Dissecting and targeting ubiquitin networks in the course of bacterial infections

Project Information

Ub-BAC

Grant agreement ID: 742720

DOI 10.3030/742720

Project closed

EC signature date 8 June 2017

Start date 1 July 2017

End date 30 June 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 500 000,00

EU contribution € 2 500 000,00

Coordinated by

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany

Publications

Non-peer reviewed articles (1)

Gasdermin B in the host–pathogen tug-of-war

Author(s): Maculins, T & Dikic I
Published in: Cell Research, Issue 31, 2021, Page(s) 1043-1044, ISSN 1001-0602
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.1038/s41422-021-00544-3

Peer reviewed articles (17)

Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.

Author(s): Lee A. Armstrong; Sven M. Lange; Virginia Dee Cesare; Stephen P. Matthews; Raja Sekhar Nirujogi; Isobel Cole; Anthony G. Hope; Fraser Cunningham; Rachel Toth; Rukmini Mukherjee; Denisa Bojkova; Franz S. Gruber; David W. Gray; Paul G. Wyatt; Jindrich Cinatl; Ivan Dikic; Ivan Dikic; Paul Davies; Yogesh Kulathu
Published in: PLoS ONE, Issue 4, 2021, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0253364

SIK2 orchestrates actin-dependent host response uponSalmonella infection

Author(s): Marcel Hahn, Adriana Covarrubias-Pinto, Lina Herhaus, Shankha Satpathy, Kevin Klann, Keith B. Boyle, Christian Münch, Krishnaraj Rajalingam, Felix Randow, Chunaram Choudhary, and Ivan Dikic
Published in: Proceedings of the National Academy of Sciences, Issue 118(19), 2021, ISSN 1091-6490
Publisher: PNAS
DOI: 10.1073/pnas.2024144118

Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination

Author(s): Sissy Kalayil, Sagar Bhogaraju, Florian Bonn, Donghyuk Shin, Yaobin Liu, Ninghai Gan, Jérôme Basquin, Paolo Grumati, Zhao-Qing Luo, Ivan Dikic
Published in: Nature, Issue 557/7707, 2018, Page(s) 734-738, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0145-8

Mechanism and medical implications of mammalian autophagy

Author(s): Ivan Dikic, Zvulun Elazar
Published in: Nature Reviews Molecular Cell Biology, Issue 19/6, 2018, Page(s) 349-364, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-018-0003-4

Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy

Author(s): Ramachandra M. Bhaskara, Paolo Grumati, Javier Garcia-Pardo, Sissy Kalayil, Adriana Covarrubias-Pinto, Wenbo Chen, Mikhail Kudryashev, Ivan Dikic, Gerhard Hummer
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-10345-3

A selective ER ‐phagy exerts procollagen quality control via a Calnexin‐ FAM 134B complex

Author(s): Alison Forrester, Chiara De Leonibus, Paolo Grumati, Elisa Fasana, Marilina Piemontese, Leopoldo Staiano, Ilaria Fregno, Andrea Raimondi, Alessandro Marazza, Gemma Bruno, Maria Iavazzo, Daniela Intartaglia, Marta Seczynska, Eelco Anken, Ivan Conte, Maria Antonietta De Matteis, Ivan Dikic, Maurizio Molinari, Carmine Settembre
Published in: The EMBO Journal, Issue 38/2, 2018, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201899847

ER-phagy and human diseases

Author(s): Christian A. Hübner, Ivan Dikic
Published in: Cell Death & Differentiation, 2019, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-019-0444-0

Cellular quality control by the ubiquitin-proteasome system and autophagy

Author(s): Christian Pohl, Ivan Dikic
Published in: Science, Issue 366/6467, 2019, Page(s) 818-822, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax3769

CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection

Author(s): Kyoko E. Yuki, Hadir Marei, Evgenij Fiskin, Megan M. Eva, Angelica A. Gopal, Jeremy A. Schwartzentruber, Jacek Majewski, Mathieu Cellier, Judith N. Mandl, Silvia M. Vidal, Danielle Malo, Ivan Dikic
Published in: Nature Microbiology, Issue 4/9, 2019, Page(s) 1516-1531, ISSN 2058-5276
Publisher: Nature Publishing Group
DOI: 10.1038/s41564-019-0484-8

Ubiquitin signaling and autophagy

Author(s): Paolo Grumati, Ivan Dikic
Published in: Journal of Biological Chemistry, Issue 293/15, 2018, Page(s) 5404-5413, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.tm117.000117

Open questions: why should we care about ER-phagy and ER remodelling?

Author(s): Ivan Dikic
Published in: BMC Biology, Issue 16/1, 2018, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-018-0603-7

ER-phagy at a glance

Author(s): Paolo Grumati, Ivan Dikic, Alexandra Stolz
Published in: Journal of Cell Science, Issue 131/17, 2018, Page(s) jcs217364, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.217364

Dimerization quality control via ubiquitylation

Author(s): Lina Herhaus, Ivan Dikic
Published in: Science, Issue 362/6411, 2018, Page(s) 151-152, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aav1391

Inhibition of bacterial ubiquitin ligases by SidJ–calmodulin catalysed glutamylation

Author(s): Sagar Bhogaraju, Florian Bonn, Rukmini Mukherjee, Michael Adams, Moritz M. Pfleiderer, Wojciech P. Galej, Vigor Matkovic, Jaime Lopez-Mosqueda, Sissy Kalayil, Donghyuk Shin, Ivan Dikic
Published in: Nature, Issue 572/7769, 2019, Page(s) 382-386, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1440-8

Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB

Author(s): Donghyuk Shin, Rukmini Mukherjee, Yaobin Liu, Alexis Gonzalez, Florian Bonn, Yan Liu, Vladimir V. Rogov, Marcel Heinz, Alexandra Stolz, Gerhard Hummer, Volker Dötsch, Zhao-Qing Luo, Sagar Bhogaraju, Ivan Dikic
Published in: Molecular Cell, Issue 77/1, 2020, Page(s) 164-179.e6, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.10.019

Mitochondrial Functions in Infection and Immunity

Author(s): Varnesh Tiku, Man-Wah Tan, Ivan Dikic
Published in: Trends in Cell Biology, Issue 30/4, 2020, Page(s) 263-275, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2020.01.006

Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection

Author(s): Liu Y, Mukherjee R, Bonn F, Colby T, Matic I, Glogger M, Heilemann M, Dikic I
Published in: Cell Death & Differntiation, Issue 28, 2021, Page(s) 2957-2969, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-021-00830-y