PRECISION CARE IN SYSTEMIC AUTOIMMUNITY: AN INTEGRATED MULTI-TISSUE/LEVEL APPROACH FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

Informazioni relative al progetto

LUPUSCARE

ID dell’accordo di sovvenzione: 742390

DOI

10.3030/742390

Progetto chiuso

Data della firma CE 24 Agosto 2017

Data di avvio 1 Settembre 2017

Data di completamento 31 Agosto 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 355 000,00

Contributo UE

€ 2 355 000,00

Coordinato da

IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (21)

Transcriptomic and proteomic profiling reveals distinct pathogenic features of peripheral non-classical monocytes in systemic lupus erythematosus

Autori: Eirini Maria Stergioti, Theodora Manolakou, George Sentis, Martina Samiotaki, Noemin Kapsala, Antonis Fanouriakis, Dimitrios T Boumpas, Aggelos Banos
Pubblicato in: Clinical Immunology, 2023, ISSN 2475-6296
Editore: ELSEVIER
DOI: 10.1016/j.clim.2023.109765

Microglia activation in the presence of intact blood-brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric lupus

Autori: Dionysis Nikolopoulos, Theodora Manolakou, Alexia Polissidis, Anastasia Filia, George Bertsias, Yassemi Koutmani, Dimitrios T Boumpas
Pubblicato in: Annals Rheumatic Dis, 2023, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/ard-2022-223506

Lupus or not? SLE Risk Probability Index (SLERPI): a simple, clinician-friendly machine learning-based model to assist the diagnosis of systemic lupus erythematosus

Autori: Christina Adamichou, Irini Genitsaridi, Dionysis Nikolopoulos, Myrto Nikoloudaki, Argyro Repa, Alessandra Bortoluzzi, Antonis Fanouriakis, Prodromos Sidiropoulos, Dimitrios T Boumpas, George K Bertsias
Pubblicato in: Annals of the Rheumatic Diseases, 2021, Pagina/e annrheumdis-2020-219069, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2020-219069

Molecular Taxonomy of Systemic Lupus Erythematosus Through Data-Driven Patient Stratification: Molecular Endotypes and Cluster-Tailored Drugs

Autori: Panagiotis Garantziotis, Dimitrios Nikolakis, Stavros Doumas, Eleni Frangou, George Sentis, Anastasia Filia, Antonis Fanouriakis, George Bertsias, and Dimitrios T. Boumpas
Pubblicato in: Front Immunology, 2022, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2022.860726

Combined – whole blood and skin fibroblasts- transcriptomic analysis in Psoriatic Arthritis reveals molecular signatures of activity, resistance and early response to treatment

Autori: Alexandros Grivas, Maria Grigoriou, Nikos Malissovas, George Sentis, Anastasia Filia, Sofia Flouda, Pelagia Katsimpri, Panayotis Verginis and Dimitrios T. Boumpas
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2022.964274

Enhanced and stabilized mesenchymal stem cell growth inside plasma pre-treated and collagen-coated PDMS-based microfluidic chambers

Autori: Dionysia Kefallinou, Maria Grigoriou, Vassilios Constantoudis, Ioannis Raptis, Evangelia Xenogiannopoulou, Athanasios Dimoulas, Dimitrios T. Boumpas, Angeliki Tserepi
Pubblicato in: Surface and Coatings Technology, 2023, ISSN 1879-3347
Editore: ELSEVIER
DOI: 10.1016/j.surfcoat.2023.129658

ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus

Autori: Theodora Manolakou, Dionysis Nikolopoulos, Dimitrios Gkikas, Anastasia Filia, Martina Samiotaki, George Stamatakis, Antonis Fanouriakis, Panagiotis Politis, Aggelos Banos, Themis Alissafi, Panayotis Verginis, Dimitrios T. Boumpas
Pubblicato in: SCIENCE ADVANCES, Numero 23752548, 2022, ISSN 2375-2548
Editore: SCIENCE
DOI: 10.1126/sciadv.abo5840

