Understanding cancer development in BRCA 1/2 mutation carriers for improved Early detection and Risk Control

Project Information

BRCA-ERC

Grant agreement ID: 742432

DOI 10.3030/742432

Project closed

EC signature date 14 June 2017

Start date 1 September 2017

End date 31 May 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 497 841,00

EU contribution € 2 497 841,00

Coordinated by

UNIVERSITAET INNSBRUCK
Austria

Publications

Peer reviewed articles (17)

DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test

Author(s): Chiara Herzog; Karin Sundström; Allison Jones; Iona Evans; James E. Barrett; Jiangrong Wang; Elisa Redl; Lena Schreiberhuber; Laura Costas; Sonia Paytubi; Lukas Dostalek; Michal Zikan; David Cibula; Gaby Sroczynski; Uwe Siebert; Joakim Dillner; Martin Widschwendter
Published in: Clinical Epigenetics, 2022, ISSN 1868-7083
Publisher: Springer Nature
DOI: 10.1186/s13148-022-01353-0

DNA methylation signatures to predict the cervicovaginal microbiome status.

Author(s): Nuno R. Nené; James E. Barrett; James E. Barrett; Allison Jones; Iona Evans; Daniel Reisel; John F. Timms; Tobias Paprotka; Andreas Leimbach; Dorella Franchi; Nicoletta Colombo; Line Bjørge; Line Bjørge; Michal Zikan; David Cibula; Martin Widschwendter; Martin Widschwendter
Published in: Clinical Epigenetics, Issue 4, 2020, ISSN 1868-7083
Publisher: Springer Nature
DOI: 10.1186/s13148-020-00966-7

Targeting progesterone signaling prevents metastatic ovarian cancer

Author(s): Kim O, Park EY, Kwon SY, Shin S, Emerson RE, Shin YH, DeMayo FJ, Lydon JP, Coffey DM, Hawkins SM, Quilliam LA, Cheon DJ, Fernández FM, Nephew KP, Karpf AR, Widschwendter M, Sood AK, Bast RC Jr, Godwin AK, Miller KD, Cho CH, Kim J.
Published in: PNAS, 2020, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2013595117

Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women

Author(s): Thomas E. Bartlett; Iona Evans; Allison Jones; James E. Barrett; Shaun Haran; Daniel Reisel; Kiriaki Papaikonomou; Louise Jones; Chiara Herzog; Nora Pashayan; Bruno M. Simões; Robert B. Clarke; D. Gareth Evans; Talayeh S. Ghezelayagh; Sakthivignesh Ponandai-Srinivasan; Nageswara R. Boggavarapu; Parameswaran G. Lalitkumar; Sacha J. Howell; Rosa Ana Risques; Angelique Flöter Rådestad; Louis Dubea
Published in: Genome Medicine, 2022, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-022-01063-5

DNA methylation at quantitative trait loci (mQTLs) varies with cell type and nonheritable factors and may improve breast cancer risk assessment.

Author(s): Herzog C, Jones A, Evans I, Zikan M, Cibula D, Harbeck N, Colombo N, Rådestad AF, Gemzell-Danielsson K, Pashayan N, Widschwendter M.
Published in: npj Precision Oncology, 2023, ISSN 2397-768X
Publisher: Springer Nature
DOI: 10.1038/s41698-023-00452-2

Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock

Author(s): James E. Barrett; Chiara Herzog; Yoo-Na Kim; Thomas E. Bartlett; Allison Jones; Iona Evans; David Cibula; Michal Zikan; Line Bjørge; Nadia Harbeck; Nicoletta Colombo; Sacha J. Howell; Angelique Flöter Rådestad; Kristina Gemzell-Danielsson; Martin Widschwendter
Published in: Genome Biology, 2022, ISSN 1474-760X
Publisher: London BioMed Central Ltd 2001-
DOI: 10.1186/s13059-022-02603-3

The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples.

Author(s): James E. Barrett, Chiara Herzog, Allison Jones, Olivia C. Leavy, Iona Evans, Susanne Knapp, Daniel Reisel, Tatiana Nazarenko, Yoo-Na Kim, Dorella Franchi, Andy Ryan, Joanna Franks, Line Bjørge, Michal Zikan, David Cibula, Nadia Harbeck, Nicoletta Colombo, Frank Dudbridge, Louise Jones, Karin Sundström, Joakim Dillner, Angelique Flöter Rådestad, Kristina Gemzell-Danielsson, Nora Pashayan & Mart
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27918-w

The WID-EC test for the detection and risk prediction of endometrial cancer

Author(s): Barrett JE, Jones A, Evans I, Herzog C, Reisel D, Olaitan A, Mould T, MacDonald N, Doufekas K, Newton C, Crosbie EJ, Bjørge L, Colombo N, Dostalek L, Costas L, Peremiquel-Trillas P, Ponce J, Matias-Guiu X, Zikan M, Cibula D, Wang J, Sundström K, Dillner J, Widschwendter M.
Published in: International Journal of Cancer, 2023, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34406

