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Understanding cancer development in BRCA 1/2 mutation carriers for improved Early detection and Risk Control


DNA methylation signatures to predict the cervicovaginal microbiome status.

Author(s): Nuno R. Nené; James E. Barrett; James E. Barrett; Allison Jones; Iona Evans; Daniel Reisel; John F. Timms; Tobias Paprotka; Andreas Leimbach; Dorella Franchi; Nicoletta Colombo; Line Bjørge; Line Bjørge; Michal Zikan; David Cibula; Martin Widschwendter; Martin Widschwendter
Published in: Clinical Epigenetics, Issue 4, 2020, ISSN 1868-7083
Publisher: Springer Nature
DOI: 10.1186/s13148-020-00966-7

Targeting progesterone signaling prevents metastatic ovarian cancer

Author(s): Kim O, Park EY, Kwon SY, Shin S, Emerson RE, Shin YH, DeMayo FJ, Lydon JP, Coffey DM, Hawkins SM, Quilliam LA, Cheon DJ, Fernández FM, Nephew KP, Karpf AR, Widschwendter M, Sood AK, Bast RC Jr, Godwin AK, Miller KD, Cho CH, Kim J.
Published in: PNAS, 2020, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2013595117

Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock

Author(s): James E. Barrett; Chiara Herzog; Yoo-Na Kim; Thomas E. Bartlett; Allison Jones; Iona Evans; David Cibula; Michal Zikan; Line Bjørge; Nadia Harbeck; Nicoletta Colombo; Sacha J. Howell; Angelique Flöter Rådestad; Kristina Gemzell-Danielsson; Martin Widschwendter
Published in: Genome Biology, 2022, ISSN 1474-760X
Publisher: London BioMed Central Ltd 2001-
DOI: 10.1186/s13059-022-02603-3

The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples.

Author(s): James E. Barrett, Chiara Herzog, Allison Jones, Olivia C. Leavy, Iona Evans, Susanne Knapp, Daniel Reisel, Tatiana Nazarenko, Yoo-Na Kim, Dorella Franchi, Andy Ryan, Joanna Franks, Line Bjørge, Michal Zikan, David Cibula, Nadia Harbeck, Nicoletta Colombo, Frank Dudbridge, Louise Jones, Karin Sundström, Joakim Dillner, Angelique Flöter Rådestad, Kristina Gemzell-Danielsson, Nora Pashayan & Mart
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27918-w

The DNA methylome of cervical cells can predict the presence of ovarian cancer

Author(s): James E Barrett, Allison Jones, Iona Evans, Daniel Reisel, Chiara Herzog, Kantaraja Chindera, Mark Kristiansen, Olivia C Leavy, Ranjit Manchanda, Line Bjørge, Michal Zikan, David Cibula, Martin Widschwendter
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26615-y.

Non-Surgical Cancer Risk Reduction in BRCA1 Mutation Carriers: Disabling the Remote Control

Author(s): Martin Widschwendter, Louis Dubeau
Published in: Cancers, Issue 12/3, 2020, Page(s) 547, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12030547

DNA Methylation Patterns in Normal Tissue Correlate more Strongly with Breast Cancer Status than Copy-Number Variants

Author(s): Yang Gao, Martin Widschwendter, Andrew E. Teschendorff
Published in: EBioMedicine, Issue 31, 2018, Page(s) 243-252, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2018.04.025

Do cancer risk and benefit–harm ratios influence women’s consideration of risk-reducing mastectomy? A scenario-based experiment in five European countries

Author(s): Felix G. Rebitschek, Nora Pashayan, Martin Widschwendter, Odette Wegwarth
Published in: PLOS ONE, Issue 14/6, 2019, Page(s) e0218188, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0218188

Prognostic gene expression signature for high-grade serous ovarian cancer

Author(s): J. Millstein, T. Budden, E.L. Goode, M.S. Anglesio, A. Talhouk, M.P. Intermaggio, H.S. Leong, S. Chen, W. Elatre, B. Gilks, T. Nazeran, M. Volchek, R.C. Bentley, C. Wang, D.S. Chiu, S. Kommoss, S.C.Y. Leung, J. Senz, A. Lum, V. Chow, H. Sudderuddin, R. Mackenzie, J. George, S. Fereday, J. Hendley, N. Traficante, H. Steed, J.M. Koziak, M. Köbel, I.A. McNeish, T. Goranova, D. Ennis, G. Macintyre, D
Published in: Annals of Oncology, 2020, ISSN 0923-7534
Publisher: Oxford University Press
DOI: 10.1016/j.annonc.2020.05.019

Epigenome-based cancer risk prediction: rationale, opportunities and challenges

Author(s): Martin Widschwendter, Allison Jones, Iona Evans, Daniel Reisel, Joakim Dillner, Karin Sundström, Ewout W. Steyerberg, Yvonne Vergouwe, Odette Wegwarth, Felix G. Rebitschek, Uwe Siebert, Gaby Sroczynski, Inez D. de Beaufort, Ineke Bolt, David Cibula, Michal Zikan, Line Bjørge, Nicoletta Colombo, Nadia Harbeck, Frank Dudbridge, Anne-Marie Tasse, Bartha M. Knoppers, Yann Joly, Andrew E. Teschendorf
Published in: Nature Reviews Clinical Oncology, Issue 15/5, 2018, Page(s) 292-309, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/nrclinonc.2018.30

Association between the cervicovaginal microbiome, BRCA1 mutation status, and risk of ovarian cancer: a case-control study

Author(s): Nuno R Nené, Daniel Reisel, Andreas Leimbach, Dorella Franchi, Allison Jones, Iona Evans, Susanne Knapp, Andy Ryan, Shohreh Ghazali, John F Timms, Tobias Paprotka, Line Bjørge, Michal Zikan, David Cibula, Nicoletta Colombo, Martin Widschwendter
Published in: The Lancet Oncology, Issue 20/8, 2019, Page(s) 1171-1182, ISSN 1470-2045
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(19)30340-7

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