Deciphering the transport mechanisms of small xenobiotic molecules in synthetic yeast cell factories

Información del proyecto

YEAST-TRANS

Identificador del acuerdo de subvención: 757384

DOI

10.3030/757384

Proyecto cerrado

Fecha de la firma de la CE 27 Octubre 2017

Fecha de inicio 1 Diciembre 2017

Fecha de finalización 30 Noviembre 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 423 357,50

Aportación de la UE

€ 1 423 357,50

Coordinado por

DANMARKS TEKNISKE UNIVERSITET
Denmark

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan

The data management plan will address following issues: 1. Making data findable, 2. Making data openly Accessible, 3. Making data Interoperable, 4. Increase data Re-use, 5. Allocation of recourses and data security The data management plan will also specify if certain datasets remain closed and the reasons for not giving access will be given.

Publicaciones

Peer reviewed articles (26)

Rational and evolutionary engineering of Saccharomyces cerevisiae for production of dicarboxylic acids from lignocellulosic biomass and exploring genetic mechanisms of the yeast tolerance to the biomass hydrolysate

Autores: Vratislav Stovicek; Laura Dato; Henrik Almqvist; Marie Schöpping; Ksenia Chekina; Lasse Ebdrup Pedersen; Anna Koza; Diogo Figueira; Freddy Tjosås; Bruno Sommer Ferreira; Jochen Forster; Gunnar Lidén; Irina Borodina
Publicado en: Crossref, Edición 1, 2022, ISSN 2731-3654
Editor: Biotechnology for Biofuels and Bioproducts
DOI: 10.1186/s13068-022-02121-1

Engineering Yeast Yarrowia lipolytica for Methanol Assimilation.

Autores: Guokun Wang; Guokun Wang; Mattis Olofsson-Dolk; Frederik Gleerup Hansson; Stefano Donati; Xiaolin Li; Hong Chang; Jian Cheng; Jonathan Dahlin; Irina Borodina
Publicado en: ACS Synthetic Biology, Edición 1, 2021, ISSN 2161-5063
Editor: American Chemical Society
DOI: 10.1021/acssynbio.1c00464

Metabolic Engineering of Saccharomyces cerevisiae for Rosmarinic Acid Production

Autores: Mahsa Babaei, Gheorghe M. Borja Zamfir, Xiao Chen, Hanne Bjerre Christensen, Mette Kristensen, Jens Nielsen, Irina Borodina
Publicado en: ACS Synthetic Biology, Edición 9/8, 2020, Página(s) 1978-1988, ISSN 2161-5063
Editor: American Chemical Society
DOI: 10.1021/acssynbio.0c00048

Production of abscisic acid in the oleaginous yeast <i>Yarrowia lipolytica</i>

Autores: Jonathan Asmund Arnesen; Irene Hjorth Jacobsen; Jane Dannow Dyekjær; Daniela Rago; Mette Kristensen; Andreas Koedfoed Klitgaard; Milica Randelovic; José Luis Martinez; Irina Borodina
Publicado en: Crossref, Edición 1, 2022, ISSN 1567-1364
Editor: Oxford University press
DOI: 10.1093/femsyr/foac015

Modulation of the cell wall protein Ecm33p in yeast <i>Saccharomyces cerevisiae</i> improves the production of small metabolites

Autores: Verónica Ramos-Viana; Iben Møller-Hansen; Paul Kempen; Irina Borodina
Publicado en: FEMS Yeast Research, Edición 1, 2022, Página(s) foac037, ISSN 1567-1356
Editor: Blackwell
DOI: 10.1093/femsyr/foac037

Efficient biodegradation of aliphatic polyester by genetically engineered strains of the yeast Yarrowia lipolytica

Autores: Katarzyna E. Kosiorowska; Xymena Połomska; Guokun Wang; Irina Borodina; Aleksandra M. Mirończuk
Publicado en: International Biodeterioration and Biodegradation, Edición 1, 2021, Página(s) 105232, ISSN 0964-8305
Editor: Elsevier BV
DOI: 10.1016/j.ibiod.2021.105232

Resveratrol Production from Hydrothermally Pretreated Eucalyptus Wood Using Recombinant Industrial Saccharomyces cerevisiae Strains.

