Volume regulation and extracellular signalling by anion channels
Project information
VOLSIGNAL
Grant agreement ID: 740537
Status
Ongoing project
-
Start date
1 October 2017
-
End date
30 September 2022
Funded under:
H2020-EU.1.1.
-
Overall budget:
€ 2 499 991
-
EU contribution
€ 2 499 991
Objective
Research on cell volume regulation stagnated because the identity of a key player, the Volume-Regulated Anion Channel VRAC, remained unknown. Very recently we identified LRRC8 heteromers as VRAC components and discovered that VRACs are a heterogeneous group of channels. Their remarkable ability to transport not only Cl-, but also signalling molecules or drugs, depends on their LRRC8 subunit composition.
This breakthrough now allows us to search for functionally relevant interactors and to dissect the physiological roles of different VRACs using mouse models. Whereas disruption of Lrrc8a abolishes VRAC function, abrogating other Lrrc8 genes (in total five) will change its transport properties. Conditional KO mice will first focus on epithelia which faces large osmolarity changes, on the brain where VRAC-released signalling molecules are supposed to play important roles in physiology and pathology, and on VRAC’s assumed role in vesicle exocytosis. We expect to discover many surprising novel roles of VRACs.
Emboldened by our identification of VRAC, we will use genome-wide siRNA screens to identify two other ‘missing’ ion channels, which have been known physiologically for many years and may have widespread roles in signalling and other physiological processes. Once identified, these channels will be studied at a structural, cellular and organismal level.
These projects will break new ground in physiology, cell biology, signalling and pathology.
Field of Science
/natural sciences/biological sciences/cell biology
/medical and health sciences/basic medicine/pathology
/social sciences/sociology/social problems/migration
/social sciences/social and economic geography/transport
/medical and health sciences/basic medicine/physiology
Topic(s)
Funding Scheme
ERC-ADG - Advanced Grant
Host institution
FORSCHUNGSVERBUND BERLIN EV
Address
Rudower Chaussee 17
12489 Berlin
Germany
Activity type
Research Organisations
EU Contribution
€ 2 499 991
Beneficiaries (1)
FORSCHUNGSVERBUND BERLIN EV
Germany
EU Contribution
€ 2 499 991
Project information
VOLSIGNAL
Grant agreement ID: 740537
Status
Ongoing project
-
Start date
1 October 2017
-
End date
30 September 2022
Funded under:
H2020-EU.1.1.
-
Overall budget:
€ 2 499 991
-
EU contribution
€ 2 499 991
Project information
VOLSIGNAL
Grant agreement ID: 740537
Status
Ongoing project
-
Start date
1 October 2017
-
End date
30 September 2022
Funded under:
H2020-EU.1.1.
-
Overall budget:
€ 2 499 991
-
EU contribution
€ 2 499 991
Project information
VOLSIGNAL
Grant agreement ID: 740537
Status
Ongoing project
-
Start date
1 October 2017
-
End date
30 September 2022
Funded under:
H2020-EU.1.1.
-
Overall budget:
€ 2 499 991
-
EU contribution
€ 2 499 991
Project information
VOLSIGNAL
Grant agreement ID: 740537
Status
Ongoing project
-
Start date
1 October 2017
-
End date
30 September 2022
Funded under:
H2020-EU.1.1.
-
Overall budget:
€ 2 499 991
-
EU contribution
€ 2 499 991
Deliverables
Deliverables not available
Publications
Project information
VOLSIGNAL
Grant agreement ID: 740537
Status
Ongoing project
-
Start date
1 October 2017
-
End date
30 September 2022
Funded under:
H2020-EU.1.1.
-
Overall budget:
€ 2 499 991
-
EU contribution
€ 2 499 991
Project information
VOLSIGNAL
Grant agreement ID: 740537
Status
Ongoing project
-
Start date
1 October 2017
-
End date
30 September 2022
Funded under:
H2020-EU.1.1.
-
Overall budget:
€ 2 499 991
-
EU contribution
€ 2 499 991
Project information
VOLSIGNAL
Grant agreement ID: 740537
Status
Ongoing project
-
Start date
1 October 2017
-
End date
30 September 2022
Funded under:
H2020-EU.1.1.
-
Overall budget:
€ 2 499 991
-
EU contribution
€ 2 499 991
