Harnessing Non-Covalent Interactions for Control of Regioselectivity and Site-Selectivity in Catalysis

Informazioni relative al progetto

NonCovRegioSiteCat

ID dell’accordo di sovvenzione: 757381

DOI

10.3030/757381

Progetto chiuso

Data della firma CE 9 Ottobre 2017

Data di avvio 1 Gennaio 2018

Data di completamento 30 Settembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 499 756,00

Contributo UE

€ 1 499 756,00

Coordinato da

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (26)

A Computational and Experimental Investigation of the Origin of Selectivity in the Chiral Phosphoric Acid Catalyzed Enantioselective Minisci Reaction

Autori: Kristaps Ermanis, Avene C. Colgan, Rupert S. J. Proctor, Barbara W. Hadrys, Robert J. Phipps, Jonathan M. Goodman
Pubblicato in: Journal of the American Chemical Society, Numero 142/50, 2020, Pagina/e 21091-21101, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c09668

Recent Advances in Minisci‐Type Reactions

Autori: Rupert S. J. Proctor, Robert J. Phipps
Pubblicato in: Angewandte Chemie International Edition, Numero 58/39, 2019, Pagina/e 13666-13699, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201900977

Hydrogen Atom Transfer-Driven Enantioselective Minisci Reaction of Amides

Autori: Rupert S. J. Proctor, Padon Chuentragool, Avene C. Colgan, Robert J. Phipps
Pubblicato in: Journal of the American Chemical Society, Numero 143/13, 2021, Pagina/e 4928-4934, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.1c01556

Enantioselective Giese Additions of Prochiral α-Amino Radicals

Autori: Antti S. K. Lahdenperä; P. David Bacoş; Robert J. Phipps
Pubblicato in: Journal of the American Chemical Society, Numero 144, 2022, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c11367

Regioselective Radical Arene Amination for the Concise Synthesis of ortho-Phenylenediamines

Autori: James E. Gillespie, Charlotte Morrill, and Robert J. Phipps
Pubblicato in: Journal of the American Chemical Society, 2021, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.1c05531

An Aminative Rearrangement of O-(Arenesulfonyl)hydroxylamines: Facile Access to ortho-Sulfonyl Anilines

Autori: Charlotte Morrill; James E. Gillespie; Robert J. Phipps
Pubblicato in: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202204025

Substrate-Directed Enantioselective Aziridination of Alkenyl Alcohols Controlled by a Chiral Cation

Autori: Alexander Fanourakis; Nicholas J. Hodson; Arthur R. Lit; Robert J. Phipps
Pubblicato in: Journal of the American Chemical Society, Numero 145, 2023, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c00693

Ortho-Selective amination of arene carboxylic acids via rearrangement of acyl O-hydroxylamines

Autori: James E. Gillespie; Nelson Y. S. Lam; Robert J. Phipps
Pubblicato in: Chemical Science, Numero 14, 2023, ISSN 2041-6539
Editore: RSC
DOI: 10.1039/d3sc03293k

Interrogating the Crucial Interactions at Play in the Chiral Cation-Directed Enantioselective Borylation of Arenes

Autori: Kristaps Ermanis; David C. Gibson; Georgi R. Genov; Robert J. Phipps
Pubblicato in: ACS Catalysis, Numero 13, 2023, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.3c03384

An Enantioselective Suzuki–Miyaura Coupling To Form Axially Chiral Biphenols

Autori: Robert Pearce-Higgins; Larissa N. Hogenhout; Philip J. Docherty; David M. Whalley; Padon Chuentragool; Najung Lee; Nelson Y. S. Lam; Thomas M. McGuire; Damien Valette; Robert J. Phipps
Pubblicato in: Journal of the American Chemical Society, Numero 144, 2022, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c06529

sSPhos: A General Ligand for Enantioselective Arylative Phenol Dearomatization via Electrostatically-Directed Palladium Catalysis

Autori: Max Kadarauch; David M. Whalley; Robert J. Phipps
Pubblicato in: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c10663

Tertiary Amides as Directing Groups for Enantioselective C−H Amination using Ion-Paired Rhodium Complexes

Autori: Kieran J. Paterson, Amit Dahiya, Benjamin D. Williams, Robert J. Phipps
Pubblicato in: Angewandte Chemie International Edition, 2024, Pagina/e e202317489, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202317489

Strategies That Utilize Ion Pairing Interactions to Exert Selectivity Control in the Functionalization of C–H Bonds

