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Testing the value of a novel strategic approach and its cost efficacy to improve the poor outcomes in Cardiogenic Shock

Objective

Heart attacks are common and can leave survivors suffering cardiogenic shock (CGS), with its extremely high risk of early death (42% versus 4% for non-CGS) and high incidence of chronic heart failure, with its associated socio-economic disease burden (ill-health, recurrent heart failure admissions, no return to full time activities, need for expensive therapeutic devices and life-long drugs). Outcomes from CGS are even worse in, females, the elderly (mortality>70%) and high risk sub-groups. The incidence of CGS in Europe alone is >50 000 patients pa. This unacceptably high mortality/morbidity rate represents a true unmet clinical need. No clear strategy exists to improve outcomes, with ad hoc therapies given too late in a spiralling, irrecoverable process.
EURO SHOCK aims to improve outcomes for CGS patients. At its core is a robust phase3 randomised trial comparing a novel strategy of very early use of ECMO (Extracorporeal Membrane Oxygenation) to current standard of care. Evidence suggests very early ECMO will halt the spiral of decline and so significantly reduce 12 month death rate and need for heart failure re-admissions. Since both costs of CGS, and ECMO are high a health-economic cost efficacy analysis will be core. A cardiac magnetic resonance imaging sub-study will test novel protocols in sick patients and provide mechanistic data. We will test transfer networks for CGS patients and analyse ECG data to determine which patients benefit most from early transfer.
Our multidisciplinary consortium comprises renowned physician-scientists, statisticians, health economists and technology providers, including specialised ECMO SME.
EURO SHOCK will impact on heart attack survivors, healthcare providers and Europe`s medical technology sector by 1) reducing healthcare costs associated with CGS 2) provide novel cost effective framework for cardiac interventions 3) delivering innovative healthcare technologies and 4) informing guidelines for effective CGS intervention.

Field of science

  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging
  • /social sciences/sociology/demography/mortality

Call for proposal

H2020-SC1-2017-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITY OF LEICESTER
Address
University Road
LE1 7RH Leicester
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 946 312

Participants (15)

DEUTSCHES HERZZENTRUM MUNCHEN
Germany
EU contribution
€ 252 500
Address
Lazarettstrasse 36
80636 Munich
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 1 327 843,50
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 517 400
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 252 500
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 360 812,50
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET

Participation ended

Norway
EU contribution
€ 14 496,25
Address
Hansine Hansens Veg 14
9019 Tromso
Activity type
Higher or Secondary Education Establishments
PAULA STRADINA KLINISKA UNIVERSITATES SLIMNICA
Latvia
EU contribution
€ 82 500
Address
Pilsonu Iela 13
1002 Riga
Activity type
Higher or Secondary Education Establishments
AZIENDA OSPEDALIERA PAPA GIOVANNI XXIII
Italy
EU contribution
€ 252 375
Address
Piazza Oms 1
24127 Bergamo
Activity type
Other
UNIVERSITAIR ZIEKENHUIS ANTWERPEN
Belgium
EU contribution
€ 252 500
Address
Wilrijkstraat 10
2650 Edegem
Activity type
Research Organisations
UNIVERSITY OF EAST ANGLIA
United Kingdom
EU contribution
€ 267 717,50
Address
Earlham Road
NR4 7TJ Norwich
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT POLITECNICA DE CATALUNYA
Spain
EU contribution
€ 148 440
Address
Calle Jordi Girona 31
08034 Barcelona
Activity type
Higher or Secondary Education Establishments
CHALICE MEDICAL LIMITED
United Kingdom
EU contribution
€ 793 750
Address
Unit 1-2 Draytonvourt Manton Road Wood. Entreprise Park. Worksop Nottinghamdhire
S80 2RS Worksop
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ACCELOPMENT AG
Switzerland
EU contribution
€ 421 171,88
Address
Seefeldstrasse 198
8008 Zuerich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRE EUROPEEN DE RECHERCHE CARDIOVASCULAIRE CERC
France
EU contribution
€ 320 000
Address
7 Rue Du Theatre
91300 Massy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITETSSYKEHUSET NORD-NORGE HF
Norway
EU contribution
€ 289 253,75
Address
Sykehusveien 38
9019 Tromso
Activity type
Research Organisations