DNA Damage and Repair and its Impact on Healthy Ageing

Publicaciones

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

Autores: Chiara Milanese, Cíntia R. Bombardieri, Sara Sepe, Sander Barnhoorn, César Payán-Goméz, Donatella Caruso, Matteo Audano, Silvia Pedretti, Wilbert P. Vermeij, Renata M. C. Brandt, Akos Gyenis, Mirjam M. Wamelink, Annelieke S. de Wit, Roel C. Janssens, René Leen, André B. P. van Kuilenburg, Nico Mitro, Jan H. J. Hoeijmakers, Pier G. Mastroberardino
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-12640-5

Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin

Autores: Dong Eun Kim, Martijn E. T. Dollé, Wilbert P. Vermeij, Akos Gyenis, Katharina Vogel, Jan H. J. Hoeijmakers, Christopher D. Wiley, Albert R. Davalos, Paul Hasty, Pierre‐Yves Desprez, Judith Campisi
Publicado en: Aging Cell, Edición 19/3, 2020, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.13072

Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

Autores: Paula K. Bautista-Niño, Eliana Portilla-Fernandez, Eloisa Rubio-Beltrán, Janette J. van der Linden, René de Vries, Richard van Veghel, Martine de Boer, Matej Durik, Yanto Ridwan, Renata Brandt, Jeroen Essers, Robert I. Menzies, Rachel Thomas, Alain de Bruin, Dirk J. Duncker, Heleen M.M. van Beusekom, Mohsen Ghanbari, Jan H.J. Hoeijmakers, Radislav Sedlacek, Rhian M. Touyz, Augusto C. Mo
Publicado en: Clinical Science, Edición 134/7, 2020, Página(s) 727-746, ISSN 0143-5221
Editor: Portland Press, Ltd.
DOI: 10.1042/cs20190124

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer

Autores: Myrthe Jager, Francis Blokzijl, Ewart Kuijk, Johanna Bertl, Maria Vougioukalaki, Roel Janssen, Nicolle Besselink, Sander Boymans, Joep de Ligt, Jakob Skou Pedersen, Jan Hoeijmakers, Joris Pothof, Ruben van Boxtel, Edwin Cuppen
Publicado en: Genome Research, Edición 29/7, 2019, Página(s) 1067-1077, ISSN 1088-9051
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.246223.118

Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients

Autores: Franny Jongbloed, Ron W.F. de Bruin, Harry Van Steeg, Piet Beekhof, Paul Wackers, Dennis A. Hesselink, Jan H.J. Hoeijmakers, Martijn E.T. Dollé, Jan N.M. IJzermans
Publicado en: Aging, Edición 12/13, 2020, Página(s) 12441-12467, ISSN 1945-4589
Editor: Aging
DOI: 10.18632/aging.103619

A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction

Autores: F. Jongbloed, T. C. Saat, M. Verweij, C. Payan-Gomez, J. H. J. Hoeijmakers, S. van den Engel, C. T. van Oostrom, G. Ambagtsheer, S. Imholz, J. L. A. Pennings, H. van Steeg, J. N. M. IJzermans, M. E. T. Dollé, R. W. F. de Bruin
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep40901

DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway

Autores: I. K. Mandemaker, L. van Cuijk, R. C. Janssens, H. Lans, K. Bezstarosti, J. H. Hoeijmakers, J. A. Demmers, W. Vermeulen, J. A. Marteijn
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-15194-y

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1

Autores: Cristina Ribeiro-Silva, Özge Z. Aydin, Raquel Mesquita-Ribeiro, Jana Slyskova, Angela Helfricht, Jurgen A. Marteijn, Jan H. J. Hoeijmakers, Hannes Lans, Wim Vermeulen
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-06402-y

Increased brain-predicted aging in treated HIV disease

Autores: James H. Cole, Jonathan Underwood, Matthan W.A. Caan, Davide De Francesco, Rosan A. van Zoest, Robert Leech, Ferdinand W.N.M. Wit, Peter Portegies, Gert J. Geurtsen, Ben A. Schmand, Maarten F. Schim van der Loeff, Claudio Franceschi, Caroline A. Sabin, Charles B.L.M. Majoie, Alan Winston, Peter Reiss, David J. Sharp
Publicado en: Neurology, Edición 88/14, 2017, Página(s) 1349-1357, ISSN 0028-3878
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000003790

Cellular senescence drives age-dependent hepatic steatosis

Autores: Mikolaj Ogrodnik, Satomi Miwa, Tamar Tchkonia, Dina Tiniakos, Caroline L. Wilson, Albert Lahat, Christoper P. Day, Alastair Burt, Allyson Palmer, Quentin M. Anstee, Sushma Nagaraja Grellscheid, Jan H J. Hoeijmakers, Sander Barnhoorn, Derek A. Mann, Thomas G. Bird, Wilbert P. Vermeij, James L. Kirkland, João F. Passos, Thomas von Zglinicki, Diana Jurk
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms15691

After surviving cancer, what about late life effects of the cure?

