DNA Damage and Repair and its Impact on Healthy Ageing

Informazioni relative al progetto

Dam2Age

ID dell’accordo di sovvenzione: 742426

DOI

10.3030/742426

Progetto chiuso

Data della firma CE 24 Agosto 2017

Data di avvio 1 Settembre 2017

Data di completamento 31 Agosto 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 251 719,00

Contributo UE

€ 2 251 719,00

Coordinato da

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (21)

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

Autori: Chiara Milanese, Cíntia R. Bombardieri, Sara Sepe, Sander Barnhoorn, César Payán-Goméz, Donatella Caruso, Matteo Audano, Silvia Pedretti, Wilbert P. Vermeij, Renata M. C. Brandt, Akos Gyenis, Mirjam M. Wamelink, Annelieke S. de Wit, Roel C. Janssens, René Leen, André B. P. van Kuilenburg, Nico Mitro, Jan H. J. Hoeijmakers, Pier G. Mastroberardino
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-12640-5

Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin

Autori: Dong Eun Kim, Martijn E. T. Dollé, Wilbert P. Vermeij, Akos Gyenis, Katharina Vogel, Jan H. J. Hoeijmakers, Christopher D. Wiley, Albert R. Davalos, Paul Hasty, Pierre‐Yves Desprez, Judith Campisi
Pubblicato in: Aging Cell, Numero 19/3, 2020, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.13072

Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

Autori: Paula K. Bautista-Niño, Eliana Portilla-Fernandez, Eloisa Rubio-Beltrán, Janette J. van der Linden, René de Vries, Richard van Veghel, Martine de Boer, Matej Durik, Yanto Ridwan, Renata Brandt, Jeroen Essers, Robert I. Menzies, Rachel Thomas, Alain de Bruin, Dirk J. Duncker, Heleen M.M. van Beusekom, Mohsen Ghanbari, Jan H.J. Hoeijmakers, Radislav Sedlacek, Rhian M. Touyz, Augusto C. Mo
Pubblicato in: Clinical Science, Numero 134/7, 2020, Pagina/e 727-746, ISSN 0143-5221
Editore: Portland Press, Ltd.
DOI: 10.1042/cs20190124

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer

Autori: Myrthe Jager, Francis Blokzijl, Ewart Kuijk, Johanna Bertl, Maria Vougioukalaki, Roel Janssen, Nicolle Besselink, Sander Boymans, Joep de Ligt, Jakob Skou Pedersen, Jan Hoeijmakers, Joris Pothof, Ruben van Boxtel, Edwin Cuppen
Pubblicato in: Genome Research, Numero 29/7, 2019, Pagina/e 1067-1077, ISSN 1088-9051
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.246223.118

Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients

Autori: Franny Jongbloed, Ron W.F. de Bruin, Harry Van Steeg, Piet Beekhof, Paul Wackers, Dennis A. Hesselink, Jan H.J. Hoeijmakers, Martijn E.T. Dollé, Jan N.M. IJzermans
Pubblicato in: Aging, Numero 12/13, 2020, Pagina/e 12441-12467, ISSN 1945-4589
Editore: Aging
DOI: 10.18632/aging.103619

A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction

Autori: F. Jongbloed, T. C. Saat, M. Verweij, C. Payan-Gomez, J. H. J. Hoeijmakers, S. van den Engel, C. T. van Oostrom, G. Ambagtsheer, S. Imholz, J. L. A. Pennings, H. van Steeg, J. N. M. IJzermans, M. E. T. Dollé, R. W. F. de Bruin
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep40901

DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway

Autori: I. K. Mandemaker, L. van Cuijk, R. C. Janssens, H. Lans, K. Bezstarosti, J. H. Hoeijmakers, J. A. Demmers, W. Vermeulen, J. A. Marteijn
Pubblicato in: Scientific Reports, Numero 7/1, 2017, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-017-15194-y

