Objective
Nature has been employing attractive non-covalent interactions for billions of years to enable the chemical synthesis machinery of life that is enzymatic catalysis. In comparison, synthetic chemists have only very recently started to employ the very strongest, hydrogen bonds and ion pairs, to control selectivity in synthetic routes. This has occurred predominantly in the rapidly growing of enantioselective organocatalysis and has quickly had a huge impact. The vision of this grant is to take these insights and apply them to control of two more important aspects of selectivity facing the synthetic chemist – regioselectivity (positional selectivity within a particular functional group) and site-selectivity (within a wider molecule). These selectivity aspects are particularly relevant due to the increasing number of methods for functionalisation of C-H bonds, in which the overarching challenge is obtaining selectivity for one in the presence of many.
My plan to achieve this will be divided into three main parts:
WP1. We will combine reactive and versatile transition metals with bespoke ligands which will interact with a common functional group in the substrate via a key non-covalent interaction. The resulting functionalisation of the substrate will be rendered pseudointramolecular, permitting regioselectivity or site-selectivity to be controlled through judicious catalyst design.
WP2. We will develop novel catalytic strategies to control the selectivity of intermolecular radical reactions. In radical chemistry, whilst reactivity is often high, low selectivity is often the limiting factor and as such often the most selective radical reactions are intramolecular ones. By intramolecularising radical reactions by the use of temporary non-covalent interactions we will solve outstanding problems in aromatic and aliphatic radical C-H functionalisation.
WP3. The methods developed above will be applied to the late-stage functionalisation of pharmaceutically relevant molecules
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2017-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.