Understanding cancer development in BRCA 1/2 mutation carriers for improved Early detection and Risk Control

Informazioni relative al progetto

BRCA-ERC

ID dell’accordo di sovvenzione: 742432

DOI 10.3030/742432

Progetto chiuso

Data della firma CE 14 Giugno 2017

Data di avvio 1 Settembre 2017

Data di completamento 31 Maggio 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 2 497 841,00

Contributo UE € 2 497 841,00

Coordinato da

UNIVERSITAET INNSBRUCK
Austria

Pubblicazioni

Peer reviewed articles (17)

DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test

Autori: Chiara Herzog; Karin Sundström; Allison Jones; Iona Evans; James E. Barrett; Jiangrong Wang; Elisa Redl; Lena Schreiberhuber; Laura Costas; Sonia Paytubi; Lukas Dostalek; Michal Zikan; David Cibula; Gaby Sroczynski; Uwe Siebert; Joakim Dillner; Martin Widschwendter
Pubblicato in: Clinical Epigenetics, 2022, ISSN 1868-7083
Editore: Springer Nature
DOI: 10.1186/s13148-022-01353-0

DNA methylation signatures to predict the cervicovaginal microbiome status.

Autori: Nuno R. Nené; James E. Barrett; James E. Barrett; Allison Jones; Iona Evans; Daniel Reisel; John F. Timms; Tobias Paprotka; Andreas Leimbach; Dorella Franchi; Nicoletta Colombo; Line Bjørge; Line Bjørge; Michal Zikan; David Cibula; Martin Widschwendter; Martin Widschwendter
Pubblicato in: Clinical Epigenetics, Numero 4, 2020, ISSN 1868-7083
Editore: Springer Nature
DOI: 10.1186/s13148-020-00966-7

Targeting progesterone signaling prevents metastatic ovarian cancer

Autori: Kim O, Park EY, Kwon SY, Shin S, Emerson RE, Shin YH, DeMayo FJ, Lydon JP, Coffey DM, Hawkins SM, Quilliam LA, Cheon DJ, Fernández FM, Nephew KP, Karpf AR, Widschwendter M, Sood AK, Bast RC Jr, Godwin AK, Miller KD, Cho CH, Kim J.
Pubblicato in: PNAS, 2020, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2013595117

Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women

Autori: Thomas E. Bartlett; Iona Evans; Allison Jones; James E. Barrett; Shaun Haran; Daniel Reisel; Kiriaki Papaikonomou; Louise Jones; Chiara Herzog; Nora Pashayan; Bruno M. Simões; Robert B. Clarke; D. Gareth Evans; Talayeh S. Ghezelayagh; Sakthivignesh Ponandai-Srinivasan; Nageswara R. Boggavarapu; Parameswaran G. Lalitkumar; Sacha J. Howell; Rosa Ana Risques; Angelique Flöter Rådestad; Louis Dubea
Pubblicato in: Genome Medicine, 2022, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-022-01063-5

DNA methylation at quantitative trait loci (mQTLs) varies with cell type and nonheritable factors and may improve breast cancer risk assessment.

Autori: Herzog C, Jones A, Evans I, Zikan M, Cibula D, Harbeck N, Colombo N, Rådestad AF, Gemzell-Danielsson K, Pashayan N, Widschwendter M.
Pubblicato in: npj Precision Oncology, 2023, ISSN 2397-768X
Editore: Springer Nature
DOI: 10.1038/s41698-023-00452-2

Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock

Autori: James E. Barrett; Chiara Herzog; Yoo-Na Kim; Thomas E. Bartlett; Allison Jones; Iona Evans; David Cibula; Michal Zikan; Line Bjørge; Nadia Harbeck; Nicoletta Colombo; Sacha J. Howell; Angelique Flöter Rådestad; Kristina Gemzell-Danielsson; Martin Widschwendter
Pubblicato in: Genome Biology, 2022, ISSN 1474-760X
Editore: London BioMed Central Ltd 2001-
DOI: 10.1186/s13059-022-02603-3

The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples.

Autori: James E. Barrett, Chiara Herzog, Allison Jones, Olivia C. Leavy, Iona Evans, Susanne Knapp, Daniel Reisel, Tatiana Nazarenko, Yoo-Na Kim, Dorella Franchi, Andy Ryan, Joanna Franks, Line Bjørge, Michal Zikan, David Cibula, Nadia Harbeck, Nicoletta Colombo, Frank Dudbridge, Louise Jones, Karin Sundström, Joakim Dillner, Angelique Flöter Rådestad, Kristina Gemzell-Danielsson, Nora Pashayan & Mart
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-27918-w

The WID-EC test for the detection and risk prediction of endometrial cancer

Autori: Barrett JE, Jones A, Evans I, Herzog C, Reisel D, Olaitan A, Mould T, MacDonald N, Doufekas K, Newton C, Crosbie EJ, Bjørge L, Colombo N, Dostalek L, Costas L, Peremiquel-Trillas P, Ponce J, Matias-Guiu X, Zikan M, Cibula D, Wang J, Sundström K, Dillner J, Widschwendter M.
Pubblicato in: International Journal of Cancer, 2023, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34406

