Objective
Animals interact with and respond to their environment by processing sensory inputs such as visual and auditory cues, touch, taste and smell. How an animal responds to sensory inputs however depends on its internal state (e.g. sleep, wakefulness, stress, fed or starved conditions), such that the same sensory input can produce different behaviours. Neuromodulators play an important role in mediating the internal state of the animal. Neuropeptide Y (NPY) and Gonadotropin-releasing hormone (GnRH) are neuropeptides that are conserved across vertebrates and modulate feeding and reproductive behaviours, antagonistically. They are produced by discrete neuronal populations, and are dispersed widely throughout the brain. Studies suggest that both GnRH/NPY modulate the basal olfactory response by altering the synaptic properties of olfactory receptor neurons. However, it is not known how GnRH/NPY influence the processing of chemosensory information in the olfactory bulb (OB) and ultimately odour driven behaviour. Here, I will use an optically transparent and genetically amenable vertebrate model, zebrafish to study brain function and behaviour. First, I will use genetic methods to specifically label, and visualise the activity of the GnRH/NPY neurons in response to natural odours ex vivo. Next, I will manipulate the activity of these neurons using optogenetics and by expressing neurotoxin/cell ablation genes, and study the effect on olfactory processing in the OB. Finally, after manipulating the activity of GnRH/NPY neurons, I will analyse the effect on odour driven behaviour. This will reveal the role of these neuromodulators in olfactory processing and hence on odour driven behaviour in vertebrates. This project unites my expertise in molecular genetics with that of my host in frontier neuroscience to address a fundamental question of sensory processing, relevant for understanding disorders in which behaviour is decoupled from internal state (e.g. obesity/anorexia).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine psychiatry obsessive-compulsive disorder
- medical and health sciences clinical medicine psychiatry posttraumatic stress disorder
- medical and health sciences clinical medicine psychiatry schizophrenia
- medical and health sciences basic medicine neurology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
7491 TRONDHEIM
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.