Biocatalytic Amine Synthesis via Hydrogen Borrowing

Informazioni relative al progetto

BIO-H-BORROW

ID dell’accordo di sovvenzione: 742987

DOI

10.3030/742987

Progetto chiuso

Data della firma CE 8 Maggio 2017

Data di avvio 1 Giugno 2017

Data di completamento 31 Maggio 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 337 548,00

Contributo UE

€ 2 337 548,00

Coordinato da

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (32)

A biocatalytic cascade for the conversion of fatty acids to fatty amines

Autori: Joan Citoler, Sasha R. Derrington, James L. Galman, Han Bevinakattib, Nicholas J. Turner
Pubblicato in: Green Chemistry, 2019, ISSN 1463-9262
Editore: Royal Society of Chemistry
DOI: 10.1039/c9gc02260k

Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering

Autori: James R. Marshall; Juan Mangas-Sanchez; Juan Mangas-Sanchez; Nicholas J. Turner
Pubblicato in: Tetrahedron, Numero 82, 26, 2021, Pagina/e 131926, ISSN 0040-4020
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.tet.2021.131926

Redox surrogate methods for sustainable amine N-alkylation

Autori: Rebecca E. Ruscoe, Jeremy I. Ramsden, Nicholas JTurner
Pubblicato in: Current Opinion in Chemical Engineering, 2020, ISSN 2211-3398
Editore: Elsevier BV
DOI: 10.1016/j.coche.2020.08.005

Synthesis of Stereoenriched Piperidines via Chemo-Enzymatic Dearomatization of Activated Pyridines

Autori: Vanessa Harawa; Thomas W. Thorpe; James R. Marshall; Jack J. Sangster; Amelia K. Gilio; Lucian Pirvu; Rachel S. Heath; Antonio Angelastro; James D. Finnigan; Simon J. Charnock; Jordan W. Nafie; Gideon Grogan; Roger C. Whitehead; Nicholas J. Turner
Pubblicato in: Journal of the American Chemical Society, Numero 144, 46, 2022, Pagina/e 21088–21095, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c07143

An Engineered Cholesterol Oxidase Catalyses Enantioselective Oxidation of Non-steroidal Secondary Alcohols.

Autori: Rachel S. Heath; Jack J. Sangster; Nicholas J. Turner
Pubblicato in: ChemBioChem, Numero 23, 7, 2022, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202200075

Is it time for biocatalysis in fragment-based drug discovery?

Autori: Jeremy I. Ramsden; Sebastian C. Cosgrove; Nicholas J. Turner
Pubblicato in: Chemical Science, Numero 8, 2020, Pagina/e 11104-11112, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc04103c

Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination

Autori: James R. Marshall, Peiyuan Yao, Sarah L. Montgomery, James D. Finnigan, Thomas W. Thorpe, Ryan B. Palmer, Juan Mangas-Sanchez, Richard A. M. Duncan, Rachel S. Heath, Kirsty M. Graham, Darren J. Cook, Simon J. Charnock, Nicholas J. Turner
Pubblicato in: Nature Chemistry, 2021, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-020-00606-w

Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination

Autori: Peiyuan Yao, James R. Marshall, Zefei Xu, Jesmine Lim, Simon J. Charnock, Dunming Zhu, Nicholas J. Turner
Pubblicato in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202016589

Enzymatic Late-Stage Modifications: Better Late Than Never

Autori: Elvira Romero, Bethan S. Jones, Bethany N. Hogg, Arnau Rué Casamajo, Martin A. Hayes, Sabine L. Flitsch, Nicholas J. Turner, Christian Schnepel
Pubblicato in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202014931

One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald-Hartwig N-Arylation.

