Objective
The specialised tissue architecture of the liver is crucially important for its essential metabolic functions in the body. The liver has the unique regenerative capacity to restore lost architecture when damaged. However, this remodelling process is compromised in chronic liver disease by scarring and cirrhosis. Often the only treatment is organ transplantation, thus the development of novel therapies is of vital importance. The necessary understanding of the dynamic cell rearrangement driving restoration of liver architecture has been limited by temporally static histological analyses of fixed regenerating tissue. Real-time monitoring of the mammalian liver is hindered by tissue opacity and deep organ position, whereas the surface location of the zebrafish liver and larval transparency makes this species uniquely suited for live, in vivo imaging of regeneration. LIVERZAP will generate a detailed map of the different cell behaviours driving restoration of liver architecture by pioneering real-time, in vivo imaging of regeneration in zebrafish. This will be achieved by: i) generating a novel, photoactivatable method for rapid hepatocyte ablation and ii) developing a deep tissue, 2-photon microscopy live imaging protocol. The molecular factors controlling the identified cell behaviours will be screened for using SILAC-based proteomics. To realise LIVERZAP, expertise in liver research, deep tissue microscopy and proteomics within the host environment will be combined with the fellow’s live imaging experience. LIVERZAP will generate excellent new tools for the regeneration community and greatly enhance the fellow’s competencies in specialised techniques, including cutting-edge microscopy systems and optogenetics. The outcomes of LIVERZAP will produce essential insights into the cellular and molecular mechanisms driving restoration of liver architecture following injury, providing a platform for the long-term development of therapies for human liver pathologies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine pathology
- medical and health sciences clinical medicine hepatology
- medical and health sciences clinical medicine embryology
- medical and health sciences clinical medicine gastroenterology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.