DNA Damage and Repair and its Impact on Healthy Ageing

Project Information

Dam2Age

Grant agreement ID: 742426

DOI 10.3030/742426

Project closed

EC signature date 24 August 2017

Start date 1 September 2017

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 251 719,00

EU contribution € 2 251 719,00

Coordinated by

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

Publications

Peer reviewed articles (21)

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

Author(s): Chiara Milanese, Cíntia R. Bombardieri, Sara Sepe, Sander Barnhoorn, César Payán-Goméz, Donatella Caruso, Matteo Audano, Silvia Pedretti, Wilbert P. Vermeij, Renata M. C. Brandt, Akos Gyenis, Mirjam M. Wamelink, Annelieke S. de Wit, Roel C. Janssens, René Leen, André B. P. van Kuilenburg, Nico Mitro, Jan H. J. Hoeijmakers, Pier G. Mastroberardino
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12640-5

Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin

Author(s): Dong Eun Kim, Martijn E. T. Dollé, Wilbert P. Vermeij, Akos Gyenis, Katharina Vogel, Jan H. J. Hoeijmakers, Christopher D. Wiley, Albert R. Davalos, Paul Hasty, Pierre‐Yves Desprez, Judith Campisi
Published in: Aging Cell, Issue 19/3, 2020, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13072

Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

Author(s): Paula K. Bautista-Niño, Eliana Portilla-Fernandez, Eloisa Rubio-Beltrán, Janette J. van der Linden, René de Vries, Richard van Veghel, Martine de Boer, Matej Durik, Yanto Ridwan, Renata Brandt, Jeroen Essers, Robert I. Menzies, Rachel Thomas, Alain de Bruin, Dirk J. Duncker, Heleen M.M. van Beusekom, Mohsen Ghanbari, Jan H.J. Hoeijmakers, Radislav Sedlacek, Rhian M. Touyz, Augusto C. Mo
Published in: Clinical Science, Issue 134/7, 2020, Page(s) 727-746, ISSN 0143-5221
Publisher: Portland Press, Ltd.
DOI: 10.1042/cs20190124

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer

Author(s): Myrthe Jager, Francis Blokzijl, Ewart Kuijk, Johanna Bertl, Maria Vougioukalaki, Roel Janssen, Nicolle Besselink, Sander Boymans, Joep de Ligt, Jakob Skou Pedersen, Jan Hoeijmakers, Joris Pothof, Ruben van Boxtel, Edwin Cuppen
Published in: Genome Research, Issue 29/7, 2019, Page(s) 1067-1077, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.246223.118

Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients

Author(s): Franny Jongbloed, Ron W.F. de Bruin, Harry Van Steeg, Piet Beekhof, Paul Wackers, Dennis A. Hesselink, Jan H.J. Hoeijmakers, Martijn E.T. Dollé, Jan N.M. IJzermans
Published in: Aging, Issue 12/13, 2020, Page(s) 12441-12467, ISSN 1945-4589
Publisher: Aging
DOI: 10.18632/aging.103619

A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction

Author(s): F. Jongbloed, T. C. Saat, M. Verweij, C. Payan-Gomez, J. H. J. Hoeijmakers, S. van den Engel, C. T. van Oostrom, G. Ambagtsheer, S. Imholz, J. L. A. Pennings, H. van Steeg, J. N. M. IJzermans, M. E. T. Dollé, R. W. F. de Bruin
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep40901

DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway

Author(s): I. K. Mandemaker, L. van Cuijk, R. C. Janssens, H. Lans, K. Bezstarosti, J. H. Hoeijmakers, J. A. Demmers, W. Vermeulen, J. A. Marteijn
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-15194-y

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1

Author(s): Cristina Ribeiro-Silva, Özge Z. Aydin, Raquel Mesquita-Ribeiro, Jana Slyskova, Angela Helfricht, Jurgen A. Marteijn, Jan H. J. Hoeijmakers, Hannes Lans, Wim Vermeulen
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06402-y

Increased brain-predicted aging in treated HIV disease

Author(s): James H. Cole, Jonathan Underwood, Matthan W.A. Caan, Davide De Francesco, Rosan A. van Zoest, Robert Leech, Ferdinand W.N.M. Wit, Peter Portegies, Gert J. Geurtsen, Ben A. Schmand, Maarten F. Schim van der Loeff, Claudio Franceschi, Caroline A. Sabin, Charles B.L.M. Majoie, Alan Winston, Peter Reiss, David J. Sharp
Published in: Neurology, Issue 88/14, 2017, Page(s) 1349-1357, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000003790

Cellular senescence drives age-dependent hepatic steatosis

Author(s): Mikolaj Ogrodnik, Satomi Miwa, Tamar Tchkonia, Dina Tiniakos, Caroline L. Wilson, Albert Lahat, Christoper P. Day, Alastair Burt, Allyson Palmer, Quentin M. Anstee, Sushma Nagaraja Grellscheid, Jan H J. Hoeijmakers, Sander Barnhoorn, Derek A. Mann, Thomas G. Bird, Wilbert P. Vermeij, James L. Kirkland, João F. Passos, Thomas von Zglinicki, Diana Jurk
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms15691

After surviving cancer, what about late life effects of the cure?