Fabrication of a 3D microfluidic cell culture device for bone marrow-on-a-chip

Autori: Dionysia Kefallinou, Maria Grigoriou, Dimitrios T. Boumpas, Evangelos Gogolides, Angeliki Tserepi
Pubblicato in: Micro and Nano Engineering, Numero 9, 2020, Pagina/e 100075, ISSN 2590-0072
Editore: ELSEVIER
DOI: 10.1016/j.mne.2020.100075

Sexual dimorphism in SLE: above and beyond sex hormones

Autori: E.A.A. Christou, A. Banos, D. Kosmara, GK Bertsias, DT Boumpas
Pubblicato in: Lupus, Numero 28/1, 2018, Pagina/e 3-10, ISSN 0961-2033
Editore: SAGE Publications
DOI: 10.1177/0961203318815768

REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)

Autori: Eleni Frangou, Akrivi Chrysanthopoulou, Alexandros Mitsios, Konstantinos Kambas, Stella Arelaki, Iliana Angelidou, Athanasios Arampatzioglou, Hariklia Gakiopoulou, George K Bertsias, Panayotis Verginis, Konstantinos Ritis, Dimitrios T Boumpas
Pubblicato in: Annals of the Rheumatic Diseases, 2018, Pagina/e annrheumdis-2018-213181, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-213181

IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

Autori: Katerina Gkirtzimanaki, Eleni Kabrani, Dimitra Nikoleri, Alexander Polyzos, Athanasios Blanas, Prodromos Sidiropoulos, Antonis Makrigiannakis, George Bertsias, Dimitrios T. Boumpas, Panayotis Verginis
Pubblicato in: Cell Reports, Numero 25/4, 2018, Pagina/e 921-933.e5, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.09.001

Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus

Autori: Maria Grigoriou, Aggelos Banos, Anastasia Filia, Pavlos Pavlidis, Stavroula Giannouli, Vassiliki Karali, Dionysis Nikolopoulos, Antigone Pieta, George Bertsias, Panayotis Verginis, Ioannis Mitroulis, Dimitrios T Boumpas
Pubblicato in: Annals of the Rheumatic Diseases, 2019, Pagina/e annrheumdis-2019-215782, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-215782

Evolving phenotype of systemic lupus erythematosus in Caucasians: low incidence of lupus nephritis, high burden of neuropsychiatric disease and increased rates of late-onset lupus in the ‘Attikon’ cohort

Autori: D Nikolopoulos, M Kostopoulou, A Pieta, T Karageorgas, D Tseronis, K Chavatza, S Flouda, P Rapsomaniki, A Banos, E Kremasmenou, V Tzavara, P Katsimbri, A Fanouriakis, D T Boumpas
Pubblicato in: Lupus, 2020, Pagina/e 096120332090893, ISSN 0961-2033
Editore: SAGE Publications
DOI: 10.1177/0961203320908932

Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity

Autori: Nikolaos I Panousis, George K Bertsias, Halit Ongen, Irini Gergianaki, Maria G Tektonidou, Maria Trachana, Luciana Romano-Palumbo, Deborah Bielser, Cedric Howald, Cristina Pamfil, Antonis Fanouriakis, Despoina Kosmara, Argyro Repa, Prodromos Sidiropoulos, Emmanouil T Dermitzakis, Dimitrios T Boumpas
Pubblicato in: Annals of the Rheumatic Diseases, Numero 78/8, 2019, Pagina/e 1079-1089, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-214379

Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity

Autori: Themis Alissafi, Lydia Kalafati, Maria Lazari, Anastasia Filia, Ismini Kloukina, Maria Manifava, Jong-Hyung Lim, Vasileia Ismini Alexaki, Nicholas T. Ktistakis, Triantafyllos Doskas, George A. Garinis, Triantafyllos Chavakis, Dimitrios T. Boumpas, Panayotis Verginis
Pubblicato in: Cell Metabolism, Numero Online ahead of print, 2020, Pagina/e Online ahead of print, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2020.07.001

