Developing Geroprotectors to Prevent Polymorbidity

Project Information

GeroProtect

Grant agreement ID: 741989

DOI 10.3030/741989

Project closed

EC signature date 9 November 2017

Start date 1 December 2017

End date 30 November 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

Publications

Peer reviewed articles (10)

PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults

Author(s): Fatih A. Bogaards, Thies Gehrmann, Marian Beekman, Erik Ben van den Akker, Ondine van de Rest, Roland W.J. Hangelbroek, Raymond Noordam, simon P. Moooijaart, Lisette C. P. G. M. de Groot, Marcel J. T. Reinders, P. Eline Slagboom
Published in: The FASEB Journal, Issue 36(11):e22578, 2022, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202201037r

Biological mechanisms of aging predict age-related disease co-occurrence in patients

Author(s): Helen C Fraser, Valerie Kuan, Ronja Johnen, Magdalena Zwierzyna, Aroon D Hingorani, Andreas Beyer, Linda Partridge
Published in: Aging Cell, Issue 21, 2022, Page(s) e13524, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13524

Lithium can mildly increase health during ageing but not lifespan in mice

Author(s): Tobias Nespital; Brit Neuhaus; Andrea Mesaros; André Pahl; Linda Partridge
Published in: Aging Cell, Issue 20, 2021, Page(s) e13479, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13479

Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy

Author(s): Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F. Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C. Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge
Published in: Nature Aging, Issue 2, 2022, Page(s) 824–836, ISSN 2662-8465
Publisher: Nature Springer
DOI: 10.1038/s43587-022-00278-w

Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin

Author(s): Jennifer C. Regan, Yu-Xuan Lu, Enric Urena, Ralf L. Meilenbrock, James H. Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk & Linda Partridge
Published in: Nature Aging, Issue 2, 2022, Page(s) 1145-1158, ISSN 2662-8465
Publisher: Springer Nature
DOI: 10.1038/s43587-022-00308-7

From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing

Author(s): Maarouf Baghdadi, Helena M. Hinterding, Linda Partridge, Joris Deelen
Published in: Briefings in Functional Genomics, Issue 21, 2022, Page(s) 13-23, ISSN 2041-2649
Publisher: Oxford University Press
DOI: 10.1093/bfgp/elab005

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing.

Author(s): Yu-Xuan Lu; Jennifer C. Regan; Jacqueline Eßer; Lisa F Drews; Thomas Weinseis; Julia Stinn; Oliver Hahn; Richard A. Miller; Sebastian Grönke; Linda Partridge; Linda Partridge
Published in: eLife, Issue 10, 2021, Page(s) e62233, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.62233

Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production

Author(s): Luke S. Tain, Chirag Jain, Tobias Nespital, Jenny Froehlich, Yvonne Hinze, Sebastian Grönke, Linda Partridge
Published in: Aging Cell, Issue 19/1, 2019, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13043

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

Author(s): Jorge Iván Castillo-Quan, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, Linda Partridge
Published in: Proceedings of the National Academy of Sciences, Issue 116/42, 2019, Page(s) 20817-20819, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1913212116

Horizons in the evolution of aging

Author(s): Thomas Flatt, Linda Partridge
Published in: BMC Biology, Issue 16/1, 2018, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-018-0562-z

Non-peer reviewed articles (2)

The quest to slow ageing through drug discovery

Author(s): Linda Partridge, Matias Fuentealba, Brian K. Kennedy
Published in: Nature Reviews Drug Discovery, 2020, ISSN 1474-1776
Publisher: Nature Publishing Group
DOI: 10.1038/s41573-020-0067-7

Facing up to the global challenges of ageing

Author(s): Linda Partridge, Joris Deelen, P. Eline Slagboom
Published in: Nature, Issue 561/7721, 2018, Page(s) 45-56, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0457-8

Other (1)

A combined lifestyle intervention induces a sensitization of the blood transcriptomic response to a nutrient challenge

Author(s): Thies Gehrmann, Marian Beekman, Joris Deelen, Linda Partridge, Ondine van de Rest, Leon Mei, Yotam Raz, Lisette de Groot, Ruud van der Breggen, Marcel J. T. Reinders, Erik B. van den Akker, P. Eline Slagboom
Published in: bioRxiv - The Preprint Server For Biology, 2021
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.05.18.444591