Developing Geroprotectors to Prevent Polymorbidity

PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults

Autorzy: Fatih A. Bogaards, Thies Gehrmann, Marian Beekman, Erik Ben van den Akker, Ondine van de Rest, Roland W.J. Hangelbroek, Raymond Noordam, simon P. Moooijaart, Lisette C. P. G. M. de Groot, Marcel J. T. Reinders, P. Eline Slagboom
Opublikowane w: The FASEB Journal, Numer 36(11):e22578, 2022, ISSN 0892-6638
Wydawca: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202201037r

Biological mechanisms of aging predict age-related disease co-occurrence in patients

Autorzy: Helen C Fraser, Valerie Kuan, Ronja Johnen, Magdalena Zwierzyna, Aroon D Hingorani, Andreas Beyer, Linda Partridge
Opublikowane w: Aging Cell, Numer 21, 2022, Strona(/y) e13524, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.13524

Lithium can mildly increase health during ageing but not lifespan in mice

Autorzy: Tobias Nespital; Brit Neuhaus; Andrea Mesaros; André Pahl; Linda Partridge
Opublikowane w: Aging Cell, Numer 20, 2021, Strona(/y) e13479, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.13479

Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy

Autorzy: Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F. Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C. Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge
Opublikowane w: Nature Aging, Numer 2, 2022, Strona(/y) 824–836, ISSN 2662-8465
Wydawca: Nature Springer
DOI: 10.1038/s43587-022-00278-w

Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin

Autorzy: Jennifer C. Regan, Yu-Xuan Lu, Enric Urena, Ralf L. Meilenbrock, James H. Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk & Linda Partridge
Opublikowane w: Nature Aging, Numer 2, 2022, Strona(/y) 1145-1158, ISSN 2662-8465
Wydawca: Springer Nature
DOI: 10.1038/s43587-022-00308-7

From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing

Autorzy: Maarouf Baghdadi, Helena M. Hinterding, Linda Partridge, Joris Deelen
Opublikowane w: Briefings in Functional Genomics, Numer 21, 2022, Strona(/y) 13-23, ISSN 2041-2649
Wydawca: Oxford University Press
DOI: 10.1093/bfgp/elab005

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing.

Autorzy: Yu-Xuan Lu; Jennifer C. Regan; Jacqueline Eßer; Lisa F Drews; Thomas Weinseis; Julia Stinn; Oliver Hahn; Richard A. Miller; Sebastian Grönke; Linda Partridge; Linda Partridge
Opublikowane w: eLife, Numer 10, 2021, Strona(/y) e62233, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.62233

Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production

Autorzy: Luke S. Tain, Chirag Jain, Tobias Nespital, Jenny Froehlich, Yvonne Hinze, Sebastian Grönke, Linda Partridge
Opublikowane w: Aging Cell, Numer 19/1, 2019, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.13043

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

Autorzy: Jorge Iván Castillo-Quan, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, Linda Partridge
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 116/42, 2019, Strona(/y) 20817-20819, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.1913212116

Horizons in the evolution of aging

Autorzy: Thomas Flatt, Linda Partridge
Opublikowane w: BMC Biology, Numer 16/1, 2018, ISSN 1741-7007
Wydawca: BioMed Central
DOI: 10.1186/s12915-018-0562-z

The quest to slow ageing through drug discovery

Autorzy: Linda Partridge, Matias Fuentealba, Brian K. Kennedy
Opublikowane w: Nature Reviews Drug Discovery, 2020, ISSN 1474-1776
Wydawca: Nature Publishing Group
DOI: 10.1038/s41573-020-0067-7

Facing up to the global challenges of ageing

Autorzy: Linda Partridge, Joris Deelen, P. Eline Slagboom
Opublikowane w: Nature, Numer 561/7721, 2018, Strona(/y) 45-56, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-018-0457-8

A combined lifestyle intervention induces a sensitization of the blood transcriptomic response to a nutrient challenge

Autorzy: Thies Gehrmann, Marian Beekman, Joris Deelen, Linda Partridge, Ondine van de Rest, Leon Mei, Yotam Raz, Lisette de Groot, Ruud van der Breggen, Marcel J. T. Reinders, Erik B. van den Akker, P. Eline Slagboom
Opublikowane w: bioRxiv - The Preprint Server For Biology, 2021
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.05.18.444591

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