Developing Geroprotectors to Prevent Polymorbidity

PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults

Autori: Fatih A. Bogaards, Thies Gehrmann, Marian Beekman, Erik Ben van den Akker, Ondine van de Rest, Roland W.J. Hangelbroek, Raymond Noordam, simon P. Moooijaart, Lisette C. P. G. M. de Groot, Marcel J. T. Reinders, P. Eline Slagboom
Pubblicato in: The FASEB Journal, Numero 36(11):e22578, 2022, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202201037r

Biological mechanisms of aging predict age-related disease co-occurrence in patients

Autori: Helen C Fraser, Valerie Kuan, Ronja Johnen, Magdalena Zwierzyna, Aroon D Hingorani, Andreas Beyer, Linda Partridge
Pubblicato in: Aging Cell, Numero 21, 2022, Pagina/e e13524, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.13524

Lithium can mildly increase health during ageing but not lifespan in mice

Autori: Tobias Nespital; Brit Neuhaus; Andrea Mesaros; André Pahl; Linda Partridge
Pubblicato in: Aging Cell, Numero 20, 2021, Pagina/e e13479, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.13479

Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy

Autori: Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F. Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C. Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge
Pubblicato in: Nature Aging, Numero 2, 2022, Pagina/e 824–836, ISSN 2662-8465
Editore: Nature Springer
DOI: 10.1038/s43587-022-00278-w

Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin

Autori: Jennifer C. Regan, Yu-Xuan Lu, Enric Urena, Ralf L. Meilenbrock, James H. Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk & Linda Partridge
Pubblicato in: Nature Aging, Numero 2, 2022, Pagina/e 1145-1158, ISSN 2662-8465
Editore: Springer Nature
DOI: 10.1038/s43587-022-00308-7

From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing

Autori: Maarouf Baghdadi, Helena M. Hinterding, Linda Partridge, Joris Deelen
Pubblicato in: Briefings in Functional Genomics, Numero 21, 2022, Pagina/e 13-23, ISSN 2041-2649
Editore: Oxford University Press
DOI: 10.1093/bfgp/elab005

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing.

Autori: Yu-Xuan Lu; Jennifer C. Regan; Jacqueline Eßer; Lisa F Drews; Thomas Weinseis; Julia Stinn; Oliver Hahn; Richard A. Miller; Sebastian Grönke; Linda Partridge; Linda Partridge
Pubblicato in: eLife, Numero 10, 2021, Pagina/e e62233, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.62233

Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production

Autori: Luke S. Tain, Chirag Jain, Tobias Nespital, Jenny Froehlich, Yvonne Hinze, Sebastian Grönke, Linda Partridge
Pubblicato in: Aging Cell, Numero 19/1, 2019, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.13043

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

Autori: Jorge Iván Castillo-Quan, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, Linda Partridge
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 116/42, 2019, Pagina/e 20817-20819, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1913212116

Horizons in the evolution of aging

Autori: Thomas Flatt, Linda Partridge
Pubblicato in: BMC Biology, Numero 16/1, 2018, ISSN 1741-7007
Editore: BioMed Central
DOI: 10.1186/s12915-018-0562-z

The quest to slow ageing through drug discovery

Autori: Linda Partridge, Matias Fuentealba, Brian K. Kennedy
Pubblicato in: Nature Reviews Drug Discovery, 2020, ISSN 1474-1776
Editore: Nature Publishing Group
DOI: 10.1038/s41573-020-0067-7

Facing up to the global challenges of ageing

Autori: Linda Partridge, Joris Deelen, P. Eline Slagboom
Pubblicato in: Nature, Numero 561/7721, 2018, Pagina/e 45-56, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-018-0457-8

A combined lifestyle intervention induces a sensitization of the blood transcriptomic response to a nutrient challenge

Autori: Thies Gehrmann, Marian Beekman, Joris Deelen, Linda Partridge, Ondine van de Rest, Leon Mei, Yotam Raz, Lisette de Groot, Ruud van der Breggen, Marcel J. T. Reinders, Erik B. van den Akker, P. Eline Slagboom
Pubblicato in: bioRxiv - The Preprint Server For Biology, 2021
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.05.18.444591

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