Biocatalytic Amine Synthesis via Hydrogen Borrowing

Información del proyecto

BIO-H-BORROW

Identificador del acuerdo de subvención: 742987

DOI

10.3030/742987

Proyecto cerrado

Fecha de la firma de la CE 8 Mayo 2017

Fecha de inicio 1 Junio 2017

Fecha de finalización 31 Mayo 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 337 548,00

Aportación de la UE

€ 2 337 548,00

Coordinado por

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (32)

A biocatalytic cascade for the conversion of fatty acids to fatty amines

Autores: Joan Citoler, Sasha R. Derrington, James L. Galman, Han Bevinakattib, Nicholas J. Turner
Publicado en: Green Chemistry, 2019, ISSN 1463-9262
Editor: Royal Society of Chemistry
DOI: 10.1039/c9gc02260k

Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering

Autores: James R. Marshall; Juan Mangas-Sanchez; Juan Mangas-Sanchez; Nicholas J. Turner
Publicado en: Tetrahedron, Edición 82, 26, 2021, Página(s) 131926, ISSN 0040-4020
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.tet.2021.131926

Redox surrogate methods for sustainable amine N-alkylation

Autores: Rebecca E. Ruscoe, Jeremy I. Ramsden, Nicholas JTurner
Publicado en: Current Opinion in Chemical Engineering, 2020, ISSN 2211-3398
Editor: Elsevier BV
DOI: 10.1016/j.coche.2020.08.005

Synthesis of Stereoenriched Piperidines via Chemo-Enzymatic Dearomatization of Activated Pyridines

Autores: Vanessa Harawa; Thomas W. Thorpe; James R. Marshall; Jack J. Sangster; Amelia K. Gilio; Lucian Pirvu; Rachel S. Heath; Antonio Angelastro; James D. Finnigan; Simon J. Charnock; Jordan W. Nafie; Gideon Grogan; Roger C. Whitehead; Nicholas J. Turner
Publicado en: Journal of the American Chemical Society, Edición 144, 46, 2022, Página(s) 21088–21095, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.2c07143

An Engineered Cholesterol Oxidase Catalyses Enantioselective Oxidation of Non-steroidal Secondary Alcohols.

Autores: Rachel S. Heath; Jack J. Sangster; Nicholas J. Turner
Publicado en: ChemBioChem, Edición 23, 7, 2022, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202200075

Is it time for biocatalysis in fragment-based drug discovery?

Autores: Jeremy I. Ramsden; Sebastian C. Cosgrove; Nicholas J. Turner
Publicado en: Chemical Science, Edición 8, 2020, Página(s) 11104-11112, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d0sc04103c

Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination

Autores: James R. Marshall, Peiyuan Yao, Sarah L. Montgomery, James D. Finnigan, Thomas W. Thorpe, Ryan B. Palmer, Juan Mangas-Sanchez, Richard A. M. Duncan, Rachel S. Heath, Kirsty M. Graham, Darren J. Cook, Simon J. Charnock, Nicholas J. Turner
Publicado en: Nature Chemistry, 2021, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-020-00606-w

Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination

Autores: Peiyuan Yao, James R. Marshall, Zefei Xu, Jesmine Lim, Simon J. Charnock, Dunming Zhu, Nicholas J. Turner
Publicado en: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202016589

Enzymatic Late-Stage Modifications: Better Late Than Never

Autores: Elvira Romero, Bethan S. Jones, Bethany N. Hogg, Arnau Rué Casamajo, Martin A. Hayes, Sabine L. Flitsch, Nicholas J. Turner, Christian Schnepel
Publicado en: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202014931

One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald-Hartwig N-Arylation.