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1

Autori: Cristina Ribeiro-Silva, Özge Z. Aydin, Raquel Mesquita-Ribeiro, Jana Slyskova, Angela Helfricht, Jurgen A. Marteijn, Jan H. J. Hoeijmakers, Hannes Lans, Wim Vermeulen
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-06402-y

Increased brain-predicted aging in treated HIV disease

Autori: James H. Cole, Jonathan Underwood, Matthan W.A. Caan, Davide De Francesco, Rosan A. van Zoest, Robert Leech, Ferdinand W.N.M. Wit, Peter Portegies, Gert J. Geurtsen, Ben A. Schmand, Maarten F. Schim van der Loeff, Claudio Franceschi, Caroline A. Sabin, Charles B.L.M. Majoie, Alan Winston, Peter Reiss, David J. Sharp
Pubblicato in: Neurology, Numero 88/14, 2017, Pagina/e 1349-1357, ISSN 0028-3878
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000003790

Cellular senescence drives age-dependent hepatic steatosis

Autori: Mikolaj Ogrodnik, Satomi Miwa, Tamar Tchkonia, Dina Tiniakos, Caroline L. Wilson, Albert Lahat, Christoper P. Day, Alastair Burt, Allyson Palmer, Quentin M. Anstee, Sushma Nagaraja Grellscheid, Jan H J. Hoeijmakers, Sander Barnhoorn, Derek A. Mann, Thomas G. Bird, Wilbert P. Vermeij, James L. Kirkland, João F. Passos, Thomas von Zglinicki, Diana Jurk
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms15691

After surviving cancer, what about late life effects of the cure?

Autori: Julie Nonnekens, Jan HJ Hoeijmakers
Pubblicato in: EMBO Molecular Medicine, Numero 9/1, 2016, Pagina/e 4-6, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201607062

DNA damage‐induced replication stress results in PA 200‐proteasome‐mediated degradation of acetylated histones

Autori: Imke K Mandemaker, Marit E Geijer, Iris Kik, Karel Bezstarosti, Erikjan Rijkers, Anja Raams, Roel C Janssens, Hannes Lans, Jan HJ Hoeijmakers, Jeroen AA Demmers, Wim Vermeulen, Jurgen A Marteijn
Pubblicato in: EMBO reports, Numero 19/10, 2018, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.201745566

Trichothiodystrophy causative TFIIEβ mutation affects transcription in highly differentiated tissue

Autori: Arjan F Theil, Imke K Mandemaker, Emile van den Akker, Sigrid M A Swagemakers, Anja Raams, Tatjana Wüst, Jurgen A Marteijn, Jacques C Giltay, Richard M Colombijn, Ute Moog, Urania Kotzaeridou, Mehrnaz Ghazvini, Marieke von Lindern, Jan H J Hoeijmakers, Nicolaas G J Jaspers, Peter J van der Spek, Wim Vermeulen
Pubblicato in: Human Molecular Genetics, Numero 26/23, 2017, Pagina/e 4689-4698, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddx351

Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease

Autori: Chiara Milanese, Silvia Cerri, Ayse Ulusoy, Simona V. Gornati, Audrey Plat, Sylvia Gabriels, Fabio Blandini, Donato A. Di Monte, Jan H. Hoeijmakers, Pier G. Mastroberardino
Pubblicato in: Cell Death & Disease, Numero 9/8, 2018, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-018-0848-7

The DNA damage response to transcription stress

Autori: Hannes Lans, Jan H. J. Hoeijmakers, Wim Vermeulen, Jurgen A. Marteijn
Pubblicato in: Nature Reviews Molecular Cell Biology, Numero 20/12, 2019, Pagina/e 766-784, ISSN 1471-0072
Editore: Nature Publishing Group
DOI: 10.1038/s41580-019-0169-4

Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1 −/Δ7 mice

Autori: Adriaan A. van Beek, Floor Hugenholtz, Ben Meijer, Bruno Sovran, Olaf Perdijk, Wilbert P. Vermeij, Renata M. C. Brandt, Sander Barnhoorn, Jan H. J. Hoeijmakers, Paul de Vos, Pieter J. M. Leenen, Rudi W. Hendriks, Huub F. J. Savelkoul
Pubblicato in: Journal of Leukocyte Biology, Numero 101/4, 2017, Pagina/e 811-821, ISSN 0741-5400
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1189/jlb.1hi0216-062rr

Nuclear Genomic Instability and Aging

Autori: Laura J. Niedernhofer, Aditi U. Gurkar, Yinsheng Wang, Jan Vijg, Jan H.J. Hoeijmakers, Paul D. Robbins
Pubblicato in: Annual Review of Biochemistry, Numero 87/1, 2018, Pagina/e 295-322, ISSN 0066-4154
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-062917-012239

Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

Autori: Khalid Alyodawi, Wilbert P. Vermeij, Saleh Omairi, Oliver Kretz, Mark Hopkinson, Francesca Solagna, Barbara Joch, Renata M.C. Brandt, Sander Barnhoorn, Nicole Vliet, Yanto Ridwan, Jeroen Essers, Robert Mitchell, Taryn Morash, Arja Pasternack, Olli Ritvos, Antonios Matsakas, Henry Collins‐Hooper, Tobias B. Huber, Jan H.J. Hoeijmakers, Ketan Patel
Pubblicato in: Journal of Cachexia, Sarcopenia and Muscle, Numero 10/3, 2019, Pagina/e 662-686, ISSN 2190-5991
Editore: Springer Verlag
DOI: 10.1002/jcsm.12404

Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1Δ/− mice

Autori: Haiyan Wu, Bibi S. van Thiel, Paula K. Bautista-Niño, Erwin Reiling, Matej Durik, Frank P.J. Leijten, Yanto Ridwan, Renata M.C. Brandt, Harry van Steeg, Martijn E.T. Dollé, Wilbert P. Vermeij, Jan H.J. Hoeijmakers, Jeroen Essers, Ingrid van der Pluijm, A.H. Jan Danser, Anton J.M. Roks
Pubblicato in: Clinical Science, Numero 131/15, 2017, Pagina/e 1941-1953, ISSN 0143-5221
Editore: Portland Press, Ltd.
DOI: 10.1042/cs20170026

Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype

Autori: Arjan F. Theil, Elena Botta, Anja Raams, Desiree E.C. Smith, Marisa I. Mendes, Giuseppina Caligiuri, Sarah Giachetti, Silvia Bione, Roberta Carriero, Giordano Liberi, Luca Zardoni, Sigrid M.A. Swagemakers, Gajja S. Salomons, Alain Sarasin, Alan Lehmann, Peter J. van der Spek, Tomoo Ogi, Jan H.J. Hoeijmakers, Wim Vermeulen, Donata Orioli
Pubblicato in: The American Journal of Human Genetics, Numero 105/2, 2019, Pagina/e 434-440, ISSN 0002-9297
Editore: University of Chicago Press
DOI: 10.1016/j.ajhg.2019.06.017

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Autori: Marjolein P. Baar, Renata M.C. Brandt, Diana A. Putavet, Julian D.D. Klein, Kasper W.J. Derks, Benjamin R.M. Bourgeois, Sarah Stryeck, Yvonne Rijksen, Hester van Willigenburg, Danny A. Feijtel, Ingrid van der Pluijm, Jeroen Essers, Wiggert A. van Cappellen, Wilfred F. van IJcken, Adriaan B. Houtsmuller, Joris Pothof, Ron W.F. de Bruin, Tobias Madl, Jan H.J. Hoeijmakers, Judith Campisi, Peter L.J.
Pubblicato in: Cell, Numero 169/1, 2017, Pagina/e 132-147.e16, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2017.02.031