Project description
Fatty liver and muscle loss in diabetes
Muscle atrophy refers to the loss of muscle mass, and it is a major problem for many patients with type 2 diabetes (T2D). Muscle atrophy has serious consequences for those patients as it results in poor physical performance and increased incidence of falls. Many patients with T2D have fat accumulation in the liver; previous studies have linked a fatty liver to the development of muscle atrophy, but the exact mechanisms are unknown. Funded by the Marie Skłodowska-Curie Actions programme, the LiSDMA project will explore how fat accumulation in the liver affects the liver secretory profile, and it will determine the impact of these secretion products on muscle protein metabolism. This innovative research will provide valuable insights into potential therapeutic strategies to combat muscle atrophy in patients with T2D.
Objective
Problem: Muscle atrophy is defined as a decrease in muscle mass, and is a major problem in many patients with type 2 diabetes (T2D). Previous studies have linked a fatty liver to the development of muscle atrophy in T2D patients, but the exact mechanisms are unknown. Background: Many T2D patients are characterised by hepatic steatosis. We have preliminary data to suggest that secretion products from the steatotic liver play an important role in the development of muscle atrophy. Aim: we will identify how hepatic steatosis affects the liver secretory profile, and we will determine the impact of these secretion products on muscle protein metabolism. We will also identify novel liver-secreted proteins that are causally related to muscle atrophy, and validate these proteins in patients with hepatic steatosis and T2D. Hypothesis: We hypothesize that hepatic steatosis changes the liver protein secretion profile which negatively impacts muscle mass. We also expect to identify proteins that are causally related to muscle atrophy, and to validate these proteins in patients with liver steatosis and T2D. Methods: We will use a translational approach in which leads from human studies will be investigated in cell- and animal experiments and subsequently tested again in human subjects. We will combine functional metabolic assays, high-throughput molecular biology approaches, cell biology and in vivo studies to investigate whether secretion products from the liver play a role in the development of muscle atrophy. Outcome: This project is the first to investigate whether secretion products from the liver directly contribute to the loss of muscle mass in T2D patients. Our research is innovative and will provide crucial proof-of-concept information to further develop therapeutic approaches to treat or prevent muscle atrophy in T2D patients.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-RI - RI – Reintegration panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6200 MD Maastricht
Netherlands
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