Volume regulation and extracellular signalling by anion channels

Información del proyecto

VOLSIGNAL

Identificador del acuerdo de subvención: 740537

DOI 10.3030/740537

Fecha de la firma de la CE 12 Julio 2017

Fecha de inicio 1 Octubre 2017

Fecha de finalización 30 Junio 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 2 499 991,00

Aportación de la UE € 2 499 991,00

Coordinado por

FORSCHUNGSVERBUND BERLIN EV
Germany

Publicaciones

Peer reviewed articles (9)

Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels

Autores: Heng Liu, Maya M Polovitskaya, Linlin Yang, Meiling Li, Hongyue Li, Zhen Han, Jianguo Wu, Qiansen Zhang, Thomas J Jentsch, Jun Liao
Publicado en: Cell Reports, 2023, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112926

Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy

Autores: Karen I. López-Cayuqueo, Rosa Planells-Cases, Matthias Pietzke, Anna Oliveras, Stefan Kempa, Sebastian Bachmann and Thomas J. Jentsch
Publicado en: Journal of the American Society of Nephrology, Edición 10466673, 2022, ISSN 1046-6673
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1681/asn.2021111458

LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs)

Autores: Pingzheng Zhou, Maya M. Polovitskaya, Thomas J. Jentsch
Publicado en: Journal of Biological Chemistry, Edición 293/35, 2018, Página(s) 13440-13451, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.002853

LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion

Autores: Till Stuhlmann, Rosa Planells-Cases, Thomas J. Jentsch
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-04353-y

LRRC8/VRAC anion channels are required for late stages of spermatid development in mice

Autores: Jennifer C. Lück, Dmytro Puchkov, Florian Ullrich, Thomas J. Jentsch
Publicado en: Journal of Biological Chemistry, Edición 293/30, 2018, Página(s) 11796-11808, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.RA118.003853

Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

Autores: Florian Ullrich, Sandy Blin, Katina Lazarow, Tony Daubitz, Jens Peter von Kries, Thomas J Jentsch
Publicado en: eLife, Edición 8, 2019, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.49187

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

Autores: Chun Zhou, Xia Chen, Rosa Planells-Cases, Jiachen Chu, Li Wang, Limin Cao, Zhihong Li, Karen I. López-Cayuqueo, Yadong Xie, Shiwei Ye, Xiang Wang, Florian Ullrich, Shixin Ma, Yiyuan Fang, Xiaoming Zhang, Zhikang Qian, Xiaozheng Liang, Shi-Qing Cai, Zhengfan Jiang, Dongming Zhou, Qibin Leng, Tsan S. Xiao, Ke Lan, Jinbo Yang, Huabin Li, Chao Peng, Zhaozhu Qiu, Thomas J. Jentsch, Hui Xiao
Publicado en: Immunity, 2020, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2020.03.016

Gating choreography and mechanism of the human proton-activated chloride channel ASOR

Autores: Chongyuan Wang, Maya M. Polovitskaya, Bryce D. Delgado, Thomas J. Jentsch, Stephen B. Long
Publicado en: Science Advances, 2022, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.abm3942

Proton-gated anion transport governs macropinosome shrinkage

Autores: Mariia Zeziulia, Sandy Blin, Franziska W Schmitt, Martin Lehmann, Thomas J Jentsch
Publicado en: Nature Cell Biology, Edición 14657392, 2022, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-022-00912-0