Harnessing Non-Covalent Interactions for Control of Regioselectivity and Site-Selectivity in Catalysis

Información del proyecto

NonCovRegioSiteCat

Identificador del acuerdo de subvención: 757381

DOI

10.3030/757381

Proyecto cerrado

Fecha de la firma de la CE 9 Octubre 2017

Fecha de inicio 1 Enero 2018

Fecha de finalización 30 Septiembre 2023

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 499 756,00

Aportación de la UE

€ 1 499 756,00

Coordinado por

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (26)

A Computational and Experimental Investigation of the Origin of Selectivity in the Chiral Phosphoric Acid Catalyzed Enantioselective Minisci Reaction

Autores: Kristaps Ermanis, Avene C. Colgan, Rupert S. J. Proctor, Barbara W. Hadrys, Robert J. Phipps, Jonathan M. Goodman
Publicado en: Journal of the American Chemical Society, Edición 142/50, 2020, Página(s) 21091-21101, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.0c09668

Recent Advances in Minisci‐Type Reactions

Autores: Rupert S. J. Proctor, Robert J. Phipps
Publicado en: Angewandte Chemie International Edition, Edición 58/39, 2019, Página(s) 13666-13699, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201900977

Hydrogen Atom Transfer-Driven Enantioselective Minisci Reaction of Amides

Autores: Rupert S. J. Proctor, Padon Chuentragool, Avene C. Colgan, Robert J. Phipps
Publicado en: Journal of the American Chemical Society, Edición 143/13, 2021, Página(s) 4928-4934, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.1c01556

Enantioselective Giese Additions of Prochiral α-Amino Radicals

Autores: Antti S. K. Lahdenperä; P. David Bacoş; Robert J. Phipps
Publicado en: Journal of the American Chemical Society, Edición 144, 2022, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.2c11367

Regioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines

Autores: James E. Gillespie, Charlotte Morrill, and Robert J. Phipps
Publicado en: Journal of the American Chemical Society, 2021, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.1c05531

An Aminative Rearrangement of O-(Arenesulfonyl)hydroxylamines: Facile Access to ortho-Sulfonyl Anilines

Autores: Charlotte Morrill; James E. Gillespie; Robert J. Phipps
Publicado en: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202204025

Substrate-Directed Enantioselective Aziridination of Alkenyl Alcohols Controlled by a Chiral Cation

Autores: Alexander Fanourakis; Nicholas J. Hodson; Arthur R. Lit; Robert J. Phipps
Publicado en: Journal of the American Chemical Society, Edición 145, 2023, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.3c00693

Ortho-Selective amination of arene carboxylic acids via rearrangement of acyl O-hydroxylamines

Autores: James E. Gillespie; Nelson Y. S. Lam; Robert J. Phipps
Publicado en: Chemical Science, Edición 14, 2023, ISSN 2041-6539
Editor: RSC
DOI: 10.1039/d3sc03293k

Interrogating the Crucial Interactions at Play in the Chiral Cation-Directed Enantioselective Borylation of Arenes

Autores: Kristaps Ermanis; David C. Gibson; Georgi R. Genov; Robert J. Phipps
Publicado en: ACS Catalysis, Edición 13, 2023, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.3c03384

An Enantioselective Suzuki–Miyaura Coupling To Form Axially Chiral Biphenols

Autores: Robert Pearce-Higgins; Larissa N. Hogenhout; Philip J. Docherty; David M. Whalley; Padon Chuentragool; Najung Lee; Nelson Y. S. Lam; Thomas M. McGuire; Damien Valette; Robert J. Phipps
Publicado en: Journal of the American Chemical Society, Edición 144, 2022, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.2c06529

sSPhos: A General Ligand for Enantioselective Arylative Phenol Dearomatization via Electrostatically-Directed Palladium Catalysis

Autores: Max Kadarauch; David M. Whalley; Robert J. Phipps
Publicado en: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.3c10663

Tertiary Amides as Directing Groups for Enantioselective C−H Amination using Ion-Paired Rhodium Complexes

Autores: Kieran J. Paterson, Amit Dahiya, Benjamin D. Williams, Robert J. Phipps
Publicado en: Angewandte Chemie International Edition, 2024, Página(s) e202317489, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202317489

Strategies That Utilize Ion Pairing Interactions to Exert Selectivity Control in the Functionalization of C–H Bonds