Autores: Julie Nonnekens, Jan HJ Hoeijmakers
Publicado en: EMBO Molecular Medicine, Edición 9/1, 2016, Página(s) 4-6, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201607062

DNA damage‐induced replication stress results in PA 200‐proteasome‐mediated degradation of acetylated histones

Autores: Imke K Mandemaker, Marit E Geijer, Iris Kik, Karel Bezstarosti, Erikjan Rijkers, Anja Raams, Roel C Janssens, Hannes Lans, Jan HJ Hoeijmakers, Jeroen AA Demmers, Wim Vermeulen, Jurgen A Marteijn
Publicado en: EMBO reports, Edición 19/10, 2018, ISSN 1469-221X
Editor: Nature Publishing Group
DOI: 10.15252/embr.201745566

Trichothiodystrophy causative TFIIEβ mutation affects transcription in highly differentiated tissue

Autores: Arjan F Theil, Imke K Mandemaker, Emile van den Akker, Sigrid M A Swagemakers, Anja Raams, Tatjana Wüst, Jurgen A Marteijn, Jacques C Giltay, Richard M Colombijn, Ute Moog, Urania Kotzaeridou, Mehrnaz Ghazvini, Marieke von Lindern, Jan H J Hoeijmakers, Nicolaas G J Jaspers, Peter J van der Spek, Wim Vermeulen
Publicado en: Human Molecular Genetics, Edición 26/23, 2017, Página(s) 4689-4698, ISSN 0964-6906
Editor: Oxford University Press
DOI: 10.1093/hmg/ddx351

Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease

Autores: Chiara Milanese, Silvia Cerri, Ayse Ulusoy, Simona V. Gornati, Audrey Plat, Sylvia Gabriels, Fabio Blandini, Donato A. Di Monte, Jan H. Hoeijmakers, Pier G. Mastroberardino
Publicado en: Cell Death & Disease, Edición 9/8, 2018, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-018-0848-7

The DNA damage response to transcription stress

Autores: Hannes Lans, Jan H. J. Hoeijmakers, Wim Vermeulen, Jurgen A. Marteijn
Publicado en: Nature Reviews Molecular Cell Biology, Edición 20/12, 2019, Página(s) 766-784, ISSN 1471-0072
Editor: Nature Publishing Group
DOI: 10.1038/s41580-019-0169-4

Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1 −/Δ7 mice

Autores: Adriaan A. van Beek, Floor Hugenholtz, Ben Meijer, Bruno Sovran, Olaf Perdijk, Wilbert P. Vermeij, Renata M. C. Brandt, Sander Barnhoorn, Jan H. J. Hoeijmakers, Paul de Vos, Pieter J. M. Leenen, Rudi W. Hendriks, Huub F. J. Savelkoul
Publicado en: Journal of Leukocyte Biology, Edición 101/4, 2017, Página(s) 811-821, ISSN 0741-5400
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1189/jlb.1hi0216-062rr

Nuclear Genomic Instability and Aging

Autores: Laura J. Niedernhofer, Aditi U. Gurkar, Yinsheng Wang, Jan Vijg, Jan H.J. Hoeijmakers, Paul D. Robbins
Publicado en: Annual Review of Biochemistry, Edición 87/1, 2018, Página(s) 295-322, ISSN 0066-4154
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-062917-012239

Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

Autores: Khalid Alyodawi, Wilbert P. Vermeij, Saleh Omairi, Oliver Kretz, Mark Hopkinson, Francesca Solagna, Barbara Joch, Renata M.C. Brandt, Sander Barnhoorn, Nicole Vliet, Yanto Ridwan, Jeroen Essers, Robert Mitchell, Taryn Morash, Arja Pasternack, Olli Ritvos, Antonios Matsakas, Henry Collins‐Hooper, Tobias B. Huber, Jan H.J. Hoeijmakers, Ketan Patel
Publicado en: Journal of Cachexia, Sarcopenia and Muscle, Edición 10/3, 2019, Página(s) 662-686, ISSN 2190-5991
Editor: Springer Verlag
DOI: 10.1002/jcsm.12404

Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1Δ/− mice

Autores: Haiyan Wu, Bibi S. van Thiel, Paula K. Bautista-Niño, Erwin Reiling, Matej Durik, Frank P.J. Leijten, Yanto Ridwan, Renata M.C. Brandt, Harry van Steeg, Martijn E.T. Dollé, Wilbert P. Vermeij, Jan H.J. Hoeijmakers, Jeroen Essers, Ingrid van der Pluijm, A.H. Jan Danser, Anton J.M. Roks
Publicado en: Clinical Science, Edición 131/15, 2017, Página(s) 1941-1953, ISSN 0143-5221
Editor: Portland Press, Ltd.
DOI: 10.1042/cs20170026

Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype

Autores: Arjan F. Theil, Elena Botta, Anja Raams, Desiree E.C. Smith, Marisa I. Mendes, Giuseppina Caligiuri, Sarah Giachetti, Silvia Bione, Roberta Carriero, Giordano Liberi, Luca Zardoni, Sigrid M.A. Swagemakers, Gajja S. Salomons, Alain Sarasin, Alan Lehmann, Peter J. van der Spek, Tomoo Ogi, Jan H.J. Hoeijmakers, Wim Vermeulen, Donata Orioli
Publicado en: The American Journal of Human Genetics, Edición 105/2, 2019, Página(s) 434-440, ISSN 0002-9297
Editor: University of Chicago Press
DOI: 10.1016/j.ajhg.2019.06.017

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Autores: Marjolein P. Baar, Renata M.C. Brandt, Diana A. Putavet, Julian D.D. Klein, Kasper W.J. Derks, Benjamin R.M. Bourgeois, Sarah Stryeck, Yvonne Rijksen, Hester van Willigenburg, Danny A. Feijtel, Ingrid van der Pluijm, Jeroen Essers, Wiggert A. van Cappellen, Wilfred F. van IJcken, Adriaan B. Houtsmuller, Joris Pothof, Ron W.F. de Bruin, Tobias Madl, Jan H.J. Hoeijmakers, Judith Campisi, Peter L.J.
Publicado en: Cell, Edición 169/1, 2017, Página(s) 132-147.e16, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2017.02.031

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