Periodic Reporting for period 4 - TransFold (Molecular Biology of Nascent Chains: Co-translational folding and assembly of proteins in eukaryotes)
Período documentado: 2022-04-01 hasta 2023-03-31
Overall objectives of the project was to explore basic features and prevalence of co-translational protein assembly, how chaperones guide co-translational protein folding to affect assembly, whether translation of subunit-encoding mRNAs is spatially organized, and if so, how this occurs, and to what extent translation speed variations affect assembly. Studying the physical coupling of translation, folding and maturation will significantly advance our understanding of functional protein synthesis and provide a deeper understanding of the highly intricate organization of eukaryotic cells.