Autores: James E. Gillespie; Alexander Fanourakis; Robert J. Phipps
Publicado en: Journal of the American Chemical Society, Edición 144, 2022, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.2c08752

Catalytic, asymmetric carbon–nitrogen bond formation using metal nitrenoids: from metal–ligand complexes via metalloporphyrins to enzymes

Autores: Alexander Fanourakis; Robert J. Phipps
Publicado en: Chemical Science, 2023, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d3sc04661c

Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates

Autores: Rupert S. J. Proctor, Avene C. Colgan, Robert J. Phipps
Publicado en: Nature Chemistry, Edición 12/11, 2020, Página(s) 990-1004, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-020-00561-6

Ion-Pair-Directed Borylation of Aromatic Phosphonium Salts

Autores: Bernadette Lee, Madalina T. Mihai, Violeta Stojalnikova, Robert J. Phipps
Publicado en: The Journal of Organic Chemistry, Edición 84, 2019, Página(s) 13124-13134, ISSN 0022-3263
Editor: American Chemical Society
DOI: 10.1021/acs.joc.9b00878

Site-Selective Cross-Coupling of Remote Chlorides Enabled by Electrostatically Directed Palladium Catalysis

Autores: William A. Golding, Robert Pearce-Higgins, Robert J. Phipps
Publicado en: Journal of the American Chemical Society, Edición 140/42, 2018, Página(s) 13570-13574, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.8b08686

Para-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation

Autores: Madalina T. Mihai, Benjamin D. Williams, Robert J Phipps
Publicado en: Journal of the American Chemical Society, Edición 141, 2019, Página(s) 15477-15482, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.9b07267

Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines

Autores: Jolene P. Reid, Rupert S. J. Proctor, Matthew S. Sigman, Robert J. Phipps
Publicado en: Journal of the American Chemical Society, Edición 141/48, 2019, Página(s) 19178-19185, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.9b11658

Electrostatically-directed Pd-catalysis in combination with C–H activation: site-selective coupling of remote chlorides with fluoroarenes and fluoroheteroarenes

Autores: William A. Golding, Robert J. Phipps
Publicado en: Chemical Science, Edición 11/11, 2020, Página(s) 3022-3027, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d0sc00105h

Enantioselective remote C–H activation directed by a chiral cation

Autores: Georgi R. Genov, James L. Douthwaite, Antti S. K. Lahdenperä, David C. Gibson, Robert J. Phipps
Publicado en: Science, Edición 367/6483, 2020, Página(s) 1246-1251, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aba1120

Hydrogen Atom Transfer Driven Enantioselective Minisci Reaction of Alcohols

Autores: Dr. Avene C. Colgan, Dr. Rupert S. J. Proctor, David C. Gibson, Dr. Padon Chuentragool, Dr. Antti S. K. Lahdenperä, Dr. Kristaps Ermanis, Dr. Robert J. Phipps
Publicado en: Angewandte Chemie Int Ed, Edición 61, 2022, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202200266

Enantioselective Intermolecular C–H Amination Directed by a Chiral Cation

Autores: Alexander Fanourakis; Benjamin D. Williams; Kieran J. Paterson; Robert J. Phipps
Publicado en: Journal of the American Chemical Society, Edición 143, 2021, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.1c05206

Systematic Variation of Ligand and Cation Parameters Enables Site-Selective C–C and C–N Cross-Coupling of Multiply Chlorinated Arenes through Substrate–Ligand Electrostatic Interactions

Autores: William A. Golding, Hendrik L. Schmitt, Robert J. Phipps
Publicado en: Journal of the American Chemical Society, Edición 142/52, 2020, Página(s) 21891-21898, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.0c11056

Discovery and Development of the Enantioselective Minisci Reaction

Autores: P. David Bacoş; Antti S. K. Lahdenpera; Robert J. Phipps
Publicado en: Accounts of Chemical Research, Edición 56, 2023, ISSN 0001-4842
Editor: American Chemical Society
DOI: 10.1021/acs.accounts.3c00247

Recent Developments in Enantioselective Transition Metal Catalysis Featuring Attractive Noncovalent Interactions between Ligand and Substrate

Autores: Alexander Fanourakis, Philip J. Docherty, Padon Chuentragool, Robert J. Phipps
Publicado en: ACS Catalysis, Edición 10/18, 2020, Página(s) 10672-10714, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.0c02957