PRECISION CARE IN SYSTEMIC AUTOIMMUNITY: AN INTEGRATED MULTI-TISSUE/LEVEL APPROACH FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

Informations projet

LUPUSCARE

N° de convention de subvention: 742390

DOI

10.3030/742390

Projet clôturé

Date de signature de la CE 24 Août 2017

Date de début 1 Septembre 2017

Date de fin 31 Août 2023

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 2 355 000,00

Contribution de l’UE

€ 2 355 000,00

Coordonné par

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Publications

Peer reviewed articles (21)

Transcriptomic and proteomic profiling reveals distinct pathogenic features of peripheral non-classical monocytes in systemic lupus erythematosus

Auteurs: Eirini Maria Stergioti, Theodora Manolakou, George Sentis, Martina Samiotaki, Noemin Kapsala, Antonis Fanouriakis, Dimitrios T Boumpas, Aggelos Banos
Publié dans: Clinical Immunology, 2023, ISSN 2475-6296
Éditeur: ELSEVIER
DOI: 10.1016/j.clim.2023.109765

Microglia activation in the presence of intact blood-brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric lupus

Auteurs: Dionysis Nikolopoulos, Theodora Manolakou, Alexia Polissidis, Anastasia Filia, George Bertsias, Yassemi Koutmani, Dimitrios T Boumpas
Publié dans: Annals Rheumatic Dis, 2023, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/ard-2022-223506

Lupus or not? SLE Risk Probability Index (SLERPI): a simple, clinician-friendly machine learning-based model to assist the diagnosis of systemic lupus erythematosus

Auteurs: Christina Adamichou, Irini Genitsaridi, Dionysis Nikolopoulos, Myrto Nikoloudaki, Argyro Repa, Alessandra Bortoluzzi, Antonis Fanouriakis, Prodromos Sidiropoulos, Dimitrios T Boumpas, George K Bertsias
Publié dans: Annals of the Rheumatic Diseases, 2021, Page(s) annrheumdis-2020-219069, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-219069

Molecular Taxonomy of Systemic Lupus Erythematosus Through Data-Driven Patient Stratification: Molecular Endotypes and Cluster-Tailored Drugs

Auteurs: Panagiotis Garantziotis, Dimitrios Nikolakis, Stavros Doumas, Eleni Frangou, George Sentis, Anastasia Filia, Antonis Fanouriakis, George Bertsias, and Dimitrios T. Boumpas
Publié dans: Front Immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2022.860726

Combined – whole blood and skin fibroblasts- transcriptomic analysis in Psoriatic Arthritis reveals molecular signatures of activity, resistance and early response to treatment

Auteurs: Alexandros Grivas, Maria Grigoriou, Nikos Malissovas, George Sentis, Anastasia Filia, Sofia Flouda, Pelagia Katsimpri, Panayotis Verginis and Dimitrios T. Boumpas
Publié dans: Frontiers in Immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2022.964274

Enhanced and stabilized mesenchymal stem cell growth inside plasma pre-treated and collagen-coated PDMS-based microfluidic chambers

Auteurs: Dionysia Kefallinou, Maria Grigoriou, Vassilios Constantoudis, Ioannis Raptis, Evangelia Xenogiannopoulou, Athanasios Dimoulas, Dimitrios T. Boumpas, Angeliki Tserepi
Publié dans: Surface and Coatings Technology, 2023, ISSN 1879-3347
Éditeur: ELSEVIER
DOI: 10.1016/j.surfcoat.2023.129658

ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus

Auteurs: Theodora Manolakou, Dionysis Nikolopoulos, Dimitrios Gkikas, Anastasia Filia, Martina Samiotaki, George Stamatakis, Antonis Fanouriakis, Panagiotis Politis, Aggelos Banos, Themis Alissafi, Panayotis Verginis, Dimitrios T. Boumpas
Publié dans: SCIENCE ADVANCES, Numéro 23752548, 2022, ISSN 2375-2548
Éditeur: SCIENCE
DOI: 10.1126/sciadv.abo5840

