Developing Geroprotectors to Prevent Polymorbidity

PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults

Autores: Fatih A. Bogaards, Thies Gehrmann, Marian Beekman, Erik Ben van den Akker, Ondine van de Rest, Roland W.J. Hangelbroek, Raymond Noordam, simon P. Moooijaart, Lisette C. P. G. M. de Groot, Marcel J. T. Reinders, P. Eline Slagboom
Publicado en: The FASEB Journal, Edición 36(11):e22578, 2022, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202201037r

Biological mechanisms of aging predict age-related disease co-occurrence in patients

Autores: Helen C Fraser, Valerie Kuan, Ronja Johnen, Magdalena Zwierzyna, Aroon D Hingorani, Andreas Beyer, Linda Partridge
Publicado en: Aging Cell, Edición 21, 2022, Página(s) e13524, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.13524

Lithium can mildly increase health during ageing but not lifespan in mice

Autores: Tobias Nespital; Brit Neuhaus; Andrea Mesaros; André Pahl; Linda Partridge
Publicado en: Aging Cell, Edición 20, 2021, Página(s) e13479, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.13479

Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy

Autores: Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F. Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C. Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge
Publicado en: Nature Aging, Edición 2, 2022, Página(s) 824–836, ISSN 2662-8465
Editor: Nature Springer
DOI: 10.1038/s43587-022-00278-w

Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin

Autores: Jennifer C. Regan, Yu-Xuan Lu, Enric Urena, Ralf L. Meilenbrock, James H. Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk & Linda Partridge
Publicado en: Nature Aging, Edición 2, 2022, Página(s) 1145-1158, ISSN 2662-8465
Editor: Springer Nature
DOI: 10.1038/s43587-022-00308-7

From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing

Autores: Maarouf Baghdadi, Helena M. Hinterding, Linda Partridge, Joris Deelen
Publicado en: Briefings in Functional Genomics, Edición 21, 2022, Página(s) 13-23, ISSN 2041-2649
Editor: Oxford University Press
DOI: 10.1093/bfgp/elab005

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing.

Autores: Yu-Xuan Lu; Jennifer C. Regan; Jacqueline Eßer; Lisa F Drews; Thomas Weinseis; Julia Stinn; Oliver Hahn; Richard A. Miller; Sebastian Grönke; Linda Partridge; Linda Partridge
Publicado en: eLife, Edición 10, 2021, Página(s) e62233, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.62233

Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production

Autores: Luke S. Tain, Chirag Jain, Tobias Nespital, Jenny Froehlich, Yvonne Hinze, Sebastian Grönke, Linda Partridge
Publicado en: Aging Cell, Edición 19/1, 2019, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.13043

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

Autores: Jorge Iván Castillo-Quan, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, Linda Partridge
Publicado en: Proceedings of the National Academy of Sciences, Edición 116/42, 2019, Página(s) 20817-20819, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1913212116

Horizons in the evolution of aging

Autores: Thomas Flatt, Linda Partridge
Publicado en: BMC Biology, Edición 16/1, 2018, ISSN 1741-7007
Editor: BioMed Central
DOI: 10.1186/s12915-018-0562-z

The quest to slow ageing through drug discovery

Autores: Linda Partridge, Matias Fuentealba, Brian K. Kennedy
Publicado en: Nature Reviews Drug Discovery, 2020, ISSN 1474-1776
Editor: Nature Publishing Group
DOI: 10.1038/s41573-020-0067-7

Facing up to the global challenges of ageing

Autores: Linda Partridge, Joris Deelen, P. Eline Slagboom
Publicado en: Nature, Edición 561/7721, 2018, Página(s) 45-56, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-018-0457-8

A combined lifestyle intervention induces a sensitization of the blood transcriptomic response to a nutrient challenge

Autores: Thies Gehrmann, Marian Beekman, Joris Deelen, Linda Partridge, Ondine van de Rest, Leon Mei, Yotam Raz, Lisette de Groot, Ruud van der Breggen, Marcel J. T. Reinders, Erik B. van den Akker, P. Eline Slagboom
Publicado en: bioRxiv - The Preprint Server For Biology, 2021
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.05.18.444591

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