Objetivo What is the role of our microbial partners in our evolution? Does the microbiome evolution reflect major events of human history? Despite increasing evidence that the gut microbiome plays an essential role in multiple core aspects of human biology, little is known about how the human-gut community co-evolved. The role of the microbiome in human evolution and speciation has been historically overlooked, in part due to the challenge of obtaining microbiome data from ancient material. However, understanding the co-evolution of the human-gut ecosystem requires a time-series approach associated with the major defining moments in human evolution such as migrations, admixture, domestication, industrialization and globalisation. Under favourable conditions some archaeological substrates such mummified tissues, coprolites and dental calculus have potential to shed some light on ancient microbiomes. To do so, MIND THE GUT (MtG) will develop new markers of specific bacterial action applying lipidomic and proteomic tools to explore the diagenesis of microbiome substrates. MtG will analyze the mummified microbiomes of the aboriginal Canary islanders. The Canary mummies represent a unique model system to study the impact of diet and lifestyle in populations that evolved isolated but shared their microbiome during the peuplement of the islands. MtG will compare them with a group of naturally mummified bodies from Nubia that span a similar time period, and with modern microbiome samples from 3 african populations with different lifestyles. MtG results will provide a framework for future studies on fossil material and contribute to illuminate the role of the microbiome in overcoming the challenges of diet, environment and lifestyle changes that took place during human history and prehistory. MtG represents a stepping stone to the integration of the ancient microbiomes in the study of human evolution. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesevolutionary biologynatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsnatural sciencesbiological sciencesecologyecosystemsnatural sciencescomputer and information sciencesdata sciencedata processing Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2016 - Individual Fellowships Convocatoria de propuestas H2020-MSCA-IF-2016 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-GF - Global Fellowships Coordinador KOBENHAVNS UNIVERSITET Aportación neta de la UEn € 278 227,80 Dirección NORREGADE 10 1165 Kobenhavn Dinamarca Ver en el mapa Región Danmark Hovedstaden Byen København Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 278 227,80 Socios (1) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo Socio Las organizaciones asociadas contribuyen a la aplicación de la acción, pero no firman el acuerdo de subvención. MASSACHUSETTS INSTITUTE OF TECHNOLOGY Estados Unidos Aportación neta de la UEn € 0,00 Dirección MASSACHUSETTS AVENUE 77 02139 Cambridge Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 172 130,40