Understanding cancer development in BRCA 1/2 mutation carriers for improved Early detection and Risk Control

Publications

DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test

Auteurs: Chiara Herzog; Karin Sundström; Allison Jones; Iona Evans; James E. Barrett; Jiangrong Wang; Elisa Redl; Lena Schreiberhuber; Laura Costas; Sonia Paytubi; Lukas Dostalek; Michal Zikan; David Cibula; Gaby Sroczynski; Uwe Siebert; Joakim Dillner; Martin Widschwendter
Publié dans: Clinical Epigenetics, 2022, ISSN 1868-7083
Éditeur: Springer Nature
DOI: 10.1186/s13148-022-01353-0

DNA methylation signatures to predict the cervicovaginal microbiome status.

Auteurs: Nuno R. Nené; James E. Barrett; James E. Barrett; Allison Jones; Iona Evans; Daniel Reisel; John F. Timms; Tobias Paprotka; Andreas Leimbach; Dorella Franchi; Nicoletta Colombo; Line Bjørge; Line Bjørge; Michal Zikan; David Cibula; Martin Widschwendter; Martin Widschwendter
Publié dans: Clinical Epigenetics, Numéro 4, 2020, ISSN 1868-7083
Éditeur: Springer Nature
DOI: 10.1186/s13148-020-00966-7

Targeting progesterone signaling prevents metastatic ovarian cancer

Auteurs: Kim O, Park EY, Kwon SY, Shin S, Emerson RE, Shin YH, DeMayo FJ, Lydon JP, Coffey DM, Hawkins SM, Quilliam LA, Cheon DJ, Fernández FM, Nephew KP, Karpf AR, Widschwendter M, Sood AK, Bast RC Jr, Godwin AK, Miller KD, Cho CH, Kim J.
Publié dans: PNAS, 2020, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2013595117

Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women

Auteurs: Thomas E. Bartlett; Iona Evans; Allison Jones; James E. Barrett; Shaun Haran; Daniel Reisel; Kiriaki Papaikonomou; Louise Jones; Chiara Herzog; Nora Pashayan; Bruno M. Simões; Robert B. Clarke; D. Gareth Evans; Talayeh S. Ghezelayagh; Sakthivignesh Ponandai-Srinivasan; Nageswara R. Boggavarapu; Parameswaran G. Lalitkumar; Sacha J. Howell; Rosa Ana Risques; Angelique Flöter Rådestad; Louis Dubea
Publié dans: Genome Medicine, 2022, ISSN 1756-994X
Éditeur: BioMed Central
DOI: 10.1186/s13073-022-01063-5

DNA methylation at quantitative trait loci (mQTLs) varies with cell type and nonheritable factors and may improve breast cancer risk assessment.

Auteurs: Herzog C, Jones A, Evans I, Zikan M, Cibula D, Harbeck N, Colombo N, Rådestad AF, Gemzell-Danielsson K, Pashayan N, Widschwendter M.
Publié dans: npj Precision Oncology, 2023, ISSN 2397-768X
Éditeur: Springer Nature
DOI: 10.1038/s41698-023-00452-2

Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock

Auteurs: James E. Barrett; Chiara Herzog; Yoo-Na Kim; Thomas E. Bartlett; Allison Jones; Iona Evans; David Cibula; Michal Zikan; Line Bjørge; Nadia Harbeck; Nicoletta Colombo; Sacha J. Howell; Angelique Flöter Rådestad; Kristina Gemzell-Danielsson; Martin Widschwendter
Publié dans: Genome Biology, 2022, ISSN 1474-760X
Éditeur: London BioMed Central Ltd 2001-
DOI: 10.1186/s13059-022-02603-3

The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples.

Auteurs: James E. Barrett, Chiara Herzog, Allison Jones, Olivia C. Leavy, Iona Evans, Susanne Knapp, Daniel Reisel, Tatiana Nazarenko, Yoo-Na Kim, Dorella Franchi, Andy Ryan, Joanna Franks, Line Bjørge, Michal Zikan, David Cibula, Nadia Harbeck, Nicoletta Colombo, Frank Dudbridge, Louise Jones, Karin Sundström, Joakim Dillner, Angelique Flöter Rådestad, Kristina Gemzell-Danielsson, Nora Pashayan & Mart
Publié dans: Nature Communications, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-27918-w

The WID-EC test for the detection and risk prediction of endometrial cancer

Auteurs: Barrett JE, Jones A, Evans I, Herzog C, Reisel D, Olaitan A, Mould T, MacDonald N, Doufekas K, Newton C, Crosbie EJ, Bjørge L, Colombo N, Dostalek L, Costas L, Peremiquel-Trillas P, Ponce J, Matias-Guiu X, Zikan M, Cibula D, Wang J, Sundström K, Dillner J, Widschwendter M.
Publié dans: International Journal of Cancer, 2023, ISSN 0020-7136
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34406

A Simple Cervicovaginal Epigenetic Test for Screening and Rapid Triage of Women With Suspected Endometrial Cancer: Validation in Several Cohort and Case/Control Sets