Autores: Sebastian C. Cosgrove; Matthew P. Thompson; Syed T. Ahmed; Fabio Parmeggiani; Fabio Parmeggiani; Nicholas J. Turner
Publicado en: Angewandte Chemie International, Edición 8, 2020, Página(s) 18156-18160, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202006246

Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

Autores: James L. Galman, Iustina Slabu, Fabio Parmeggiani, Nicholas J. Turner
Publicado en: Chemical Communications, Edición 54/80, 2018, Página(s) 11316-11319, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/C8CC06759G

Chemo-enzymatic synthesis of pyrazines and pyrroles

Autores: Nicholas John Turner, Anthony Green, Jin Xu
Publicado en: Angewandte Chemie International Edition, 2018, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201810555

Biocatalytic N -Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades

Autores: Jeremy I. Ramsden, Rachel S. Heath, Sasha R. Derrington, Sarah L. Montgomery, Juan Mangas-Sanchez, Keith R. Mulholland, Nicholas J. Turner
Publicado en: Journal of the American Chemical Society, Edición 141/3, 2019, Página(s) 1201-1206, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.8b11561

A generic platform for the immobilisation of engineered biocatalysts

Autores: Matthew P. Thompson, Sasha R. Derrington, Rachel S. Heath, Joanne L. Porter, Juan Mangas-Sanchez, Paul N. Devine, Matthew D. Truppo, Nicholas J. Turner
Publicado en: Tetrahedron, Edición 75/3, 2019, Página(s) 327-334, ISSN 0040-4020
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.tet.2018.12.004

Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores

Autores: Lei Wan, Rachel S. Heath, Bhavin Siritanaratkul, Clare F. Megarity, Adam J. Sills, Matthew P. Thompson, Nicholas J. Turner, Fraser A. Armstrong
Publicado en: Green Chemistry, Edición 21/18, 2019, Página(s) 4958-4963, ISSN 1463-9262
Editor: Royal Society of Chemistry
DOI: 10.1039/c9gc01534e

One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N -Heterocycles

Autores: Thomas W. Thorpe, Scott P. France, Shahed Hussain, James R. Marshall, Wojciech Zawodny, Juan Mangas-Sanchez, Sarah L. Montgomery, Roger M. Howard, David S. B. Daniels, Rajesh Kumar, Fabio Parmeggiani, Nicholas J. Turner
Publicado en: Journal of the American Chemical Society, Edición 141/49, 2019, Página(s) 19208-19213, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.9b10053

Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

Autores: Clare F. Megarity, Bhavin Siritanaratkul, Rachel S. Heath, Lei Wan, Giorgio Morello, Sarah R. FitzPatrick, Rosalind L. Booth, Adam J. Sills, Alexander W. Robertson, Jamie H. Warner, Nicholas J. Turner, Fraser A. Armstrong
Publicado en: Angewandte Chemie International Edition, Edición 58/15, 2019, Página(s) 4948-4952, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201814370

Enantioselective Synthesis of Chiral Vicinal Amino Alcohols Using Amine Dehydrogenases

Autores: Fei-Fei Chen, Sebastian C. Cosgrove, William R. Birmingham, Juan Mangas-Sanchez, Joan Citoler, Matthew P. Thompson, Gao-Wei Zheng, Jian-He Xu, Nicholas J. Turner
Publicado en: ACS Catalysis, Edición 9/12, 2019, Página(s) 11813-11818, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.9b03889

Biocatalytic Routes to Enantiomerically Enriched Dibenz[ c , e ]azepines

Autores: Scott P. France, Godwin A. Aleku, Mahima Sharma, Juan Mangas-Sanchez, Roger M. Howard, Jeremy Steflik, Rajesh Kumar, Ralph W. Adams, Iustina Slabu, Robert Crook, Gideon Grogan, Timothy W. Wallace, Nicholas J. Turner
Publicado en: Angewandte Chemie, Edición 129/49, 2017, Página(s) 15795-15799, ISSN 0044-8249
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201708453

Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

Autores: Iustina Slabu, James L. Galman, Richard C. Lloyd, Nicholas J. Turner
Publicado en: ACS Catalysis, Edición 7/12, 2017, Página(s) 8263-8284, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.7b02686

Bio-derived production of cinnamyl alcohol via a three step biocatalytic cascade and metabolic engineering

Autores: Evaldas Klumbys, Ziga Zebec, Nicholas J. Weise, Nicholas J. Turner, Nigel S. Scrutton
Publicado en: Green Chemistry, Edición 20/3, 2018, Página(s) 658-663, ISSN 1463-9262
Editor: Royal Society of Chemistry
DOI: 10.1039/c7gc03325g

Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase

Autores: Godwin A. Aleku, Juan Mangas-Sanchez, Joan Citoler, Scott P. France, Sarah L. Montgomery, Rachel S. Heath, Matthew P. Thompson, Nicholas J. Turner
Publicado en: ChemCatChem, Edición 10/3, 2018, Página(s) 515-519, ISSN 1867-3880
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201701484

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination

Autores: Scott P. France, Roger M. Howard, Jeremy Steflik, Nicholas J. Weise, Juan Mangas-Sanchez, Sarah L. Montgomery, Robert Crook, Rajesh Kumar, Nicholas J. Turner
Publicado en: ChemCatChem, Edición 10/3, 2018, Página(s) 510-514, ISSN 1867-3880
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201701408

A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases

Autores: Mahima Sharma, Juan Mangas-Sanchez, Scott P. France, Godwin A. Aleku, Sarah L. Montgomery, Jeremy I. Ramsden, Nicholas J. Turner, Gideon Grogan
Publicado en: ACS Catalysis, Edición 8/12, 2018, Página(s) 11534-11541, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.8b03491

Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships

Autores: Sarah L. Montgomery, Ahir Pushpanath, Rachel S. Heath, James R. Marshall, Ulrike Klemstein, James L. Galman, David Woodlock, Serena Bisagni, Christopher J. Taylor, J. Mangas-Sanchez, J. I. Ramsden, Beatriz Dominguez, Nicholas J. Turner
Publicado en: Science Advances, Edición 6/21, 2020, Página(s) eaay9320, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.aay9320

Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases

Autores: Juan Mangas-Sanchez, Mahima Sharma, Sebastian C. Cosgrove, Jeremy I. Ramsden, James R. Marshall, Thomas W. Thorpe, Ryan B. Palmer, Gideon Grogan, Nicholas J. Turner
Publicado en: Chemical Science, Edición 11/19, 2020, Página(s) 5052-5057, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d0sc02253e

One-Step Biocatalytic Synthesis of Sustainable Surfactants by Selective Amide Bond Formation.

Autores: Max Lubberink; William Finnigan; Christian Schnepel; Christopher R. Baldwin; Nicholas J. Turner; Sabine L. Flitsch
Publicado en: Angewandte Chemie International Edition, Edición 61, 30, 2022, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202205054

RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades

Autores: William Finnigan, Lorna J. Hepworth, Sabine L. Flitsch, Nicholas J. Turner
Publicado en: Nature Catalysis, 2021, ISSN 2520-1158
Editor: Nature Publishing Group
DOI: 10.1038/s41929-020-00556-z

New Trends and Future Opportunities in the Enzymatic Formation of C-C, C-N, and C-O bonds.

Autores: Jack J. Sangster; James R. Marshall; Nicholas J. Turner; Juan Mangas-Sanchez
Publicado en: ChemBioChem, Edición 23, 6, 2022, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100464

One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines

Autores: Jack J. Sangster; Rebecca E. Ruscoe; Sebastian C. Cosgrove; Juan Mangas-Sánchez; Nicholas J. Turner
Publicado en: Journal of the American Chemical Society, Edición 145, 8, 2023, Página(s) 4431–4437, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.2c09176

One-Pot Biocatalytic Synthesis of Substituted d-Tryptophans from Indoles Enabled by an Engineered Aminotransferase

Autores: Fabio Parmeggiani, Arnau Rué Casamajo, Curtis J. W. Walton, James L. Galman, Nicholas J. Turner, Roberto A. Chica
Publicado en: ACS Catalysis, 2019, Página(s) 3482–3486, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.9b00739

Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades

Autores: Grayson J. Ford, Nico Kress, Ashley P. Mattey, Lorna J. Hepworth, Christopher R. Baldwin, James R. Marshall, Lisa S. Seibt, Min Huang, William R. Birmingham, Nicholas J. Turner, Sabine L. Flitsch
Publicado en: Chemical Communications, 2020, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d0cc02976a