Proton CT reconstruction with a Cone Beam CT prior

Información del proyecto

protonCBCT

Identificador del acuerdo de subvención: 753370

DOI

10.3030/753370

Proyecto cerrado

Fecha de la firma de la CE 29 Marzo 2017

Fecha de inicio 1 Junio 2017

Fecha de finalización 31 Mayo 2019

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 185 076,00

Aportación de la UE

€ 185 076,00

Coordinado por

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Objetivo

"Proton therapy has become a superioralternative to conventional radiotherapy for certain clinical indications. It potentially allows to deliver high dose to the tumor while sparing healthy surrounding tissue. However, a reduction of treatment uncertainties is required to fully exploit this advantage and precise knowledge of the relative stopping power (RSP) of the patient tissues on the day of treatment is needed to correctly predict the proton range in the treatment planning system (TPS). Modern imaging technology plays a key role here.

Developing novel methods to produce volumetric images of the patient while positioned on the treatment couch lies at the heart of this proposal. More specifically, I propose to explore strategies to merge proton computed tomography (pCT) and cone beam CT (CBCT) acquired directly in the treatment room based on which accurate dose-of-the-day calculations can be performed. The idea arises from the complementary advantages of proton and X-ray imaging: The former potentially provides a highly accurate volumetric RSP map while the latter produces images of high spatial resolution.

I will develop and implement a ""protonCBCT"" reconstruction algorithm which uses the CBCT data as prior, compensates for image noise through dedicated regularization methods, and builds the pCT image using state-of-the-art reconstruction techniques. I emphasize the clinical applicability of the project: I will A) consider pCT and CBCT data acquired with clinically available imaging technology, B) propose a treatment work flow to incorporate the new protonCBCT imaging, and C) validate our methods using clinically proven treatment planning software.

To my knowledge, a combined pCT/CBCT imaging modality in a clinical context has not been studied yet. It has the potential of providing volumetric images with excellent quality acquired in situ directly prior to a treatment session and could eventually lead to higher treatment quality in proton therapy."

Ámbito científico (EuroSciVoc)

• ciencias naturales › informática y ciencias de la información › software
• ingeniería y tecnología › ingeniería médica › imagenología › tomografía axial computerizada
• ciencias naturales › ciencias físicas › óptica › microscopía

Programa(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions PROGRAMA PRINCIPAL
  
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
  

Tema(s)

• MSCA-IF-2016 - Individual Fellowships
  

Régimen de financiación

MSCA-IF-EF-ST - Standard EF

Convocatoria de propuestas

H2020-MSCA-IF-2016

Coordinador

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

• Aportación neta de la UEn: € 185 076,00
• Dirección: RUE MICHEL ANGE 3 ; 75794 PARIS ; Francia
• Tipo de actividad: Research Organisations
• Coste total: € 185 076,00