Quality indicators for systemic lupus erythematosus based on the 2019 EULAR recommendations: development and initial validation in a cohort of 220 patients

Autori: Katerina Chavatza, Myrto Kostopoulou, Dionysis Nikolopoulos, Ourania Gioti, Konstantina Togia, Laura Andreoli, Martin Aringer, John Boletis, Andrea Doria, Frederic A Houssiau, David Jayne, Marta Mosca, Elisabet Svenungsson , Angela Tincani, George Bertsias, Antonis Fanouriakis, Dimitrios T Boumpas
Pubblicato in: Annals Rheumatic Disease, 2021, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220438

The genomic landscape of ANCA-associated vasculitis: Distinct transcriptional signatures, molecular endotypes and comparison with systemic lupus erythematosus

Autori: Aggelos Banos, Konstantinos Thomas, Panagiotis Garantziotis, Anastasia Filia, Nikolaos Malissovas, Antigone Pieta, Dimitrios Nikolakis, Alexandros G Panagiotopoulos, Aglaia Chalkia, Dimitrios Petras, George Bertsias, Dimitrios T Boumpas, Dimitrios Vassilopoulos
Pubblicato in: Frontiers Immunology, 2023, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2023.1072598

Patrolling human SLE haematopoietic progenitors demonstrate enhanced extramedullary colonisation; implications for peripheral tissue injury

Autori: Ioannis Kokkinopoulos, Aggelos Banos, Maria Grigoriou, Anastasia Filia, Theodora Manolakou, Themis Alissafi, Nikolaos Malissovas, Ioannis Mitroulis, Panayotis Verginis, Dimitrios T Boumpas
Pubblicato in: Scientific Reports, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-95224-y

A network-based approach reveals long non-coding RNAs associated with disease activity in lupus nephritis: key pathways for flare and potential biomarkers to be used as liquid biopsies

Autori: George Sentis, Catherine Loukogiannaki, Nikos Malissovas, Dionysis Nikolopoulos,Theodora Manolakou, Sofia Flouda, Maria Grigoriou, Aggelos Banos, Dimitrios T. Boumpas,Anastasia Filia
Pubblicato in: Frontiers Immunology, 2023, ISSN 1664-3224
Editore: Frontiers Immunology
DOI: 10.3389/fimmu.2023.1203848

Enhanced medullary and extramedullary granulopoiesis sustain the inflammatory response in lupus nephritis

Autori: Eleni Zervopoulou, Maria Grigoriou, Stavros A Doumas, Danae Yiannakou, Pavlos Pavlidis, Gilles Gasparoni, Jörn Walter, Anastasia Filia, Harikleia Gakiopoulou, Aggelos Banos, Ioannis Mitroulis, Dimitrios T Boumpas
Pubblicato in: LUPUS SCIENCE AND MEDICINE, 2024, ISSN 2053-8790
Editore: BMJ
DOI: 10.1136/lupus-2023-001110

NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFN-α production in patients with SLE

Autori: Spiros Georgakis, Katerina Gkirtzimanaki, Garyfalia Papadaki, Hariklia Gakiopoulou, Elias Drakos, Maija-Leena Eloranta, Manousos Makridakis, Georgia Kontostathi, Jerome Zoidakis, Eirini Baira, Lars Rönnblom, Dimitrios T. Boumpas, Prodromos Sidiropoulos, Panayotis Verginis, and George Bertsias
Pubblicato in: JCI insight, Numero 2021;6(21):e147671, 2021, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.147671

Thesis and dissertations (1)

RNA-sequencing and transcriptome analysis of hematopoietic stem cells in systemic lupus erythematosus

Autori: Grigoriou Maria
Pubblicato in: 2019
Editore: Medical School of Athens