Periodic Reporting for period 1 - DNCSS (Decoding neural circuits controlling sleep drive and sedation)
Berichtszeitraum: 2018-09-01 bis 2020-08-31
This project aimed to identify novel neuronal circuits controlling sleep and sedation. Discoveries of this project would significantly advance our understanding of the fundamental mechanisms of sleep/sedation and provide novel insights into how sleep is linked with various neurological disorders. It would also offer potential therapeutic strategies and contribute to designing more efficient and safer medications.
The main scientific goal was broken down into the following three objectives:
- To evaluate alterations of excitatory/inhibitory input onto defined LPO neurons during prolonged wakefulness and sedation.
- To identify the origin of inputs onto the defined LPO neurons
- To determine the effects of altered connectivity involving active LPO neurons on sleep and sedation status in vivo.