A Simple Cervicovaginal Epigenetic Test for Screening and Rapid Triage of Women With Suspected Endometrial Cancer: Validation in Several Cohort and Case/Control Sets

Autori: Herzog C, Marín F, Jones A, Evans I, Reisel D, Redl E, Schreiberhuber L, Paytubi S, Pelegrina B, Carmona Á, Peremiquel-Trillas P, Frias-Gomez J, Pineda M, Brunet J, Ponce J, Matias-Guiu X, de Sanjosé S, Alemany L, Olaitan A, Wong M, Jurkovic D, Crosbie EJ, Rosenthal AN, Bjørge L, Zikan M, Dostalek L, Cibula D, Sundström K, Dillner J, Costas L, Widschwendter M.
Pubblicato in: Journal of Clinical Oncology, 2022, ISSN 0732-183X
Editore: American Society of Clinical Oncology
DOI: 10.1200/jco.22.00266

The DNA methylome of cervical cells can predict the presence of ovarian cancer

Autori: James E Barrett, Allison Jones, Iona Evans, Daniel Reisel, Chiara Herzog, Kantaraja Chindera, Mark Kristiansen, Olivia C Leavy, Ranjit Manchanda, Line Bjørge, Michal Zikan, David Cibula, Martin Widschwendter
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-26615-y.

Non-Surgical Cancer Risk Reduction in BRCA1 Mutation Carriers: Disabling the Remote Control

Autori: Martin Widschwendter, Louis Dubeau
Pubblicato in: Cancers, Numero 12/3, 2020, Pagina/e 547, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12030547

Epigenome-based cancer risk prediction: rationale, opportunities and challenges

Autori: Martin Widschwendter, Allison Jones, Iona Evans, Daniel Reisel, Joakim Dillner, Karin Sundström, Ewout W. Steyerberg, Yvonne Vergouwe, Odette Wegwarth, Felix G. Rebitschek, Uwe Siebert, Gaby Sroczynski, Inez D. de Beaufort, Ineke Bolt, David Cibula, Michal Zikan, Line Bjørge, Nicoletta Colombo, Nadia Harbeck, Frank Dudbridge, Anne-Marie Tasse, Bartha M. Knoppers, Yann Joly, Andrew E. Teschendorf
Pubblicato in: Nature Reviews Clinical Oncology, Numero 15/5, 2018, Pagina/e 292-309, ISSN 1759-4774
Editore: Nature Publishing Group
DOI: 10.1038/nrclinonc.2018.30

Association between the cervicovaginal microbiome, BRCA1 mutation status, and risk of ovarian cancer: a case-control study

Autori: Nuno R Nené, Daniel Reisel, Andreas Leimbach, Dorella Franchi, Allison Jones, Iona Evans, Susanne Knapp, Andy Ryan, Shohreh Ghazali, John F Timms, Tobias Paprotka, Line Bjørge, Michal Zikan, David Cibula, Nicoletta Colombo, Martin Widschwendter
Pubblicato in: The Lancet Oncology, Numero 20/8, 2019, Pagina/e 1171-1182, ISSN 1470-2045
Editore: The Lancet Publishing Group
DOI: 10.1016/s1470-2045(19)30340-7

The WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer

Autori: James E. Barrett; Karin Sundström; Allison Jones; Iona Evans; Jiangrong Wang; Chiara Herzog; Joakim Dillner; Martin Widschwendter
Pubblicato in: Genome Medicine, 2022, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-022-01116-9

The <scp>WID‐qEC</scp> test: Performance in a hospital‐based cohort and feasibility to detect endometrial and cervical cancers

Autori: Lena Schreiberhuber; Chiara Herzog; Charlotte D. Vavourakis; Elisa Redl; Christine Kastner; Allison Jones; Iona Evans; Michal Zikan; David Cibula; Peter Widschwendter; Karin Pfau; Barbara Math; Martin Seewald; Sylvain Amory; Peter Obrist; Martin Widschwendter
Pubblicato in: International Journal of Cancer, 2022, ISSN 0020-7136
Editore: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34275

HPV-induced host epigenetic reprogramming is lost upon progression to high-grade cervical intraepithelial neoplasia

Autori: Herzog C, Vavourakis CD, Barrett JE, Karbon G, Villunger A, Wang J, Sundström K, Dillner J, Widschwendter M.
Pubblicato in: International Journal of Cancer, 2023, ISSN 1097-0215
Editore: Wiley
DOI: 10.1002/ijc.34477

Personalized early detection and prevention of breast cancer: ENVISION consensus statement.

Autori: Pashayan N, Antoniou AC, Ivanus U, Esserman LJ, Easton DF, French D, Sroczynski G, Hall P, Cuzick J, Evans DG, Simard J, Garcia-Closas M, Schmutzler R, Wegwarth O, Pharoah P, Moorthie S, De Montgolfier S, Baron C, Herceg Z, Turnbull C, Balleyguier C, Rossi PG, Wesseling J, Ritchie D, Tischkowitz M, Broeders M, Reisel D, Metspalu A, Callender T, de Koning H, Devilee P, Delaloge S, Schmidt MK, Widsc
Pubblicato in: Nature Reviews Clinical Oncology, 2020, ISSN 1759-4774
Editore: Nature Publishing Group
DOI: 10.1038/s41571-020-0388-9