020, ISSN 0010-4825
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2020.104047

3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics

Auteurs: Roberto Piersanti; Francesco Regazzoni; Matteo Salvador; Antonio F. Corno; Luca Dede’; Christian Vergara; Alfio Quarteroni
Publié dans: Computer Methods in Applied Mechanics and Engineering, 2022, ISSN 0045-7825
Éditeur: Elsevier BV
DOI: 10.1016/j.cma.2022.114607

A physics-informed multi-fidelity approach for the estimation of differential equations parameters in low-data or large-noise regimes

Auteurs: Regazzoni, Francesco; Pagani, Stefano; Cosenza, Alessandro; Lombardi, Alessandro; Quarteroni, Alfio
Publié dans: Rendiconti Lincei. Matematica e Applicazioni, Numéro Atti Accad. Naz. Lincei Cl. Sci. Fis. Mat. Natur. 32 (2021), no. 3, 2021, Page(s) 437–470, ISSN 1120-6330
Éditeur: Accademia Nazionale dei Lincei
DOI: 10.4171/rlm/943

Electromechanical modeling of human ventricles with ischemic cardiomyopathy: numerical simulations in sinus rhythm and under arrhythmia

Auteurs: Matteo Salvador; Marco Fedele; Pasquale Claudio Africa; Eric Sung; Luca Dedè; Adityo Prakosa; Jonathan Chrispin; Natalia A. Trayanova; Alfio Quarteroni
Publié dans: Computers in Biology and Medicine, Numéro 4, 2021, ISSN 0010-4825
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.104674

Computational electrophysiology of the coronary sinus branches based on electro-anatomical mapping for the prediction of the latest activated region

Auteurs: Vergara C., Stella S., Maines M., Africa P.C., Catanzariti D., Dematte' C., Centonze M., Nobile F., Quarteroni A., Del Greco M.,
Publié dans: Medical & Biological Engineering & Computing, Numéro 60, 2022, Page(s) 2307-2319, ISSN 0140-0118
Éditeur: Institute of Electrical Engineers
DOI: 10.1007/s11517-022-02610-3

Mathematical analysis and numerical approximation of a general linearized poro-hyperelastic model

Auteurs: Nicolás Barnafi, Paolo Zunino, Luca Dedè, Alfio Quarteroni
Publié dans: Computers & Mathematics with Applications, 2020, Page(s) 1-27, ISSN 0898-1221
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.camwa.2020.07.025

Projection-based reduced order models for parameterized nonlinear time-dependent problems arising in cardiac mechanics

Auteurs: Cicci, Ludovica; Fresca, Stefania; Pagani, Stefano; Manzoni, Andrea; Quarteroni, Alfio
Publié dans: Mathematics in Engineering, Numéro 2023, Volume 5, Numéro 2, 2023, Page(s) 1-38, ISSN 2640-3501
Éditeur: AIMS press
DOI: 10.3934/mine.2023026

Image-Based Computational Hemodynamics Analysis of Systolic Obstruction in Hypertrophic Cardiomyopathy

Auteurs: Ivan Fumagalli; Piermario Vitullo; Christian Vergara; Marco Fedele; Antonio F. Corno; Sonia Ippolito; Roberto Scrofani; Alfio Quarteroni; Alfio Quarteroni
Publié dans: Frontiers in Physiology, 2022, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.787082

Data integration for the numerical simulation of cardiac electrophysiology.

Auteurs: Stefano Pagani; Luca Dedè; Andrea Manzoni; Alfio Quarteroni; Alfio Quarteroni
Publié dans: Pacing and Clinical Electrophysiology, Numéro 5, 2021, ISSN 0147-8389
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/pace.14198

A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

Auteurs: Fedele, Marco; Piersanti, Roberto; Regazzoni, Francesco; Salvador, Matteo; Africa, Pasquale; Bucelli, Michele; Zingaro, Alberto; Dede', Luca; Quarteroni, Alfio
Publié dans: Computer Methods in Applied Mechanics and Engineering, Numéro Volume 410, 15 May 2023, 2023, ISSN 0045-7825
Éditeur: Elsevier BV
DOI: 10.1016/j.cma.2023.115983

Hemodynamics of the heart's left atrium based on a Variational Multiscale-LES numerical method

Auteurs: Alberto Zingaro; Luca Dede'; F. Menghini; Alfio Quarteroni; Alfio Quarteroni
Publié dans: European Journal of Mechanics - B/Fluids, Numéro Volume 89, September–October 2021, 2021, Page(s) 380-400, ISSN 0997-7546
Éditeur: Elsevier BV
DOI: 10.1016/j.euromechflu.2021.06.014

