Harnessing Non-Covalent Interactions for Control of Regioselectivity and Site-Selectivity in Catalysis

Project Information

NonCovRegioSiteCat

Grant agreement ID: 757381

DOI

10.3030/757381

Project closed

EC signature date 9 October 2017

Start date 1 January 2018

End date 30 September 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 756,00

EU contribution

€ 1 499 756,00

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (26)

A Computational and Experimental Investigation of the Origin of Selectivity in the Chiral Phosphoric Acid Catalyzed Enantioselective Minisci Reaction

Author(s): Kristaps Ermanis, Avene C. Colgan, Rupert S. J. Proctor, Barbara W. Hadrys, Robert J. Phipps, Jonathan M. Goodman
Published in: Journal of the American Chemical Society, Issue 142/50, 2020, Page(s) 21091-21101, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c09668

Recent Advances in Minisci‐Type Reactions

Author(s): Rupert S. J. Proctor, Robert J. Phipps
Published in: Angewandte Chemie International Edition, Issue 58/39, 2019, Page(s) 13666-13699, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201900977

Hydrogen Atom Transfer-Driven Enantioselective Minisci Reaction of Amides

Author(s): Rupert S. J. Proctor, Padon Chuentragool, Avene C. Colgan, Robert J. Phipps
Published in: Journal of the American Chemical Society, Issue 143/13, 2021, Page(s) 4928-4934, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c01556

Enantioselective Giese Additions of Prochiral α-Amino Radicals

Author(s): Antti S. K. Lahdenperä; P. David Bacoş; Robert J. Phipps
Published in: Journal of the American Chemical Society, Issue 144, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c11367

Regioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines

Author(s): James E. Gillespie, Charlotte Morrill, and Robert J. Phipps
Published in: Journal of the American Chemical Society, 2021, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c05531

An Aminative Rearrangement of O-(Arenesulfonyl)hydroxylamines: Facile Access to ortho-Sulfonyl Anilines

Author(s): Charlotte Morrill; James E. Gillespie; Robert J. Phipps
Published in: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202204025

Substrate-Directed Enantioselective Aziridination of Alkenyl Alcohols Controlled by a Chiral Cation

Author(s): Alexander Fanourakis; Nicholas J. Hodson; Arthur R. Lit; Robert J. Phipps
Published in: Journal of the American Chemical Society, Issue 145, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c00693

Ortho-Selective amination of arene carboxylic acids via rearrangement of acyl O-hydroxylamines

Author(s): James E. Gillespie; Nelson Y. S. Lam; Robert J. Phipps
Published in: Chemical Science, Issue 14, 2023, ISSN 2041-6539
Publisher: RSC
DOI: 10.1039/d3sc03293k

Interrogating the Crucial Interactions at Play in the Chiral Cation-Directed Enantioselective Borylation of Arenes

Author(s): Kristaps Ermanis; David C. Gibson; Georgi R. Genov; Robert J. Phipps
Published in: ACS Catalysis, Issue 13, 2023, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.3c03384

An Enantioselective Suzuki–Miyaura Coupling To Form Axially Chiral Biphenols

Author(s): Robert Pearce-Higgins; Larissa N. Hogenhout; Philip J. Docherty; David M. Whalley; Padon Chuentragool; Najung Lee; Nelson Y. S. Lam; Thomas M. McGuire; Damien Valette; Robert J. Phipps
Published in: Journal of the American Chemical Society, Issue 144, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c06529

sSPhos: A General Ligand for Enantioselective Arylative Phenol Dearomatization via Electrostatically-Directed Palladium Catalysis

Author(s): Max Kadarauch; David M. Whalley; Robert J. Phipps
Published in: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c10663

Tertiary Amides as Directing Groups for Enantioselective C−H Amination using Ion-Paired Rhodium Complexes

Author(s): Kieran J. Paterson, Amit Dahiya, Benjamin D. Williams, Robert J. Phipps
Published in: Angewandte Chemie International Edition, 2024, Page(s) e202317489, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202317489

Strategies That Utilize Ion Pairing Interactions to Exert Selectivity Control in the Functionalization of C–H Bonds

