Role of individual retinal ganglion cell types in visual computation and behaviors

Informazioni relative al progetto

IndiVISUAL

ID dell’accordo di sovvenzione: 748332

DOI

10.3030/748332

Progetto concluso il 31 Agosto 2019

Data della firma CE 22 Febbraio 2017

Data di avvio 1 Settembre 2018

Data di completamento 31 Agosto 2020

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 212 194,80

Contributo UE

€ 212 194,80

Coordinato da

AARHUS UNIVERSITET
Denmark

Periodic Reporting for period 1 - IndiVISUAL (Role of individual retinal ganglion cell types in visual computation and behaviors)

Periodo di rendicontazione: 2018-09-01 al 2020-08-31

Sintesi del contesto e degli obiettivi generali del progetto

Problems assessed in current project aim to better understand vision at a single cell type resolution.
Besides contributing to better understanding of the circuit mechanism of vision, this could provide significant
insight on how visual impairment affects cell types of the retina.
Visual impairment affects approximately 26 million Europeans (WHO 2010), with significant numbers suffering from
unique cell type (Retinal ganglion cells) affecting illness like glaucoma
The overall objectives of the project aim to analyze the morphological and physiological function of individual retinal
cell types and to answer the question what is the role of an individual retinal ganglion cell type in visual computation and behaviour.
First we aim to characterize the morphological and physiological properties of Cre-labeled retinal ganglion cell types, this will provide the
tool-set needed. In the second phase aim to manipulate the activity of labeled ganglion cell types while observing central
processing and behavior, and to disseminate the findings.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

During the initial steps of the project, we are screening mouse lines for single cell type labeling, we look at cellular morphology and projections.
For the identified mouse lines experiments are currently performed for single cell type ablation. Once ablation is complete we will assess behavioral changes.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

This project aims to better understand what is the physiological function of retinal ganglion cell types affected during vision loss.
By the end of the project we aim to better understand how the large diversity of retina ganglion cell types integrate different visual stimuli,
and how they contribute to behaviour. This will not only benefit the field of basic research, but could potentially prove invaluable for developing better
treatments for retinal diseases.

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