INTEGRATION AND PROPAGATION OF IMMUNOLOGICAL SIGNALS DURING CANCER AND INFECTION

Projektinformationen

ENLIGHTEN

ID Finanzhilfevereinbarung: 741167

DOI 10.3030/741167

Abgeschlossenes Projekt

EK-Unterschriftsdatum 30 Mai 2017

Startdatum 1 Januar 2018

Enddatum 31 Dezember 2023

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 2 499 994,00

EU-Beitrag € 2 499 994,00

Koordiniert durch

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Ziel

The immune system uses both short- and long-range communication mechanisms to mount the coordinated and sophisticated cellular responses required to control microbial infections or fight tumors. Yet, our understanding of how immunological signals are integrated and propagated by individual cells in complex tissue microenvironments remains largely limited.

ENLIGHTEN is a research program dedicated to establish new mechanisms by which the immune system fight tumors or infections, based on the direct manipulation of immunological signals in vivo. In relevant mouse models of human disease, we will combine intravital imaging, fluorescent sensors and optogenetic actuators to control single cell functions in real-time. We wish to understand how T cells sense and interpret cell-contacts in lymphoid organs and in developing tumors at steady state or during immunotherapy. In addition, we aim to establish how cytokine and chemokine gradients form in tissues and are interpreted by immune cells during infection or cancer.

By determining the functional contribution of single immune cells in vivo, we aim to identify new paradigms for information transfer in the immune system during cancer or infection and to establish the combination of optogenetics and intravital imaging as a powerful strategy for decoding immune reactions in the context of disease pathogenesis.

Wissenschaftliches Gebiet

• natural sciences › physical sciences › optics › microscopy
• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors
• medical and health sciences › clinical medicine › oncology
• medical and health sciences › basic medicine › immunology › immunotherapy

Schlüsselbegriffe

• tumor immunity
• immunity to infection
• intravital imaging
• optogenetics
• cytokines
• chemokines

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-2016-ADG - ERC Advanced Grant

Aufforderung zur Vorschlagseinreichung

ERC-2016-ADG

Finanzierungsplan

ERC-ADG - Advanced Grant

Gastgebende Einrichtung

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

• Netto-EU-Beitrag: € 2 499 994,00
• Adresse: RUE DE TOLBIAC 101 ; 75654 Paris ; Frankreich
• Region: Ile-de-France › Ile-de-France › Paris
• Aktivitätstyp: Research Organisations
• Gesamtkosten: € 2 499 994,00

Begünstigte (1)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Frankreich

• Netto-EU-Beitrag: € 2 499 994,00
• Adresse: RUE DE TOLBIAC 101 ; 75654 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Aktivitätstyp: Research Organisations
• Gesamtkosten: € 2 499 994,00