Author(s): Julie Nonnekens, Jan HJ Hoeijmakers
Published in: EMBO Molecular Medicine, Issue 9/1, 2016, Page(s) 4-6, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201607062

DNA damage‐induced replication stress results in PA 200‐proteasome‐mediated degradation of acetylated histones

Author(s): Imke K Mandemaker, Marit E Geijer, Iris Kik, Karel Bezstarosti, Erikjan Rijkers, Anja Raams, Roel C Janssens, Hannes Lans, Jan HJ Hoeijmakers, Jeroen AA Demmers, Wim Vermeulen, Jurgen A Marteijn
Published in: EMBO reports, Issue 19/10, 2018, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201745566

Trichothiodystrophy causative TFIIEβ mutation affects transcription in highly differentiated tissue

Author(s): Arjan F Theil, Imke K Mandemaker, Emile van den Akker, Sigrid M A Swagemakers, Anja Raams, Tatjana Wüst, Jurgen A Marteijn, Jacques C Giltay, Richard M Colombijn, Ute Moog, Urania Kotzaeridou, Mehrnaz Ghazvini, Marieke von Lindern, Jan H J Hoeijmakers, Nicolaas G J Jaspers, Peter J van der Spek, Wim Vermeulen
Published in: Human Molecular Genetics, Issue 26/23, 2017, Page(s) 4689-4698, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddx351

Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease

Author(s): Chiara Milanese, Silvia Cerri, Ayse Ulusoy, Simona V. Gornati, Audrey Plat, Sylvia Gabriels, Fabio Blandini, Donato A. Di Monte, Jan H. Hoeijmakers, Pier G. Mastroberardino
Published in: Cell Death & Disease, Issue 9/8, 2018, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-018-0848-7

The DNA damage response to transcription stress

Author(s): Hannes Lans, Jan H. J. Hoeijmakers, Wim Vermeulen, Jurgen A. Marteijn
Published in: Nature Reviews Molecular Cell Biology, Issue 20/12, 2019, Page(s) 766-784, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-019-0169-4

Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1 −/Δ7 mice

Author(s): Adriaan A. van Beek, Floor Hugenholtz, Ben Meijer, Bruno Sovran, Olaf Perdijk, Wilbert P. Vermeij, Renata M. C. Brandt, Sander Barnhoorn, Jan H. J. Hoeijmakers, Paul de Vos, Pieter J. M. Leenen, Rudi W. Hendriks, Huub F. J. Savelkoul
Published in: Journal of Leukocyte Biology, Issue 101/4, 2017, Page(s) 811-821, ISSN 0741-5400
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1189/jlb.1hi0216-062rr

Nuclear Genomic Instability and Aging

Author(s): Laura J. Niedernhofer, Aditi U. Gurkar, Yinsheng Wang, Jan Vijg, Jan H.J. Hoeijmakers, Paul D. Robbins
Published in: Annual Review of Biochemistry, Issue 87/1, 2018, Page(s) 295-322, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-062917-012239

Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

Author(s): Khalid Alyodawi, Wilbert P. Vermeij, Saleh Omairi, Oliver Kretz, Mark Hopkinson, Francesca Solagna, Barbara Joch, Renata M.C. Brandt, Sander Barnhoorn, Nicole Vliet, Yanto Ridwan, Jeroen Essers, Robert Mitchell, Taryn Morash, Arja Pasternack, Olli Ritvos, Antonios Matsakas, Henry Collins‐Hooper, Tobias B. Huber, Jan H.J. Hoeijmakers, Ketan Patel
Published in: Journal of Cachexia, Sarcopenia and Muscle, Issue 10/3, 2019, Page(s) 662-686, ISSN 2190-5991
Publisher: Springer Verlag
DOI: 10.1002/jcsm.12404

Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1Δ/− mice

Author(s): Haiyan Wu, Bibi S. van Thiel, Paula K. Bautista-Niño, Erwin Reiling, Matej Durik, Frank P.J. Leijten, Yanto Ridwan, Renata M.C. Brandt, Harry van Steeg, Martijn E.T. Dollé, Wilbert P. Vermeij, Jan H.J. Hoeijmakers, Jeroen Essers, Ingrid van der Pluijm, A.H. Jan Danser, Anton J.M. Roks
Published in: Clinical Science, Issue 131/15, 2017, Page(s) 1941-1953, ISSN 0143-5221
Publisher: Portland Press, Ltd.
DOI: 10.1042/cs20170026

Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype

Author(s): Arjan F. Theil, Elena Botta, Anja Raams, Desiree E.C. Smith, Marisa I. Mendes, Giuseppina Caligiuri, Sarah Giachetti, Silvia Bione, Roberta Carriero, Giordano Liberi, Luca Zardoni, Sigrid M.A. Swagemakers, Gajja S. Salomons, Alain Sarasin, Alan Lehmann, Peter J. van der Spek, Tomoo Ogi, Jan H.J. Hoeijmakers, Wim Vermeulen, Donata Orioli
Published in: The American Journal of Human Genetics, Issue 105/2, 2019, Page(s) 434-440, ISSN 0002-9297
Publisher: University of Chicago Press
DOI: 10.1016/j.ajhg.2019.06.017

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Author(s): Marjolein P. Baar, Renata M.C. Brandt, Diana A. Putavet, Julian D.D. Klein, Kasper W.J. Derks, Benjamin R.M. Bourgeois, Sarah Stryeck, Yvonne Rijksen, Hester van Willigenburg, Danny A. Feijtel, Ingrid van der Pluijm, Jeroen Essers, Wiggert A. van Cappellen, Wilfred F. van IJcken, Adriaan B. Houtsmuller, Joris Pothof, Ron W.F. de Bruin, Tobias Madl, Jan H.J. Hoeijmakers, Judith Campisi, Peter L.J.
Published in: Cell, Issue 169/1, 2017, Page(s) 132-147.e16, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.02.031