Auteurs: Herzog C, Marín F, Jones A, Evans I, Reisel D, Redl E, Schreiberhuber L, Paytubi S, Pelegrina B, Carmona Á, Peremiquel-Trillas P, Frias-Gomez J, Pineda M, Brunet J, Ponce J, Matias-Guiu X, de Sanjosé S, Alemany L, Olaitan A, Wong M, Jurkovic D, Crosbie EJ, Rosenthal AN, Bjørge L, Zikan M, Dostalek L, Cibula D, Sundström K, Dillner J, Costas L, Widschwendter M.
Publié dans: Journal of Clinical Oncology, 2022, ISSN 0732-183X
Éditeur: American Society of Clinical Oncology
DOI: 10.1200/jco.22.00266

The DNA methylome of cervical cells can predict the presence of ovarian cancer

Auteurs: James E Barrett, Allison Jones, Iona Evans, Daniel Reisel, Chiara Herzog, Kantaraja Chindera, Mark Kristiansen, Olivia C Leavy, Ranjit Manchanda, Line Bjørge, Michal Zikan, David Cibula, Martin Widschwendter
Publié dans: Nature Communications, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-26615-y.

Non-Surgical Cancer Risk Reduction in BRCA1 Mutation Carriers: Disabling the Remote Control

Auteurs: Martin Widschwendter, Louis Dubeau
Publié dans: Cancers, Numéro 12/3, 2020, Page(s) 547, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12030547

Epigenome-based cancer risk prediction: rationale, opportunities and challenges

Auteurs: Martin Widschwendter, Allison Jones, Iona Evans, Daniel Reisel, Joakim Dillner, Karin Sundström, Ewout W. Steyerberg, Yvonne Vergouwe, Odette Wegwarth, Felix G. Rebitschek, Uwe Siebert, Gaby Sroczynski, Inez D. de Beaufort, Ineke Bolt, David Cibula, Michal Zikan, Line Bjørge, Nicoletta Colombo, Nadia Harbeck, Frank Dudbridge, Anne-Marie Tasse, Bartha M. Knoppers, Yann Joly, Andrew E. Teschendorf
Publié dans: Nature Reviews Clinical Oncology, Numéro 15/5, 2018, Page(s) 292-309, ISSN 1759-4774
Éditeur: Nature Publishing Group
DOI: 10.1038/nrclinonc.2018.30

Association between the cervicovaginal microbiome, BRCA1 mutation status, and risk of ovarian cancer: a case-control study

Auteurs: Nuno R Nené, Daniel Reisel, Andreas Leimbach, Dorella Franchi, Allison Jones, Iona Evans, Susanne Knapp, Andy Ryan, Shohreh Ghazali, John F Timms, Tobias Paprotka, Line Bjørge, Michal Zikan, David Cibula, Nicoletta Colombo, Martin Widschwendter
Publié dans: The Lancet Oncology, Numéro 20/8, 2019, Page(s) 1171-1182, ISSN 1470-2045
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(19)30340-7

The WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer

Auteurs: James E. Barrett; Karin Sundström; Allison Jones; Iona Evans; Jiangrong Wang; Chiara Herzog; Joakim Dillner; Martin Widschwendter
Publié dans: Genome Medicine, 2022, ISSN 1756-994X
Éditeur: BioMed Central
DOI: 10.1186/s13073-022-01116-9

The <scp>WID‐qEC</scp> test: Performance in a hospital‐based cohort and feasibility to detect endometrial and cervical cancers

Auteurs: Lena Schreiberhuber; Chiara Herzog; Charlotte D. Vavourakis; Elisa Redl; Christine Kastner; Allison Jones; Iona Evans; Michal Zikan; David Cibula; Peter Widschwendter; Karin Pfau; Barbara Math; Martin Seewald; Sylvain Amory; Peter Obrist; Martin Widschwendter
Publié dans: International Journal of Cancer, 2022, ISSN 0020-7136
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34275

HPV-induced host epigenetic reprogramming is lost upon progression to high-grade cervical intraepithelial neoplasia

Auteurs: Herzog C, Vavourakis CD, Barrett JE, Karbon G, Villunger A, Wang J, Sundström K, Dillner J, Widschwendter M.
Publié dans: International Journal of Cancer, 2023, ISSN 1097-0215
Éditeur: Wiley
DOI: 10.1002/ijc.34477

Personalized early detection and prevention of breast cancer: ENVISION consensus statement.

Auteurs: Pashayan N, Antoniou AC, Ivanus U, Esserman LJ, Easton DF, French D, Sroczynski G, Hall P, Cuzick J, Evans DG, Simard J, Garcia-Closas M, Schmutzler R, Wegwarth O, Pharoah P, Moorthie S, De Montgolfier S, Baron C, Herceg Z, Turnbull C, Balleyguier C, Rossi PG, Wesseling J, Ritchie D, Tischkowitz M, Broeders M, Reisel D, Metspalu A, Callender T, de Koning H, Devilee P, Delaloge S, Schmidt MK, Widsc
Publié dans: Nature Reviews Clinical Oncology, 2020, ISSN 1759-4774
Éditeur: Nature Publishing Group
DOI: 10.1038/s41571-020-0388-9

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