Author(s): James E. Gillespie; Alexander Fanourakis; Robert J. Phipps
Published in: Journal of the American Chemical Society, Issue 144, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c08752

Catalytic, asymmetric carbon–nitrogen bond formation using metal nitrenoids: from metal–ligand complexes via metalloporphyrins to enzymes

Author(s): Alexander Fanourakis; Robert J. Phipps
Published in: Chemical Science, 2023, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc04661c

Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates

Author(s): Rupert S. J. Proctor, Avene C. Colgan, Robert J. Phipps
Published in: Nature Chemistry, Issue 12/11, 2020, Page(s) 990-1004, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-020-00561-6

Ion-Pair-Directed Borylation of Aromatic Phosphonium Salts

Author(s): Bernadette Lee, Madalina T. Mihai, Violeta Stojalnikova, Robert J. Phipps
Published in: The Journal of Organic Chemistry, Issue 84, 2019, Page(s) 13124-13134, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.9b00878

Site-Selective Cross-Coupling of Remote Chlorides Enabled by Electrostatically Directed Palladium Catalysis

Author(s): William A. Golding, Robert Pearce-Higgins, Robert J. Phipps
Published in: Journal of the American Chemical Society, Issue 140/42, 2018, Page(s) 13570-13574, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.8b08686

Para-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation

Author(s): Madalina T. Mihai, Benjamin D. Williams, Robert J Phipps
Published in: Journal of the American Chemical Society, Issue 141, 2019, Page(s) 15477-15482, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b07267

Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines

Author(s): Jolene P. Reid, Rupert S. J. Proctor, Matthew S. Sigman, Robert J. Phipps
Published in: Journal of the American Chemical Society, Issue 141/48, 2019, Page(s) 19178-19185, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b11658

Electrostatically-directed Pd-catalysis in combination with C–H activation: site-selective coupling of remote chlorides with fluoroarenes and fluoroheteroarenes

Author(s): William A. Golding, Robert J. Phipps
Published in: Chemical Science, Issue 11/11, 2020, Page(s) 3022-3027, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc00105h

Enantioselective remote C–H activation directed by a chiral cation

Author(s): Georgi R. Genov, James L. Douthwaite, Antti S. K. Lahdenperä, David C. Gibson, Robert J. Phipps
Published in: Science, Issue 367/6483, 2020, Page(s) 1246-1251, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aba1120

Hydrogen Atom Transfer Driven Enantioselective Minisci Reaction of Alcohols

Author(s): Dr. Avene C. Colgan, Dr. Rupert S. J. Proctor, David C. Gibson, Dr. Padon Chuentragool, Dr. Antti S. K. Lahdenperä, Dr. Kristaps Ermanis, Dr. Robert J. Phipps
Published in: Angewandte Chemie Int Ed, Issue 61, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202200266

Enantioselective Intermolecular C–H Amination Directed by a Chiral Cation

Author(s): Alexander Fanourakis; Benjamin D. Williams; Kieran J. Paterson; Robert J. Phipps
Published in: Journal of the American Chemical Society, Issue 143, 2021, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c05206

Systematic Variation of Ligand and Cation Parameters Enables Site-Selective C–C and C–N Cross-Coupling of Multiply Chlorinated Arenes through Substrate–Ligand Electrostatic Interactions

Author(s): William A. Golding, Hendrik L. Schmitt, Robert J. Phipps
Published in: Journal of the American Chemical Society, Issue 142/52, 2020, Page(s) 21891-21898, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c11056

Discovery and Development of the Enantioselective Minisci Reaction

Author(s): P. David Bacoş; Antti S. K. Lahdenpera; Robert J. Phipps
Published in: Accounts of Chemical Research, Issue 56, 2023, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.3c00247

Recent Developments in Enantioselective Transition Metal Catalysis Featuring Attractive Noncovalent Interactions between Ligand and Substrate

Author(s): Alexander Fanourakis, Philip J. Docherty, Padon Chuentragool, Robert J. Phipps
Published in: ACS Catalysis, Issue 10/18, 2020, Page(s) 10672-10714, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.0c02957