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Decomposing Heterogeneity in Autism Spectrum Disorders

Publicaciones

Prognostic early snapshot stratification of autism based on adaptive functioning

Autores: Veronica Mandelli, Isotta Landi, Elena Maria Busuoli, Eric Courchesne, Karen Pierce & Michael V. Lombardo
Publicado en: Nature Mental Health, Issue 1, 2023, Page(s) 327-336, ISSN 2731-6076
Editor: Springer Nature
DOI: 10.1038/s44220-023-00056-6

Pre-treatment clinical and gene expression patterns predict developmental change in early intervention in autism

Autores: Michael V. Lombardo, Elena Maria Busuoli, Laura Schreibman, Aubyn C. Stahmer, Tiziano Pramparo, Isotta Landi, Veronica Mandelli, Natasha Bertelsen, Cynthia Carter Barnes, Vahid Gazestani, Linda Lopez, Elizabeth C. Bacon, Eric Courchesne & Karen Pierce
Publicado en: Molecular Psychiatry, Issue 26, 2021, Page(s) 7641–7651, ISSN 1476-5578
Editor: Nature Publishing Group
DOI: 10.1038/s41380-021-01239-2

Neural responses to affective speech, including motherese, map onto clinical and social eye tracking profiles in toddlers with ASD

Autores: Yaqiong Xiao, Teresa H. Wen, Lauren Kupis, Lisa T. Eyler, Disha Goel, Keith Vaux, Michael V. Lombardo, Nathan E. Lewis, Karen Pierce, Eric Courchesne
Publicado en: Nature Human Behaviour, Issue 6, 2022, Page(s) 443-454, ISSN 2397-3374
Editor: Springer Nature
DOI: 10.1038/s41562-021-01237-y

Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry

Autores: Natasha Bertelsen, Isotta Landi, Richard A. I. Bethlehem, Jakob Seidlitz, Elena Maria Busuoli, Veronica Mandelli, Eleonora Satta, Stavros Trakoshis, Bonnie Auyeung, Prantik Kundu, Eva Loth, Guillaume Dumas, Sarah Baumeister, Christian F. Beckmann, Sven Bölte, Thomas Bourgeron, Tony Charman, Sarah Durston, Christine Ecker, Rosemary J. Holt, Mark H. Johnson, Emily J. H. Jones, Luke Mason, Andreas M
Publicado en: Communications Biology, Issue 4/1, 2021, ISSN 2399-3642
Editor: Springer Nature
DOI: 10.1038/s42003-021-02015-2

Prototyping as subtyping strategy for studying heterogeneity in autism.

Autores: Michael V. Lombardo; Michael V. Lombardo
Publicado en: Autism Research, Issue 14, 2021, Page(s) 2224-2227, ISSN 1939-3792
Editor: International Society for Autism Research
DOI: 10.1002/aur.2535

reval: A Python package to determine best clustering solutions with stability-based relative clustering validation

Autores: Isotta Landi, Veronica Mandelli, Michael V. Lombardo
Publicado en: Patterns, Issue 2/4, 2021, Page(s) 100228, ISSN 2666-3899
Editor: Cell Press
DOI: 10.1016/j.patter.2021.100228

Atypical genomic cortical patterning in autism with poor early language outcome

Autores: Lombardo, M. V., Eyler, L., Pramparo, T., Gazestani, V. H., Hagler, D. J., Chen, C.-H., Dale, A. M., Seidlitz, J., Bethlehem, R. A. I., Bertelsen, N., Carter Barnes, C., Lopez, L., Lewis, N. E., Pierce, K., & Courchesne, E.
Publicado en: Science Advances, Issue 7, 2021, Page(s) eabh1663, ISSN 2375-2548
Editor: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abh1663

Rethinking Our Concepts and Assumptions About Autism

Autores: Michael V Lombardo, Veronica Mandelli
Publicado en: Frontiers in Psychiatry, 2022, ISSN 1664-0640
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2022.903489

Sex-specific impact of prenatal androgens on social brain default mode subsystems

Autores: Michael V. Lombardo, Bonnie Auyeung, Tiziano Pramparo, Angélique Quartier, Jérémie Courraud, Rosemary J. Holt, Jack Waldman, Amber N. V. Ruigrok, Natasha Mooney, Richard A. I. Bethlehem, Meng-Chuan Lai, Prantik Kundu, Edward T. Bullmore, Jean-Louis Mandel, Amélie Piton, Simon Baron-Cohen
Publicado en: Molecular Psychiatry, 2019, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-018-0198-y

Big data approaches to decomposing heterogeneity across the autism spectrum

Autores: Michael V. Lombardo, Meng-Chuan Lai, Simon Baron-Cohen
Publicado en: Molecular Psychiatry, Issue 24, 2019, Page(s) 1435–1450, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-018-0321-0

