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Volume regulation and extracellular signalling by anion channels

Pubblicazioni

Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels

Autori: Heng Liu, Maya M Polovitskaya, Linlin Yang, Meiling Li, Hongyue Li, Zhen Han, Jianguo Wu, Qiansen Zhang, Thomas J Jentsch, Jun Liao
Pubblicato in: Cell Reports, 2023, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.112926

Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy

Autori: Karen I. López-Cayuqueo, Rosa Planells-Cases, Matthias Pietzke, Anna Oliveras, Stefan Kempa, Sebastian Bachmann and Thomas J. Jentsch
Pubblicato in: Journal of the American Society of Nephrology, Issue 10466673, 2022, ISSN 1046-6673
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2021111458

LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs)

Autori: Pingzheng Zhou, Maya M. Polovitskaya, Thomas J. Jentsch
Pubblicato in: Journal of Biological Chemistry, Issue 293/35, 2018, Page(s) 13440-13451, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.002853

LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion

Autori: Till Stuhlmann, Rosa Planells-Cases, Thomas J. Jentsch
Pubblicato in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-04353-y

LRRC8/VRAC anion channels are required for late stages of spermatid development in mice

Autori: Jennifer C. Lück, Dmytro Puchkov, Florian Ullrich, Thomas J. Jentsch
Pubblicato in: Journal of Biological Chemistry, Issue 293/30, 2018, Page(s) 11796-11808, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA118.003853

Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

Autori: Florian Ullrich, Sandy Blin, Katina Lazarow, Tony Daubitz, Jens Peter von Kries, Thomas J Jentsch
Pubblicato in: eLife, Issue 8, 2019, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.49187

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

Autori: Chun Zhou, Xia Chen, Rosa Planells-Cases, Jiachen Chu, Li Wang, Limin Cao, Zhihong Li, Karen I. López-Cayuqueo, Yadong Xie, Shiwei Ye, Xiang Wang, Florian Ullrich, Shixin Ma, Yiyuan Fang, Xiaoming Zhang, Zhikang Qian, Xiaozheng Liang, Shi-Qing Cai, Zhengfan Jiang, Dongming Zhou, Qibin Leng, Tsan S. Xiao, Ke Lan, Jinbo Yang, Huabin Li, Chao Peng, Zhaozhu Qiu, Thomas J. Jentsch, Hui Xiao
Pubblicato in: Immunity, 2020, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2020.03.016

Gating choreography and mechanism of the human proton-activated chloride channel ASOR

Autori: Chongyuan Wang, Maya M. Polovitskaya, Bryce D. Delgado, Thomas J. Jentsch, Stephen B. Long
Pubblicato in: Science Advances, 2022, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.abm3942

Proton-gated anion transport governs macropinosome shrinkage

Autori: Mariia Zeziulia, Sandy Blin, Franziska W Schmitt, Martin Lehmann, Thomas J Jentsch
Pubblicato in: Nature Cell Biology, Issue 14657392, 2022, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-022-00912-0

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