Fabrication of a 3D microfluidic cell culture device for bone marrow-on-a-chip

Auteurs: Dionysia Kefallinou, Maria Grigoriou, Dimitrios T. Boumpas, Evangelos Gogolides, Angeliki Tserepi
Publié dans: Micro and Nano Engineering, Numéro 9, 2020, Page(s) 100075, ISSN 2590-0072
Éditeur: ELSEVIER
DOI: 10.1016/j.mne.2020.100075

Sexual dimorphism in SLE: above and beyond sex hormones

Auteurs: E.A.A. Christou, A. Banos, D. Kosmara, GK Bertsias, DT Boumpas
Publié dans: Lupus, Numéro 28/1, 2018, Page(s) 3-10, ISSN 0961-2033
Éditeur: SAGE Publications
DOI: 10.1177/0961203318815768

REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)

Auteurs: Eleni Frangou, Akrivi Chrysanthopoulou, Alexandros Mitsios, Konstantinos Kambas, Stella Arelaki, Iliana Angelidou, Athanasios Arampatzioglou, Hariklia Gakiopoulou, George K Bertsias, Panayotis Verginis, Konstantinos Ritis, Dimitrios T Boumpas
Publié dans: Annals of the Rheumatic Diseases, 2018, Page(s) annrheumdis-2018-213181, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-213181

IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

Auteurs: Katerina Gkirtzimanaki, Eleni Kabrani, Dimitra Nikoleri, Alexander Polyzos, Athanasios Blanas, Prodromos Sidiropoulos, Antonis Makrigiannakis, George Bertsias, Dimitrios T. Boumpas, Panayotis Verginis
Publié dans: Cell Reports, Numéro 25/4, 2018, Page(s) 921-933.e5, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2018.09.001

Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus

Auteurs: Maria Grigoriou, Aggelos Banos, Anastasia Filia, Pavlos Pavlidis, Stavroula Giannouli, Vassiliki Karali, Dionysis Nikolopoulos, Antigone Pieta, George Bertsias, Panayotis Verginis, Ioannis Mitroulis, Dimitrios T Boumpas
Publié dans: Annals of the Rheumatic Diseases, 2019, Page(s) annrheumdis-2019-215782, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-215782

Evolving phenotype of systemic lupus erythematosus in Caucasians: low incidence of lupus nephritis, high burden of neuropsychiatric disease and increased rates of late-onset lupus in the ‘Attikon’ cohort

Auteurs: D Nikolopoulos, M Kostopoulou, A Pieta, T Karageorgas, D Tseronis, K Chavatza, S Flouda, P Rapsomaniki, A Banos, E Kremasmenou, V Tzavara, P Katsimbri, A Fanouriakis, D T Boumpas
Publié dans: Lupus, 2020, Page(s) 096120332090893, ISSN 0961-2033
Éditeur: SAGE Publications
DOI: 10.1177/0961203320908932

Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity

Auteurs: Nikolaos I Panousis, George K Bertsias, Halit Ongen, Irini Gergianaki, Maria G Tektonidou, Maria Trachana, Luciana Romano-Palumbo, Deborah Bielser, Cedric Howald, Cristina Pamfil, Antonis Fanouriakis, Despoina Kosmara, Argyro Repa, Prodromos Sidiropoulos, Emmanouil T Dermitzakis, Dimitrios T Boumpas
Publié dans: Annals of the Rheumatic Diseases, Numéro 78/8, 2019, Page(s) 1079-1089, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-214379

Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity

Auteurs: Themis Alissafi, Lydia Kalafati, Maria Lazari, Anastasia Filia, Ismini Kloukina, Maria Manifava, Jong-Hyung Lim, Vasileia Ismini Alexaki, Nicholas T. Ktistakis, Triantafyllos Doskas, George A. Garinis, Triantafyllos Chavakis, Dimitrios T. Boumpas, Panayotis Verginis
Publié dans: Cell Metabolism, Numéro Online ahead of print, 2020, Page(s) Online ahead of print, ISSN 1550-4131
Éditeur: Cell Press
DOI: 10.1016/j.cmet.2020.07.001

