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Understanding cancer development in BRCA 1/2 mutation carriers for improved Early detection and Risk Control

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DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test

Autoren: Chiara Herzog; Karin Sundström; Allison Jones; Iona Evans; James E. Barrett; Jiangrong Wang; Elisa Redl; Lena Schreiberhuber; Laura Costas; Sonia Paytubi; Lukas Dostalek; Michal Zikan; David Cibula; Gaby Sroczynski; Uwe Siebert; Joakim Dillner; Martin Widschwendter
Veröffentlicht in: Clinical Epigenetics, 2022, ISSN 1868-7083
Herausgeber: Springer Nature
DOI: 10.1186/s13148-022-01353-0

DNA methylation signatures to predict the cervicovaginal microbiome status.

Autoren: Nuno R. Nené; James E. Barrett; James E. Barrett; Allison Jones; Iona Evans; Daniel Reisel; John F. Timms; Tobias Paprotka; Andreas Leimbach; Dorella Franchi; Nicoletta Colombo; Line Bjørge; Line Bjørge; Michal Zikan; David Cibula; Martin Widschwendter; Martin Widschwendter
Veröffentlicht in: Clinical Epigenetics, Issue 4, 2020, ISSN 1868-7083
Herausgeber: Springer Nature
DOI: 10.1186/s13148-020-00966-7

Targeting progesterone signaling prevents metastatic ovarian cancer

Autoren: Kim O, Park EY, Kwon SY, Shin S, Emerson RE, Shin YH, DeMayo FJ, Lydon JP, Coffey DM, Hawkins SM, Quilliam LA, Cheon DJ, Fernández FM, Nephew KP, Karpf AR, Widschwendter M, Sood AK, Bast RC Jr, Godwin AK, Miller KD, Cho CH, Kim J.
Veröffentlicht in: PNAS, 2020, ISSN 0027-8424
Herausgeber: National Academy of Sciences
DOI: 10.1073/pnas.2013595117

Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women

Autoren: Thomas E. Bartlett; Iona Evans; Allison Jones; James E. Barrett; Shaun Haran; Daniel Reisel; Kiriaki Papaikonomou; Louise Jones; Chiara Herzog; Nora Pashayan; Bruno M. Simões; Robert B. Clarke; D. Gareth Evans; Talayeh S. Ghezelayagh; Sakthivignesh Ponandai-Srinivasan; Nageswara R. Boggavarapu; Parameswaran G. Lalitkumar; Sacha J. Howell; Rosa Ana Risques; Angelique Flöter Rådestad; Louis Dubea
Veröffentlicht in: Genome Medicine, 2022, ISSN 1756-994X
Herausgeber: BioMed Central
DOI: 10.1186/s13073-022-01063-5

DNA methylation at quantitative trait loci (mQTLs) varies with cell type and nonheritable factors and may improve breast cancer risk assessment.

Autoren: Herzog C, Jones A, Evans I, Zikan M, Cibula D, Harbeck N, Colombo N, Rådestad AF, Gemzell-Danielsson K, Pashayan N, Widschwendter M.
Veröffentlicht in: npj Precision Oncology, 2023, ISSN 2397-768X
Herausgeber: Springer Nature
DOI: 10.1038/s41698-023-00452-2

Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock

Autoren: James E. Barrett; Chiara Herzog; Yoo-Na Kim; Thomas E. Bartlett; Allison Jones; Iona Evans; David Cibula; Michal Zikan; Line Bjørge; Nadia Harbeck; Nicoletta Colombo; Sacha J. Howell; Angelique Flöter Rådestad; Kristina Gemzell-Danielsson; Martin Widschwendter
Veröffentlicht in: Genome Biology, 2022, ISSN 1474-760X
Herausgeber: London BioMed Central Ltd 2001-
DOI: 10.1186/s13059-022-02603-3

The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples.

