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Developing Geroprotectors to Prevent Polymorbidity

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Publications

Biological mechanisms of aging predict age-related disease co-occurrence in patients

Author(s): Helen C Fraser, Valerie Kuan, Ronja Johnen, Magdalena Zwierzyna, Aroon D Hingorani, Andreas Beyer, Linda Partridge
Published in: Aging Cell, 21, 2022, Page(s) e13524, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13524

Lithium can mildly increase health during ageing but not lifespan in mice

Author(s): Tobias Nespital; Brit Neuhaus; Andrea Mesaros; André Pahl; Linda Partridge
Published in: Aging Cell, 20, 2021, Page(s) e13479, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13479

From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing

Author(s): Maarouf Baghdadi, Helena M. Hinterding, Linda Partridge, Joris Deelen
Published in: Briefings in Functional Genomics, 21, 2022, Page(s) 13-23, ISSN 2041-2649
Publisher: Oxford University Press
DOI: 10.1093/bfgp/elab005

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing.

Author(s): Yu-Xuan Lu; Jennifer C. Regan; Jacqueline Eßer; Lisa F Drews; Thomas Weinseis; Julia Stinn; Oliver Hahn; Richard A. Miller; Sebastian Grönke; Linda Partridge; Linda Partridge
Published in: eLife, 10, 2021, Page(s) e62233, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.62233

Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production

Author(s): Luke S. Tain, Chirag Jain, Tobias Nespital, Jenny Froehlich, Yvonne Hinze, Sebastian Grönke, Linda Partridge
Published in: Aging Cell, 19/1, 2019, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13043

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

Author(s): Jorge Iván Castillo-Quan, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, Linda Partridge
Published in: Proceedings of the National Academy of Sciences, 116/42, 2019, Page(s) 20817-20819, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1913212116

Horizons in the evolution of aging

Author(s): Thomas Flatt, Linda Partridge
Published in: BMC Biology, 16/1, 2018, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-018-0562-z

The quest to slow ageing through drug discovery

Author(s): Linda Partridge, Matias Fuentealba, Brian K. Kennedy
Published in: Nature Reviews Drug Discovery, 2020, ISSN 1474-1776
Publisher: Nature Publishing Group
DOI: 10.1038/s41573-020-0067-7

Facing up to the global challenges of ageing

Author(s): Linda Partridge, Joris Deelen, P. Eline Slagboom
Published in: Nature, 561/7721, 2018, Page(s) 45-56, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0457-8