Volume regulation and extracellular signalling by anion channels

Project Information

VOLSIGNAL

Grant agreement ID: 740537

DOI

10.3030/740537

Project closed

EC signature date 12 July 2017

Start date 1 October 2017

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 991,00

EU contribution

€ 2 499 991,00

Coordinated by

FORSCHUNGSVERBUND BERLIN EV
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels

Author(s): Heng Liu, Maya M Polovitskaya, Linlin Yang, Meiling Li, Hongyue Li, Zhen Han, Jianguo Wu, Qiansen Zhang, Thomas J Jentsch, Jun Liao
Published in: Cell Reports, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112926

Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy

Author(s): Karen I. López-Cayuqueo, Rosa Planells-Cases, Matthias Pietzke, Anna Oliveras, Stefan Kempa, Sebastian Bachmann and Thomas J. Jentsch
Published in: Journal of the American Society of Nephrology, Issue 33/8, 2022, ISSN 1046-6673
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2021111458

LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs)

Author(s): Pingzheng Zhou, Maya M. Polovitskaya, Thomas J. Jentsch
Published in: Journal of Biological Chemistry, Issue 293/35, 2018, Page(s) 13440-13451, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.002853

LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion

Author(s): Till Stuhlmann, Rosa Planells-Cases, Thomas J. Jentsch
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04353-y

LRRC8/VRAC anion channels are required for late stages of spermatid development in mice

Author(s): Jennifer C. Lück, Dmytro Puchkov, Florian Ullrich, Thomas J. Jentsch
Published in: Journal of Biological Chemistry, Issue 293/30, 2018, Page(s) 11796-11808, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA118.003853

Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

Author(s): Florian Ullrich, Sandy Blin, Katina Lazarow, Tony Daubitz, Jens Peter von Kries, Thomas J Jentsch
Published in: eLife, Issue 8, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.49187

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

Author(s): Chun Zhou, Xia Chen, Rosa Planells-Cases, Jiachen Chu, Li Wang, Limin Cao, Zhihong Li, Karen I. López-Cayuqueo, Yadong Xie, Shiwei Ye, Xiang Wang, Florian Ullrich, Shixin Ma, Yiyuan Fang, Xiaoming Zhang, Zhikang Qian, Xiaozheng Liang, Shi-Qing Cai, Zhengfan Jiang, Dongming Zhou, Qibin Leng, Tsan S. Xiao, Ke Lan, Jinbo Yang, Huabin Li, Chao Peng, Zhaozhu Qiu, Thomas J. Jentsch, Hui Xiao
Published in: Immunity, Issue 52/5, 2020, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2020.03.016

Gating choreography and mechanism of the human proton-activated chloride channel ASOR

Author(s): Chongyuan Wang, Maya M. Polovitskaya, Bryce D. Delgado, Thomas J. Jentsch, Stephen B. Long
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abm3942

LRRC8/VRAC volume-regulated anion channels are crucial for hearing

Author(s): Deborah A. Knecht, Mariia Zeziulia, Mit B. Bhavsar, Dmytro Puchkov, Hannes Maier, Thomas J. Jentsch
Published in: Journal of Biological Chemistry, Issue 300, 2024, Page(s) 107436, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2024.107436

Proton-gated anion transport governs macropinosome shrinkage

Author(s): Mariia Zeziulia, Sandy Blin, Franziska W Schmitt, Martin Lehmann, Thomas J Jentsch
Published in: Nature Cell Biology, Issue 14657392, 2022, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-022-00912-0