Autoren: James E. Barrett, Chiara Herzog, Allison Jones, Olivia C. Leavy, Iona Evans, Susanne Knapp, Daniel Reisel, Tatiana Nazarenko, Yoo-Na Kim, Dorella Franchi, Andy Ryan, Joanna Franks, Line Bjørge, Michal Zikan, David Cibula, Nadia Harbeck, Nicoletta Colombo, Frank Dudbridge, Louise Jones, Karin Sundström, Joakim Dillner, Angelique Flöter Rådestad, Kristina Gemzell-Danielsson, Nora Pashayan & Mart
Veröffentlicht in: Nature Communications, 2022, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-021-27918-w

The WID-EC test for the detection and risk prediction of endometrial cancer

Autoren: Barrett JE, Jones A, Evans I, Herzog C, Reisel D, Olaitan A, Mould T, MacDonald N, Doufekas K, Newton C, Crosbie EJ, Bjørge L, Colombo N, Dostalek L, Costas L, Peremiquel-Trillas P, Ponce J, Matias-Guiu X, Zikan M, Cibula D, Wang J, Sundström K, Dillner J, Widschwendter M.
Veröffentlicht in: International Journal of Cancer, 2023, ISSN 0020-7136
Herausgeber: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34406

A Simple Cervicovaginal Epigenetic Test for Screening and Rapid Triage of Women With Suspected Endometrial Cancer: Validation in Several Cohort and Case/Control Sets

Autoren: Herzog C, Marín F, Jones A, Evans I, Reisel D, Redl E, Schreiberhuber L, Paytubi S, Pelegrina B, Carmona Á, Peremiquel-Trillas P, Frias-Gomez J, Pineda M, Brunet J, Ponce J, Matias-Guiu X, de Sanjosé S, Alemany L, Olaitan A, Wong M, Jurkovic D, Crosbie EJ, Rosenthal AN, Bjørge L, Zikan M, Dostalek L, Cibula D, Sundström K, Dillner J, Costas L, Widschwendter M.
Veröffentlicht in: Journal of Clinical Oncology, 2022, ISSN 0732-183X
Herausgeber: American Society of Clinical Oncology
DOI: 10.1200/jco.22.00266

The DNA methylome of cervical cells can predict the presence of ovarian cancer

Autoren: James E Barrett, Allison Jones, Iona Evans, Daniel Reisel, Chiara Herzog, Kantaraja Chindera, Mark Kristiansen, Olivia C Leavy, Ranjit Manchanda, Line Bjørge, Michal Zikan, David Cibula, Martin Widschwendter
Veröffentlicht in: Nature Communications, 2022, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-021-26615-y.

Non-Surgical Cancer Risk Reduction in BRCA1 Mutation Carriers: Disabling the Remote Control

Autoren: Martin Widschwendter, Louis Dubeau
Veröffentlicht in: Cancers, Issue 12/3, 2020, Page(s) 547, ISSN 2072-6694
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12030547

DNA Methylation Patterns in Normal Tissue Correlate more Strongly with Breast Cancer Status than Copy-Number Variants

Autoren: Yang Gao, Martin Widschwendter, Andrew E. Teschendorff
Veröffentlicht in: EBioMedicine, Issue 31, 2018, Page(s) 243-252, ISSN 2352-3964
Herausgeber: Elsevier BV
DOI: 10.1016/j.ebiom.2018.04.025

Do cancer risk and benefit–harm ratios influence women’s consideration of risk-reducing mastectomy? A scenario-based experiment in five European countries

Autoren: Felix G. Rebitschek, Nora Pashayan, Martin Widschwendter, Odette Wegwarth
Veröffentlicht in: PLOS ONE, Issue 14/6, 2019, Page(s) e0218188, ISSN 1932-6203
Herausgeber: Public Library of Science
DOI: 10.1371/journal.pone.0218188

Prognostic gene expression signature for high-grade serous ovarian cancer

Autoren: J. Millstein, T. Budden, E.L. Goode, M.S. Anglesio, A. Talhouk, M.P. Intermaggio, H.S. Leong, S. Chen, W. Elatre, B. Gilks, T. Nazeran, M. Volchek, R.C. Bentley, C. Wang, D.S. Chiu, S. Kommoss, S.C.Y. Leung, J. Senz, A. Lum, V. Chow, H. Sudderuddin, R. Mackenzie, J. George, S. Fereday, J. Hendley, N. Traficante, H. Steed, J.M. Koziak, M. Köbel, I.A. McNeish, T. Goranova, D. Ennis, G. Macintyre, D
Veröffentlicht in: Annals of Oncology, 2020, ISSN 0923-7534
Herausgeber: Oxford University Press
DOI: 10.1016/j.annonc.2020.05.019