A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation

Auteurs: Pagani, S.; Dede', L.; Frontera, A.; Salvador, M.; Limite, L. R.; Manzoni, A.; Lipartiti, F.; Tsitsinakis, G.; Hadjis, A.; Della Bella, P.; Quarteroni, A.
Publié dans: Frontiers in Physiology, Numéro vol. 10, 2021, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.673612

Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction

Auteurs: Francesco Regazzoni, Luca Dedè, Alfio Quarteroni
Publié dans: Vietnam Journal of Mathematics, 2020, ISSN 2305-221X
Éditeur: Springer Science + Business Media
DOI: 10.1007/s10013-020-00433-z

POD-Enhanced Deep Learning-Based Reduced Order Models for the Real-Time Simulation of Cardiac Electrophysiology in the Left Atrium.

Auteurs: Stefania Fresca; Andrea Manzoni; Luca Dedè; Alfio Quarteroni; Alfio Quarteroni
Publié dans: Frontiers in Physiology, Numéro 6, 2021, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.679076

Multipatch Isogeometric Analysis for electrophysiology: Simulation in a human heart

Auteurs: Michele Bucelli, Matteo Salvador, Luca Dedè, Alfio Quarteroni
Publié dans: Computer Methods in Applied Mechanics and Engineering, Numéro Volume 376, 1 April 2021, 2021, Page(s) 113666, ISSN 0045-7825
Éditeur: Elsevier BV
DOI: 10.1016/j.cma.2021.113666

Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function

Auteurs: Marco Fedele, Alfio Quarteroni
Publié dans: International Journal for Numerical Methods in Biomedical Engineering, 2021, ISSN 2040-7947
Éditeur: John Wiley & Sons Ltd
DOI: 10.1002/cnm.3435

Enabling forward uncertainty quantification and sensitivity analysis in cardiac electrophysiology by reduced order modeling and machine learning.

Auteurs: Stefano Pagani; Andrea Manzoni
Publié dans: International Journal for Numerical Methods in Biomedical Engineering, 2021, ISSN 2040-7947
Éditeur: John Wiley & Sons Ltd
DOI: 10.1002/cnm.3450

Deep learning-based reduced order models in cardiac electrophysiology

Auteurs: Fresca, S.; Manzoni, A.; Dedè, L.; Quarteroni, A.
Publié dans: PLOS One, Numéro 15, 10, 2020, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0239416

A computational model applied to myocardial perfusion in the human heart: From large coronaries to microvasculature

Auteurs: Di Gregorio Simone, Fedele Marco, Pontone Gianluca, Corno,Antonio, Zunino Paolo, Vergara Christian, Quarteroni Alfio
Publié dans: JOURNAL OF COMPUTATIONAL PHYSICS, Numéro 424, 2021, Page(s) 109836-109859, ISSN 0021-9991
Éditeur: Academic Press
DOI: 10.1016/j.jcp.2020.109836

PDE-Aware Deep Learning for Inverse Problems in Cardiac Electrophysiology

Auteurs: Riccardo Tenderini; Stefano Pagani; Alfio Quarteroni; Simone Deparis
Publié dans: SIAM Journal on Scientific Computing, Numéro Vol. 44, Iss. 3 (2022), 2022, ISSN 1064-8275
Éditeur: Society for Industrial and Applied Mathematics
DOI: 10.1137/21m1438529

Fluid-structure interaction analysis of transcatheter aortic valve implantation

Auteurs: Fumagalli, Ivan; Polidori, Rebecca; Renzi, Francesca; Fusini, Laura; Quarteroni, Alfio; Pontone, Gianluca; Vergara, Christian
Publié dans: International Journal for Numerical Methods in Biomedical Engineering, Numéro e3704, 2023, ISSN 2040-7947
Éditeur: Wiley
DOI: 10.1002/cnm.3704

An image-based computational hemodynamics study of the Systolic Anterior Motion of the mitral valve

Auteurs: Ivan Fumagalli, Marco Fedele, Christian Vergara, Luca Dedè, Sonia Ippolito, Francesca Nicolò, Carlo Antona, Roberto Scrofani, Alfio Quarteroni
Publié dans: Computers in Biology and Medicine, Numéro Volume 123, August 2020, 103922, 2020, ISSN 0010-4825
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2020.103922

lifex: A flexible, high performance library for the numerical solution of complex finite element problems

Auteurs: Pasquale Claudio Africa
Publié dans: SoftwareX, Numéro vol. 23 (2023), 2023, ISSN 2352-7110
Éditeur: Elsevier
DOI: 10.1016/j.softx.2022.101252