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes

Autores: Michael V. Lombardo, Tiziano Pramparo, Vahid Gazestani, Varun Warrier, Richard A. I. Bethlehem, Cynthia Carter Barnes, Linda Lopez, Nathan E. Lewis, Lisa Eyler, Karen Pierce, Eric Courchesne
Publicado en: Nature Neuroscience, Issue 21/12, 2018, Page(s) 1680-1688, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-018-0281-3

Neural self-representation in autistic women and association with ‘compensatory camouflaging’

Autores: Meng-Chuan Lai, Michael V Lombardo, Bhismadev Chakrabarti, Amber NV Ruigrok, Edward T Bullmore, John Suckling, Bonnie Auyeung, Francesca Happé, Peter Szatmari, Simon Baron-Cohen, Anthony J Bailey, Patrick F Bolton, Sarah Carrington, Marco Catani, Michael C Craig, Eileen M Daly, Sean CL Deoni, Christine Ecker, Julian Henty, Peter Jezzard, Patrick Johnston, Derek K Jones, Anya Madden, Diane Mullins
Publicado en: Autism, Issue 23, 2018, Page(s) 136236131880715, ISSN 1362-3613
Editor: SAGE Publications
DOI: 10.1177/1362361318807159

The ASD Living Biology: from cell proliferation to clinical phenotype

Autores: Eric Courchesne, Tiziano Pramparo, Vahid H. Gazestani, Michael V. Lombardo, Karen Pierce, Nathan E. Lewis
Publicado en: Molecular Psychiatry, Issue 24/1, 2019, Page(s) 88-107, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-018-0056-y

Large-scale analyses of the relationship between sex, age and intelligence quotient heterogeneity and cortical morphometry in autism spectrum disorder

Autores: Saashi A. Bedford, Min Tae M. Park, Gabriel A. Devenyi, Stephanie Tullo, Jurgen Germann, Raihaan Patel, Evdokia Anagnostou, Simon Baron-Cohen, Edward T. Bullmore, Lindsay R. Chura, Michael C. Craig, Christine Ecker, Dorothea L. Floris, Rosemary J. Holt, Rhoshel Lenroot, Jason P. Lerch, Michael V. Lombardo, Declan G. M. Murphy, Armin Raznahan, Amber N. V. Ruigrok, Elizabeth Smith, Michael D. Spence
Publicado en: Molecular Psychiatry, 2019, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-019-0420-6

Default mode-visual network hypoconnectivity in an autism subtype with pronounced social visual engagement difficulties

Autores: Michael V Lombardo, Lisa Eyler, Adrienne Moore, Michael Datko, Cynthia Carter Barnes, Debra Cha, Eric Courchesne, Karen Pierce
Publicado en: eLife, Issue 8, 2019, Page(s) e47427, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.47427

Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

Autores: Stavros Trakoshis, Pablo Martínez-Cañada, Federico Rocchi, Carola Canella, Wonsang You, Bhismadev Chakrabarti, Amber NV Ruigrok, Edward T Bullmore, John Suckling, Marija Markicevic, Valerio Zerbi, Simon Baron-Cohen, Alessandro Gozzi, Meng-Chuan Lai, Stefano Panzeri, Michael V Lombardo
Publicado en: eLife, Issue 9, 2020, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.55684

The Link Between Autism and Sex-Related Neuroanatomy, and Associated Cognition and Gene Expression

Autores: Dorothea L. Floris, Han Peng, Varun Warrier, Michael V. Lombardo, Charlotte M. Pretzsch, Clara Moreau, Alex Tsompanidis, Weikang Gong, Maarten Mennes, Alberto Llera, Daan van Rooij, Marianne Oldehinkel, Natalie J. Forde, Tony Charman, Julian Tillmann, Tobias Banaschewski, Carolin Moessnang, Sarah Durston, Rosemary J. Holt, Christine Ecker, Flavio Dell’Acqua, Eva Loth, Thomas Bourgeron, Declan G.
Publicado en: American Journal of Psychiatry, Issue 180, 2023, Page(s) 50-64, ISSN 0002-953X
Editor: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220194

A normative modelling approach reveals age-atypical cortical thickness in a subgroup of males with autism spectrum disorder

Autores: Richard A. I. Bethlehem, Jakob Seidlitz, Rafael Romero-Garcia, Stavros Trakoshis, Guillaume Dumas, Michael V. Lombardo
Publicado en: Communications Biology, Issue 3, 2020, Page(s) 486, ISSN 2399-3642
Editor: Springer Nature
DOI: 10.1038/s42003-020-01212-9

mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity

Autores: Marco Pagani, Noemi Barsotti, Alice Bertero, Stavros Trakoshis, Laura Ulysse, Andrea Locarno, Ieva Miseviciute, Alessia De Felice, Carola Canella, Kaustubh Supekar, Alberto Galbusera, Vinod Menon, Raffaella Tonini, Gustavo Deco, Michael V. Lombardo, Massimo Pasqualetti, Alessandro Gozzi
Publicado en: Nature Communications, Issue 12, 2021, Page(s) 6084, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-26131-z

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