Autori: James E. Gillespie; Alexander Fanourakis; Robert J. Phipps
Pubblicato in: Journal of the American Chemical Society, Numero 144, 2022, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c08752

Catalytic, asymmetric carbon–nitrogen bond formation using metal nitrenoids: from metal–ligand complexes via metalloporphyrins to enzymes

Autori: Alexander Fanourakis; Robert J. Phipps
Pubblicato in: Chemical Science, 2023, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d3sc04661c

Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates

Autori: Rupert S. J. Proctor, Avene C. Colgan, Robert J. Phipps
Pubblicato in: Nature Chemistry, Numero 12/11, 2020, Pagina/e 990-1004, ISSN 1755-4330
Editore: Nature Publishing Group
DOI: 10.1038/s41557-020-00561-6

Ion-Pair-Directed Borylation of Aromatic Phosphonium Salts

Autori: Bernadette Lee, Madalina T. Mihai, Violeta Stojalnikova, Robert J. Phipps
Pubblicato in: The Journal of Organic Chemistry, Numero 84, 2019, Pagina/e 13124-13134, ISSN 0022-3263
Editore: American Chemical Society
DOI: 10.1021/acs.joc.9b00878

Site-Selective Cross-Coupling of Remote Chlorides Enabled by Electrostatically Directed Palladium Catalysis

Autori: William A. Golding, Robert Pearce-Higgins, Robert J. Phipps
Pubblicato in: Journal of the American Chemical Society, Numero 140/42, 2018, Pagina/e 13570-13574, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.8b08686

Para-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation

Autori: Madalina T. Mihai, Benjamin D. Williams, Robert J Phipps
Pubblicato in: Journal of the American Chemical Society, Numero 141, 2019, Pagina/e 15477-15482, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.9b07267

Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines

Autori: Jolene P. Reid, Rupert S. J. Proctor, Matthew S. Sigman, Robert J. Phipps
Pubblicato in: Journal of the American Chemical Society, Numero 141/48, 2019, Pagina/e 19178-19185, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.9b11658

Electrostatically-directed Pd-catalysis in combination with C–H activation: site-selective coupling of remote chlorides with fluoroarenes and fluoroheteroarenes

Autori: William A. Golding, Robert J. Phipps
Pubblicato in: Chemical Science, Numero 11/11, 2020, Pagina/e 3022-3027, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc00105h

Enantioselective remote C–H activation directed by a chiral cation

Autori: Georgi R. Genov, James L. Douthwaite, Antti S. K. Lahdenperä, David C. Gibson, Robert J. Phipps
Pubblicato in: Science, Numero 367/6483, 2020, Pagina/e 1246-1251, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aba1120

Hydrogen Atom Transfer Driven Enantioselective Minisci Reaction of Alcohols

Autori: Dr. Avene C. Colgan, Dr. Rupert S. J. Proctor, David C. Gibson, Dr. Padon Chuentragool, Dr. Antti S. K. Lahdenperä, Dr. Kristaps Ermanis, Dr. Robert J. Phipps
Pubblicato in: Angewandte Chemie Int Ed, Numero 61, 2022, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202200266

Enantioselective Intermolecular C–H Amination Directed by a Chiral Cation

Autori: Alexander Fanourakis; Benjamin D. Williams; Kieran J. Paterson; Robert J. Phipps
Pubblicato in: Journal of the American Chemical Society, Numero 143, 2021, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.1c05206

Systematic Variation of Ligand and Cation Parameters Enables Site-Selective C–C and C–N Cross-Coupling of Multiply Chlorinated Arenes through Substrate–Ligand Electrostatic Interactions

Autori: William A. Golding, Hendrik L. Schmitt, Robert J. Phipps
Pubblicato in: Journal of the American Chemical Society, Numero 142/52, 2020, Pagina/e 21891-21898, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c11056

Discovery and Development of the Enantioselective Minisci Reaction

Autori: P. David Bacoş; Antti S. K. Lahdenpera; Robert J. Phipps
Pubblicato in: Accounts of Chemical Research, Numero 56, 2023, ISSN 0001-4842
Editore: American Chemical Society
DOI: 10.1021/acs.accounts.3c00247

Recent Developments in Enantioselective Transition Metal Catalysis Featuring Attractive Noncovalent Interactions between Ligand and Substrate

Autori: Alexander Fanourakis, Philip J. Docherty, Padon Chuentragool, Robert J. Phipps
Pubblicato in: ACS Catalysis, Numero 10/18, 2020, Pagina/e 10672-10714, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.0c02957