A machine learning method for real-time numerical simulations of cardiac electromechanics

Auteurs: F. Regazzoni; M. Salvador; L. Dede’; A. Quarteroni
Publié dans: COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, 2022, ISSN 0045-7825
Éditeur: Elsevier BV
DOI: 10.1016/j.cma.2022.114825

The role of mechano-electric feedbacks and hemodynamic coupling in scar-related ventricular tachycardia

Auteurs: Matteo Salvador; Francesco Regazzoni; Stefano Pagani; Luca Dede'; Natalia Trayanova; Alfio Quarteroni
Publié dans: Computers in Biology and Medicine, Numéro 6, 2022, ISSN 0010-4825
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2021.105203

Partitioned and monolithic algorithms for the numerical solution of cardiac fluid-structure interaction

Auteurs: Michele Bucelli, Luca Dede', Alfio Quarteroni, Christian Vergara
Publié dans: Communications in Computational Physics, Numéro 32 (2022), 2022, Page(s) 1217-1256, ISSN 1815-2406
Éditeur: Global Science Press
DOI: 10.4208/cicp.oa-2021-0243

lifex-fiber: an open tool for myofibers generation in cardiac computational models

Auteurs: Pasquale Claudio Africa, Roberto Piersanti, Marco Fedele, Luca Dede’ , Alfio Quarteroni
Publié dans: BMC Bioinformatics, Numéro 24 (1):143, 2023, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/s12859-023-05260-w

A mathematical model that integrates cardiac electrophysiology, mechanics and fluid dynamics: application to the human left heart

Auteurs: Michele Bucelli; Alberto Zingaro; Pasquale Claudio Africa; Ivan Fumagalli; Luca Dede'; Alfio Quarteroni
Publié dans: International Journal for Numerical Methods in Biomedical Engineering, Numéro 1, 2023, Page(s) Volume39, Numéro3, March 2023, e3678, ISSN 2040-7947
Éditeur: Wiley
DOI: 10.1002/cnm.3678

The Impact of Left Atrium Appendage Morphology on Stroke Risk Assessment in Atrial Fibrillation: A Computational Fluid Dynamics Study

Auteurs: Alessandro Masci, Lorenzo Barone, Luca Dedè, Marco Fedele, Corrado Tomasi, Alfio Quarteroni, Cristiana Corsi
Publié dans: Frontiers in Physiology, Numéro 9, 2019, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2018.01938

Isogeometric Analysis of the electrophysiology in the human heart: Numerical simulation of the bidomain equations on the atria

Auteurs: Luca Pegolotti, Luca Dedè, Alfio Quarteroni
Publié dans: Computer Methods in Applied Mechanics and Engineering, Numéro 343, 2019, Page(s) 52-73, ISSN 0045-7825
Éditeur: Elsevier BV
DOI: 10.1016/j.cma.2018.08.032

A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation

Auteurs: Luca Barbarotta, Simone Rossi, Luca Dedè, Alfio Quarteroni
Publié dans: International Journal for Numerical Methods in Biomedical Engineering, Numéro 34/12, 2018, Page(s) e3137, ISSN 2040-7939
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3137

A monolithic algorithm for the simulation of cardiac electromechanics in the human left ventricle

Auteurs: Antonello Gerbi, Luca Dede’, Alfio Quarteroni
Publié dans: Mathematics in Engineering, Numéro 1/1, 2018, Page(s) 1-37, ISSN 2640-3501
Éditeur: AIMS Press
DOI: 10.3934/mine.2018.1.1

Numerical approximation of parametrized problems in cardiac electrophysiology by a local reduced basis method

Auteurs: Stefano Pagani, Andrea Manzoni, Alfio Quarteroni
Publié dans: Computer Methods in Applied Mechanics and Engineering, Numéro 340, 2018, Page(s) 530-558, ISSN 0045-7825
Éditeur: Elsevier BV
DOI: 10.1016/j.cma.2018.06.003

Biophysically detailed mathematical models of multiscale cardiac active mechanics

Auteurs: Francesco Regazzoni, Luca Dedè, Alfio Quarteroni
Publié dans: PLOS Computational Biology, Numéro 16/10, 2020, Page(s) e1008294, ISSN 1553-734X
Éditeur: Public Library of Science
DOI: 10.1371/journal.pcbi.1008294

Computational fluid dynamics of blood flow in an idealized left human heart

Auteurs: Luca Dedè, Filippo Menghini, Alfio Quarteroni
Publié dans: International Journal for Numerical Methods in Biomedical Engineering, 2019, ISSN 2040-7939
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.3287