Quality indicators for systemic lupus erythematosus based on the 2019 EULAR recommendations: development and initial validation in a cohort of 220 patients

Auteurs: Katerina Chavatza, Myrto Kostopoulou, Dionysis Nikolopoulos, Ourania Gioti, Konstantina Togia, Laura Andreoli, Martin Aringer, John Boletis, Andrea Doria, Frederic A Houssiau, David Jayne, Marta Mosca, Elisabet Svenungsson , Angela Tincani, George Bertsias, Antonis Fanouriakis, Dimitrios T Boumpas
Publié dans: Annals Rheumatic Disease, 2021, ISSN 0003-4967
Éditeur: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220438

The genomic landscape of ANCA-associated vasculitis: Distinct transcriptional signatures, molecular endotypes and comparison with systemic lupus erythematosus

Auteurs: Aggelos Banos, Konstantinos Thomas, Panagiotis Garantziotis, Anastasia Filia, Nikolaos Malissovas, Antigone Pieta, Dimitrios Nikolakis, Alexandros G Panagiotopoulos, Aglaia Chalkia, Dimitrios Petras, George Bertsias, Dimitrios T Boumpas, Dimitrios Vassilopoulos
Publié dans: Frontiers Immunology, 2023, ISSN 1664-3224
Éditeur: Frontiers in Immunology
DOI: 10.3389/fimmu.2023.1072598

Patrolling human SLE haematopoietic progenitors demonstrate enhanced extramedullary colonisation; implications for peripheral tissue injury

Auteurs: Ioannis Kokkinopoulos, Aggelos Banos, Maria Grigoriou, Anastasia Filia, Theodora Manolakou, Themis Alissafi, Nikolaos Malissovas, Ioannis Mitroulis, Panayotis Verginis, Dimitrios T Boumpas
Publié dans: Scientific Reports, 2021, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-95224-y

A network-based approach reveals long non-coding RNAs associated with disease activity in lupus nephritis: key pathways for flare and potential biomarkers to be used as liquid biopsies

Auteurs: George Sentis, Catherine Loukogiannaki, Nikos Malissovas, Dionysis Nikolopoulos,Theodora Manolakou, Sofia Flouda, Maria Grigoriou, Aggelos Banos, Dimitrios T. Boumpas,Anastasia Filia
Publié dans: Frontiers Immunology, 2023, ISSN 1664-3224
Éditeur: Frontiers Immunology
DOI: 10.3389/fimmu.2023.1203848

Enhanced medullary and extramedullary granulopoiesis sustain the inflammatory response in lupus nephritis

Auteurs: Eleni Zervopoulou, Maria Grigoriou, Stavros A Doumas, Danae Yiannakou, Pavlos Pavlidis, Gilles Gasparoni, Jörn Walter, Anastasia Filia, Harikleia Gakiopoulou, Aggelos Banos, Ioannis Mitroulis, Dimitrios T Boumpas
Publié dans: LUPUS SCIENCE AND MEDICINE, 2024, ISSN 2053-8790
Éditeur: BMJ
DOI: 10.1136/lupus-2023-001110

NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFN-α production in patients with SLE

Auteurs: Spiros Georgakis, Katerina Gkirtzimanaki, Garyfalia Papadaki, Hariklia Gakiopoulou, Elias Drakos, Maija-Leena Eloranta, Manousos Makridakis, Georgia Kontostathi, Jerome Zoidakis, Eirini Baira, Lars Rönnblom, Dimitrios T. Boumpas, Prodromos Sidiropoulos, Panayotis Verginis, and George Bertsias
Publié dans: JCI insight, Numéro 2021;6(21):e147671, 2021, ISSN 2379-3708
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.147671

Thesis and dissertations (1)

RNA-sequencing and transcriptome analysis of hematopoietic stem cells in systemic lupus erythematosus

Auteurs: Grigoriou Maria
Publié dans: 2019
Éditeur: Medical School of Athens