Autori: Sebastian C. Cosgrove; Matthew P. Thompson; Syed T. Ahmed; Fabio Parmeggiani; Fabio Parmeggiani; Nicholas J. Turner
Pubblicato in: Angewandte Chemie International, Numero 8, 2020, Pagina/e 18156-18160, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202006246

Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

Autori: James L. Galman, Iustina Slabu, Fabio Parmeggiani, Nicholas J. Turner
Pubblicato in: Chemical Communications, Numero 54/80, 2018, Pagina/e 11316-11319, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/C8CC06759G

Chemo-enzymatic synthesis of pyrazines and pyrroles

Autori: Nicholas John Turner, Anthony Green, Jin Xu
Pubblicato in: Angewandte Chemie International Edition, 2018, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201810555

Biocatalytic N -Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades

Autori: Jeremy I. Ramsden, Rachel S. Heath, Sasha R. Derrington, Sarah L. Montgomery, Juan Mangas-Sanchez, Keith R. Mulholland, Nicholas J. Turner
Pubblicato in: Journal of the American Chemical Society, Numero 141/3, 2019, Pagina/e 1201-1206, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.8b11561

A generic platform for the immobilisation of engineered biocatalysts

Autori: Matthew P. Thompson, Sasha R. Derrington, Rachel S. Heath, Joanne L. Porter, Juan Mangas-Sanchez, Paul N. Devine, Matthew D. Truppo, Nicholas J. Turner
Pubblicato in: Tetrahedron, Numero 75/3, 2019, Pagina/e 327-334, ISSN 0040-4020
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.tet.2018.12.004

Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores

Autori: Lei Wan, Rachel S. Heath, Bhavin Siritanaratkul, Clare F. Megarity, Adam J. Sills, Matthew P. Thompson, Nicholas J. Turner, Fraser A. Armstrong
Pubblicato in: Green Chemistry, Numero 21/18, 2019, Pagina/e 4958-4963, ISSN 1463-9262
Editore: Royal Society of Chemistry
DOI: 10.1039/c9gc01534e

One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N -Heterocycles

Autori: Thomas W. Thorpe, Scott P. France, Shahed Hussain, James R. Marshall, Wojciech Zawodny, Juan Mangas-Sanchez, Sarah L. Montgomery, Roger M. Howard, David S. B. Daniels, Rajesh Kumar, Fabio Parmeggiani, Nicholas J. Turner
Pubblicato in: Journal of the American Chemical Society, Numero 141/49, 2019, Pagina/e 19208-19213, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.9b10053

Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

Autori: Clare F. Megarity, Bhavin Siritanaratkul, Rachel S. Heath, Lei Wan, Giorgio Morello, Sarah R. FitzPatrick, Rosalind L. Booth, Adam J. Sills, Alexander W. Robertson, Jamie H. Warner, Nicholas J. Turner, Fraser A. Armstrong
Pubblicato in: Angewandte Chemie International Edition, Numero 58/15, 2019, Pagina/e 4948-4952, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201814370

Enantioselective Synthesis of Chiral Vicinal Amino Alcohols Using Amine Dehydrogenases

Autori: Fei-Fei Chen, Sebastian C. Cosgrove, William R. Birmingham, Juan Mangas-Sanchez, Joan Citoler, Matthew P. Thompson, Gao-Wei Zheng, Jian-He Xu, Nicholas J. Turner
Pubblicato in: ACS Catalysis, Numero 9/12, 2019, Pagina/e 11813-11818, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.9b03889

Biocatalytic Routes to Enantiomerically Enriched Dibenz[ c , e ]azepines

Autori: Scott P. France, Godwin A. Aleku, Mahima Sharma, Juan Mangas-Sanchez, Roger M. Howard, Jeremy Steflik, Rajesh Kumar, Ralph W. Adams, Iustina Slabu, Robert Crook, Gideon Grogan, Timothy W. Wallace, Nicholas J. Turner
Pubblicato in: Angewandte Chemie, Numero 129/49, 2017, Pagina/e 15795-15799, ISSN 0044-8249
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201708453

Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

Autori: Iustina Slabu, James L. Galman, Richard C. Lloyd, Nicholas J. Turner
Pubblicato in: ACS Catalysis, Numero 7/12, 2017, Pagina/e 8263-8284, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.7b02686

Bio-derived production of cinnamyl alcohol via a three step biocatalytic cascade and metabolic engineering

Autori: Evaldas Klumbys, Ziga Zebec, Nicholas J. Weise, Nicholas J. Turner, Nigel S. Scrutton
Pubblicato in: Green Chemistry, Numero 20/3, 2018, Pagina/e 658-663, ISSN 1463-9262
Editore: Royal Society of Chemistry
DOI: 10.1039/c7gc03325g

Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase

Autori: Godwin A. Aleku, Juan Mangas-Sanchez, Joan Citoler, Scott P. France, Sarah L. Montgomery, Rachel S. Heath, Matthew P. Thompson, Nicholas J. Turner
Pubblicato in: ChemCatChem, Numero 10/3, 2018, Pagina/e 515-519, ISSN 1867-3880
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201701484

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination

Autori: Scott P. France, Roger M. Howard, Jeremy Steflik, Nicholas J. Weise, Juan Mangas-Sanchez, Sarah L. Montgomery, Robert Crook, Rajesh Kumar, Nicholas J. Turner
Pubblicato in: ChemCatChem, Numero 10/3, 2018, Pagina/e 510-514, ISSN 1867-3880
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201701408

A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases

Autori: Mahima Sharma, Juan Mangas-Sanchez, Scott P. France, Godwin A. Aleku, Sarah L. Montgomery, Jeremy I. Ramsden, Nicholas J. Turner, Gideon Grogan
Pubblicato in: ACS Catalysis, Numero 8/12, 2018, Pagina/e 11534-11541, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.8b03491

Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships

Autori: Sarah L. Montgomery, Ahir Pushpanath, Rachel S. Heath, James R. Marshall, Ulrike Klemstein, James L. Galman, David Woodlock, Serena Bisagni, Christopher J. Taylor, J. Mangas-Sanchez, J. I. Ramsden, Beatriz Dominguez, Nicholas J. Turner
Pubblicato in: Science Advances, Numero 6/21, 2020, Pagina/e eaay9320, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.aay9320

Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases

Autori: Juan Mangas-Sanchez, Mahima Sharma, Sebastian C. Cosgrove, Jeremy I. Ramsden, James R. Marshall, Thomas W. Thorpe, Ryan B. Palmer, Gideon Grogan, Nicholas J. Turner
Pubblicato in: Chemical Science, Numero 11/19, 2020, Pagina/e 5052-5057, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc02253e

One-Step Biocatalytic Synthesis of Sustainable Surfactants by Selective Amide Bond Formation.

Autori: Max Lubberink; William Finnigan; Christian Schnepel; Christopher R. Baldwin; Nicholas J. Turner; Sabine L. Flitsch
Pubblicato in: Angewandte Chemie International Edition, Numero 61, 30, 2022, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202205054

RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades

Autori: William Finnigan, Lorna J. Hepworth, Sabine L. Flitsch, Nicholas J. Turner
Pubblicato in: Nature Catalysis, 2021, ISSN 2520-1158
Editore: Nature Publishing Group
DOI: 10.1038/s41929-020-00556-z

New Trends and Future Opportunities in the Enzymatic Formation of C-C, C-N, and C-O bonds.

Autori: Jack J. Sangster; James R. Marshall; Nicholas J. Turner; Juan Mangas-Sanchez
Pubblicato in: ChemBioChem, Numero 23, 6, 2022, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100464

One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines

Autori: Jack J. Sangster; Rebecca E. Ruscoe; Sebastian C. Cosgrove; Juan Mangas-Sánchez; Nicholas J. Turner
Pubblicato in: Journal of the American Chemical Society, Numero 145, 8, 2023, Pagina/e 4431–4437, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c09176

One-Pot Biocatalytic Synthesis of Substituted d-Tryptophans from Indoles Enabled by an Engineered Aminotransferase

Autori: Fabio Parmeggiani, Arnau Rué Casamajo, Curtis J. W. Walton, James L. Galman, Nicholas J. Turner, Roberto A. Chica
Pubblicato in: ACS Catalysis, 2019, Pagina/e 3482–3486, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.9b00739

Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades

Autori: Grayson J. Ford, Nico Kress, Ashley P. Mattey, Lorna J. Hepworth, Christopher R. Baldwin, James R. Marshall, Lisa S. Seibt, Min Huang, William R. Birmingham, Nicholas J. Turner, Sabine L. Flitsch
Pubblicato in: Chemical Communications, 2020, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cc02976a