An intergrid transfer operator using radial basis functions with application to cardiac electromechanics

Auteurs: Matteo Salvador, Luca Dede', Alfio Quarteroni
Publié dans: Computational Mechanics, Numéro Volume 66, Numéro 1, July 2020, 2020, ISSN 0178-7675
Éditeur: Springer Verlag

Machine learning of multiscale active force generation models for the efficient simulation of cardiac electromechanics

Auteurs: F. Regazzoni, L. Dedè, A. Quarteroni
Publié dans: Computer Methods in Applied Mechanics and Engineering, Numéro 370, 2020, Page(s) 113268, ISSN 0045-7825
Éditeur: Elsevier BV
DOI: 10.1016/j.cma.2020.113268

Mathematical and numerical models for the cardiac electromechanical function

Auteurs: Luca Dedè; Alfio Quarteroni; Francesco Regazzoni
Publié dans: Atti Accademia Nazionale dei Lincei, Numéro Classe Scienze Fisiche Matematiche Naturali 32 (2021), no. 2, 2021, Page(s) 233-272, ISSN 1120-6330
Éditeur: Accademia Nazionale dei Lincei
DOI: 10.4171/rlm/935

Modeling the cardiac electromechanical function: A mathematical journey

Auteurs: Alfio Quarteroni; Luca Dedè; Francesco Regazzoni
Publié dans: Bulletin of the American Mathematical Society, Numéro 59 (2022), 2022, Page(s) 371-403, ISSN 0273-0979
Éditeur: American Mathematical Society
DOI: 10.1090/bull/1738

A stable loosely-coupled scheme for cardiac electro-fluid-structure interaction

Auteurs: Michele Bucelli , Martin Geraint Gabriel , Alfio Quarteroni , Giacomo Gigante , Christian Vergara
Publié dans: Journal of Computational Physics, Numéro Volume 490, 1 October 2023, 112326, 2023, ISSN 0021-9991
Éditeur: Academic Press
DOI: 10.1016/j.jcp.2023.112326

Deep-HyROMnet: A Deep Learning-Based Operator Approximation for Hyper-Reduction of Nonlinear Parametrized PDEs

Auteurs: Cicci, Ludovica; Fresca, Stefania; Manzoni, Andrea
Publié dans: Journal of Scientific Computing, Numéro 93, Article number: 57 (2022), 2022, ISSN 0885-7474
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10915-022-02001-8

Efficient and certified solution of parametrized one-way coupled problems through DEIM-based data projection across non-conforming interfaces

Auteurs: Elena Zappon, Andrea Manzoni, Alfio Quarteroni
Publié dans: Advances in Computational Mathematics, Numéro 49, 21, 2023, ISSN 1019-7168
Éditeur: Kluwer Academic Publishers
DOI: 10.48550/arxiv.2203.09226

A cardiac electromechanical model coupled with a lumped-parameter model for closed-loop blood circulation

Auteurs: F. Regazzoni; M. Salvador; P.C. Africa; M. Fedele; L. Dedè; A. Quarteroni
Publié dans: Journal of Computational Physics, Numéro 4, 2022, ISSN 0021-9991
Éditeur: Academic Press
DOI: 10.1016/j.jcp.2022.111083

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

Auteurs: Roberto Piersanti, Pasquale C. Africa, Marco Fedele, Christian Vergara, Luca Dedè, Antonio F. Corno, Alfio Quarteroni
Publié dans: Computer Methods in Applied Mechanics and Engineering, Numéro 373, 2021, Page(s) 113468, ISSN 0045-7825
Éditeur: Elsevier BV
DOI: 10.1016/j.cma.2020.113468

A geometric multiscale model for the numerical simulation of blood flow in the human left heart

Auteurs: Alberto Zingaro; Ivan Fumagalli; Luca Dede; Marco Fedele; Pasquale C. Africa; Antonio F. Corno; Alfio Quarteroni
Publié dans: Discrete and Continuous Dynamical Systems - Series S, Numéro 5, 2022, ISSN 1937-1632
Éditeur: American Institute of Mathematical Sciences
DOI: 10.3934/dcdss.2022052

Book chapters (1)

Segregated algorithms for the numerical simulation of cardiac electromechanics in the left human ventricle

Auteurs: L. Dede', A. Gerbi, A. Quarteroni
Publié dans: The Mathematics of Mechanobiology, 2020, Page(s) 81--116, ISBN 978-3-030-45196-7
Éditeur: Springer Verlag
DOI: 10.1007/978-3-030-45197-4_3