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Testing the value of a novel strategic approach and its cost efficacy to improve the poor outcomes in Cardiogenic Shock

Objective

Heart attacks are common and can leave survivors suffering cardiogenic shock (CGS), with its extremely high risk of early death (42% versus 4% for non-CGS) and high incidence of chronic heart failure, with its associated socio-economic disease burden (ill-health, recurrent heart failure admissions, no return to full time activities, need for expensive therapeutic devices and life-long drugs). Outcomes from CGS are even worse in, females, the elderly (mortality>70%) and high risk sub-groups. The incidence of CGS in Europe alone is >50 000 patients pa. This unacceptably high mortality/morbidity rate represents a true unmet clinical need. No clear strategy exists to improve outcomes, with ad hoc therapies given too late in a spiralling, irrecoverable process.
EURO SHOCK aims to improve outcomes for CGS patients. At its core is a robust phase3 randomised trial comparing a novel strategy of very early use of ECMO (Extracorporeal Membrane Oxygenation) to current standard of care. Evidence suggests very early ECMO will halt the spiral of decline and so significantly reduce 12 month death rate and need for heart failure re-admissions. Since both costs of CGS, and ECMO are high a health-economic cost efficacy analysis will be core. A cardiac magnetic resonance imaging sub-study will test novel protocols in sick patients and provide mechanistic data. We will test transfer networks for CGS patients and analyse ECG data to determine which patients benefit most from early transfer.
Our multidisciplinary consortium comprises renowned physician-scientists, statisticians, health economists and technology providers, including specialised ECMO SME.
EURO SHOCK will impact on heart attack survivors, healthcare providers and Europe`s medical technology sector by 1) reducing healthcare costs associated with CGS 2) provide novel cost effective framework for cardiac interventions 3) delivering innovative healthcare technologies and 4) informing guidelines for effective CGS intervention.

Call for proposal

H2020-SC1-2016-2017

See other projects for this call

Sub call

H2020-SC1-2017-Two-Stage-RTD

Coordinator

UNIVERSITY OF LEICESTER
Net EU contribution
€ 886 312,00
Address
University Road
LE1 7RH Leicester
United Kingdom

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Region
East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicester
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,50

Participants (19)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST
United Kingdom
Net EU contribution
€ 60 000,00
Address
Infirmary Square Leicester Royal Infirmary Balmoral Building Level 3
LE1 5WW Leicester

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Region
East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicester
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
DEUTSCHES HERZZENTRUM MUNCHEN
Germany
Net EU contribution
€ 252 500,00
Address
Lazarettstrasse 36
80636 Munich

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITY OF GLASGOW
United Kingdom
Net EU contribution
€ 1 320 497,25
Address
University Avenue
G12 8QQ Glasgow

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Region
West Central Scotland Glasgow City
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

GREATER GLASGOW HEALTH BOARD
United Kingdom
Net EU contribution
€ 7 346,25
Address
Great Western Road 1055 J B Russell
G12 0XH Glasgow

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Region
West Central Scotland Glasgow City
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Net EU contribution
€ 517 400,00
Address
Oude Markt 13
3000 Leuven

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Net EU contribution
€ 252 500,00
Address
Geschwister Scholl Platz 1
80539 Muenchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
Net EU contribution
€ 290 812,50
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Other
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

HOSPITAL CLINIC DE BARCELONA
Spain
Net EU contribution
€ 70 000,00
Address
Calle Villarroel 170
08036 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET

Participation ended

Norway
Net EU contribution
€ 14 496,25
Address
Hansine Hansens Veg 14
9019 Tromso

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Region
Norge Nord-Norge Troms og Finnmark
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
PAULA STRADINA KLINISKA UNIVERSITATES SLIMNICA
Latvia
Net EU contribution
€ 82 500,00
Address
Pilsonu Iela 13
1002 Riga

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Region
Latvija Latvija Rīga
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AZIENDA OSPEDALIERA PAPA GIOVANNI XXIII
Italy
Net EU contribution
€ 107 375,00
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FONDAZIONE PER LA RICERCA OSPEDALE MAGGIORE DE BERGAMO
Italy
Net EU contribution
€ 145 000,00
Address
Largo Barozzi 1
24128 Bergamo

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Region
Nord-Ovest Lombardia Bergamo
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITAIR ZIEKENHUIS ANTWERPEN
Belgium
Net EU contribution
€ 252 500,00
Address
Drie Eikenstraat 655
2650 Edegem

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Region
Vlaams Gewest Prov. Antwerpen Arr. Antwerpen
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITY OF EAST ANGLIA
United Kingdom
Net EU contribution
€ 267 717,50
Address
Earlham Road
NR4 7TJ Norwich

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Region
East of England East Anglia Norwich and East Norfolk
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAT POLITECNICA DE CATALUNYA
Spain
Net EU contribution
€ 148 440,00
Address
Calle Jordi Girona 31
08034 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CHALICE MEDICAL LIMITED
United Kingdom
Net EU contribution
€ 793 750,00
Address
Unit 1-2 Draytonvourt Manton Road Wood. Entreprise Park. Worksop Nottinghamdhire
S80 2RS Worksop

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
East Midlands (England) Derbyshire and Nottinghamshire North Nottinghamshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ACCELOPMENT SCHWEIZ AG
Switzerland
Net EU contribution
€ 421 171,88
Address
Seefeldstrasse 198
8008 Zurich

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CENTRE EUROPEEN DE RECHERCHE CARDIOVASCULAIRE CERC
France
Net EU contribution
€ 320 000,00
Address
7 Rue Du Theatre
91300 Massy

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITETSSYKEHUSET NORD-NORGE HF
Norway
Net EU contribution
€ 289 253,75
Address
Sykehusveien 38
9019 Tromso

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Region
Norge Nord-Norge Troms og Finnmark
Activity type
Research Organisations
Non-EU contribution
€ 0,00