Epigenome-based cancer risk prediction: rationale, opportunities and challenges

Autoren: Martin Widschwendter, Allison Jones, Iona Evans, Daniel Reisel, Joakim Dillner, Karin Sundström, Ewout W. Steyerberg, Yvonne Vergouwe, Odette Wegwarth, Felix G. Rebitschek, Uwe Siebert, Gaby Sroczynski, Inez D. de Beaufort, Ineke Bolt, David Cibula, Michal Zikan, Line Bjørge, Nicoletta Colombo, Nadia Harbeck, Frank Dudbridge, Anne-Marie Tasse, Bartha M. Knoppers, Yann Joly, Andrew E. Teschendorf
Veröffentlicht in: Nature Reviews Clinical Oncology, Issue 15/5, 2018, Page(s) 292-309, ISSN 1759-4774
Herausgeber: Nature Publishing Group
DOI: 10.1038/nrclinonc.2018.30

Association between the cervicovaginal microbiome, BRCA1 mutation status, and risk of ovarian cancer: a case-control study

Autoren: Nuno R Nené, Daniel Reisel, Andreas Leimbach, Dorella Franchi, Allison Jones, Iona Evans, Susanne Knapp, Andy Ryan, Shohreh Ghazali, John F Timms, Tobias Paprotka, Line Bjørge, Michal Zikan, David Cibula, Nicoletta Colombo, Martin Widschwendter
Veröffentlicht in: The Lancet Oncology, Issue 20/8, 2019, Page(s) 1171-1182, ISSN 1470-2045
Herausgeber: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(19)30340-7

The WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer

Autoren: James E. Barrett; Karin Sundström; Allison Jones; Iona Evans; Jiangrong Wang; Chiara Herzog; Joakim Dillner; Martin Widschwendter
Veröffentlicht in: Genome Medicine, 2022, ISSN 1756-994X
Herausgeber: BioMed Central
DOI: 10.1186/s13073-022-01116-9

The <scp>WID‐qEC</scp> test: Performance in a hospital‐based cohort and feasibility to detect endometrial and cervical cancers

Autoren: Lena Schreiberhuber; Chiara Herzog; Charlotte D. Vavourakis; Elisa Redl; Christine Kastner; Allison Jones; Iona Evans; Michal Zikan; David Cibula; Peter Widschwendter; Karin Pfau; Barbara Math; Martin Seewald; Sylvain Amory; Peter Obrist; Martin Widschwendter
Veröffentlicht in: International Journal of Cancer, 2022, ISSN 0020-7136
Herausgeber: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34275

HPV-induced host epigenetic reprogramming is lost upon progression to high-grade cervical intraepithelial neoplasia

Autoren: Herzog C, Vavourakis CD, Barrett JE, Karbon G, Villunger A, Wang J, Sundström K, Dillner J, Widschwendter M.
Veröffentlicht in: International Journal of Cancer, 2023, ISSN 1097-0215
Herausgeber: Wiley
DOI: 10.1002/ijc.34477

Personalized early detection and prevention of breast cancer: ENVISION consensus statement.

Autoren: Pashayan N, Antoniou AC, Ivanus U, Esserman LJ, Easton DF, French D, Sroczynski G, Hall P, Cuzick J, Evans DG, Simard J, Garcia-Closas M, Schmutzler R, Wegwarth O, Pharoah P, Moorthie S, De Montgolfier S, Baron C, Herceg Z, Turnbull C, Balleyguier C, Rossi PG, Wesseling J, Ritchie D, Tischkowitz M, Broeders M, Reisel D, Metspalu A, Callender T, de Koning H, Devilee P, Delaloge S, Schmidt MK, Widsc
Veröffentlicht in: Nature Reviews Clinical Oncology, 2020, ISSN 1759-4774
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41571-020-0388-9

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