A Simple Cervicovaginal Epigenetic Test for Screening and Rapid Triage of Women With Suspected Endometrial Cancer: Validation in Several Cohort and Case/Control Sets

Author(s): Herzog C, Marín F, Jones A, Evans I, Reisel D, Redl E, Schreiberhuber L, Paytubi S, Pelegrina B, Carmona Á, Peremiquel-Trillas P, Frias-Gomez J, Pineda M, Brunet J, Ponce J, Matias-Guiu X, de Sanjosé S, Alemany L, Olaitan A, Wong M, Jurkovic D, Crosbie EJ, Rosenthal AN, Bjørge L, Zikan M, Dostalek L, Cibula D, Sundström K, Dillner J, Costas L, Widschwendter M.
Published in: Journal of Clinical Oncology, 2022, ISSN 0732-183X
Publisher: American Society of Clinical Oncology
DOI: 10.1200/jco.22.00266

The DNA methylome of cervical cells can predict the presence of ovarian cancer

Author(s): James E Barrett, Allison Jones, Iona Evans, Daniel Reisel, Chiara Herzog, Kantaraja Chindera, Mark Kristiansen, Olivia C Leavy, Ranjit Manchanda, Line Bjørge, Michal Zikan, David Cibula, Martin Widschwendter
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26615-y.

Non-Surgical Cancer Risk Reduction in BRCA1 Mutation Carriers: Disabling the Remote Control

Author(s): Martin Widschwendter, Louis Dubeau
Published in: Cancers, Issue 12/3, 2020, Page(s) 547, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12030547

Epigenome-based cancer risk prediction: rationale, opportunities and challenges

Author(s): Martin Widschwendter, Allison Jones, Iona Evans, Daniel Reisel, Joakim Dillner, Karin Sundström, Ewout W. Steyerberg, Yvonne Vergouwe, Odette Wegwarth, Felix G. Rebitschek, Uwe Siebert, Gaby Sroczynski, Inez D. de Beaufort, Ineke Bolt, David Cibula, Michal Zikan, Line Bjørge, Nicoletta Colombo, Nadia Harbeck, Frank Dudbridge, Anne-Marie Tasse, Bartha M. Knoppers, Yann Joly, Andrew E. Teschendorf
Published in: Nature Reviews Clinical Oncology, Issue 15/5, 2018, Page(s) 292-309, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/nrclinonc.2018.30

Association between the cervicovaginal microbiome, BRCA1 mutation status, and risk of ovarian cancer: a case-control study

Author(s): Nuno R Nené, Daniel Reisel, Andreas Leimbach, Dorella Franchi, Allison Jones, Iona Evans, Susanne Knapp, Andy Ryan, Shohreh Ghazali, John F Timms, Tobias Paprotka, Line Bjørge, Michal Zikan, David Cibula, Nicoletta Colombo, Martin Widschwendter
Published in: The Lancet Oncology, Issue 20/8, 2019, Page(s) 1171-1182, ISSN 1470-2045
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(19)30340-7

The WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer

Author(s): James E. Barrett; Karin Sundström; Allison Jones; Iona Evans; Jiangrong Wang; Chiara Herzog; Joakim Dillner; Martin Widschwendter
Published in: Genome Medicine, 2022, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-022-01116-9

The <scp>WID‐qEC</scp> test: Performance in a hospital‐based cohort and feasibility to detect endometrial and cervical cancers

Author(s): Lena Schreiberhuber; Chiara Herzog; Charlotte D. Vavourakis; Elisa Redl; Christine Kastner; Allison Jones; Iona Evans; Michal Zikan; David Cibula; Peter Widschwendter; Karin Pfau; Barbara Math; Martin Seewald; Sylvain Amory; Peter Obrist; Martin Widschwendter
Published in: International Journal of Cancer, 2022, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34275

HPV-induced host epigenetic reprogramming is lost upon progression to high-grade cervical intraepithelial neoplasia

Author(s): Herzog C, Vavourakis CD, Barrett JE, Karbon G, Villunger A, Wang J, Sundström K, Dillner J, Widschwendter M.
Published in: International Journal of Cancer, 2023, ISSN 1097-0215
Publisher: Wiley
DOI: 10.1002/ijc.34477

Personalized early detection and prevention of breast cancer: ENVISION consensus statement.

Author(s): Pashayan N, Antoniou AC, Ivanus U, Esserman LJ, Easton DF, French D, Sroczynski G, Hall P, Cuzick J, Evans DG, Simard J, Garcia-Closas M, Schmutzler R, Wegwarth O, Pharoah P, Moorthie S, De Montgolfier S, Baron C, Herceg Z, Turnbull C, Balleyguier C, Rossi PG, Wesseling J, Ritchie D, Tischkowitz M, Broeders M, Reisel D, Metspalu A, Callender T, de Koning H, Devilee P, Delaloge S, Schmidt MK, Widsc
Published in: Nature Reviews Clinical Oncology, 2020, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/s41571-020-0388-9