Autores: Carlos Costa; Iben Møller-Hansen; Aloia Romaní; José A. Teixeira; Irina Borodina; Lucília Domingues
Publicado en: reponame:Repositório Científico de Acesso Aberto de Portugal, Edición 1, 2021, ISSN 2161-5063
Editor: American Chemical Society
DOI: 10.1021/acssynbio.1c00120

Engineering of molybdenum-cofactor-dependent nitrate assimilation in Yarrowia lipolytica

Autores: Thomas Perli; Irina Borodina; Jean-Marc Daran
Publicado en: FEMS Yeast Research, Edición 1, 2021, ISSN 1567-1356
Editor: Blackwell
DOI: 10.1093/femsyr/foab050

An integrated yeast-based process for cis,cis-muconic acid production

Autores: Guokun Wang; Guokun Wang; Aline Tavares; Simone Schmitz; Simone Schmitz; Lucas Gabriel Souza França; Hugo Almeida; João Cavalheiro; Ana Carolas; Süleyman Øzmerih; Lars M. Blank; Bruno Sommer Ferreira; Irina Borodina
Publicado en: Biotechnology and Bioengineering, Edición 1, 2022, ISSN 0006-3592
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.27992

Energetic evolution of cellular Transportomes

Autores: Behrooz Darbani, Douglas B. Kell, Irina Borodina
Publicado en: BMC Genomics, Edición 19/1, 2018, ISSN 1471-2164
Editor: BioMed Central
DOI: 10.1186/s12864-018-4816-5

Engineering energetically efficient transport of dicarboxylic acids in yeast Saccharomyces cerevisiae

Autores: Behrooz Darbani, Vratislav Stovicek, Steven Axel van der Hoek, Irina Borodina
Publicado en: Proceedings of the National Academy of Sciences, Edición 116 (39), 2019, Página(s) 201900287, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1900287116

The Transcriptome and Flux Profiling of Crabtree‐Negative Hydroxy Acid‐Producing Strains of Saccharomyces cerevisiae Reveals Changes in the Central Carbon Metabolism

Autores: Mathew M. Jessop‐Fabre, Jonathan Dahlin, Mathias B. Biron, Vratislav Stovicek, Birgitta E. Ebert, Lars M. Blank, Itay Budin, Jay D. Keasling, Irina Borodina
Publicado en: Biotechnology Journal, Edición 14/9, 2019, Página(s) 1900013, ISSN 1860-6768
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201900013

Engineering the Yeast Saccharomyces cerevisiae for the Production of L-(+)-Ergothioneine

Autores: Steven A. van der Hoek, Behrooz Darbani, Karolina E. Zugaj, Bala Krishna Prabhala, Mathias Bernfried Biron, Milica Randelovic, Jacqueline B. Medina, Douglas B. Kell, Irina Borodina
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 7, 2019, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2019.00262

Multi-Omics Analysis of Fatty Alcohol Production in Engineered Yeasts Saccharomyces cerevisiae and Yarrowia lipolytica

Autores: Jonathan Dahlin, Carina Holkenbrink, Eko Roy Marella, Guokun Wang, Ulf Liebal, Christian Lieven, Dieter Weber, Douglas McCloskey, Birgitta E. Ebert, Markus J. Herrgård, Lars Mathias Blank, Irina Borodina
Publicado en: Frontiers in Genetics, Edición 10, 2019, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2019.00747

A single-host fermentation process for the production of flavor lactones from non-hydroxylated fatty acids

Autores: Eko Roy Marella, Jonathan Dahlin, Marie Inger Dam, Jolanda ter Horst, Hanne Bjerre Christensen, Suresh Sudarsan, Guokun Wang, Carina Holkenbrink, Irina Borodina
Publicado en: Metabolic Engineering, 2019, ISSN 1096-7176
Editor: Academic Press
DOI: 10.1016/j.ymben.2019.08.009

Improvement of cis , cis -Muconic Acid Production in Saccharomyces cerevisiae through Biosensor-Aided Genome Engineering

Autores: Guokun Wang, Süleyman Øzmerih, Rogério Guerreiro, Ana C. Meireles, Ana Carolas, Nicholas Milne, Michael K. Jensen, Bruno S. Ferreira, Irina Borodina
Publicado en: ACS Synthetic Biology, Edición 9/3, 2020, Página(s) 634-646, ISSN 2161-5063
Editor: American Chemical Society
DOI: 10.1021/acssynbio.9b00477

A teaching protocol demonstrating the use of EasyClone and CRISPR/Cas9 for metabolic engineering of Saccharomyces cerevisiae and Yarrowia lipolytica

Autores: N Milne, L R R Tramontin, I Borodina
Publicado en: FEMS Yeast Research, Edición Volume 20, Edición 2, March 2020, foz062, 2020, ISSN 1567-1356
Editor: Blackwell
DOI: 10.1093/femsyr/foz062

Enhancement of Astaxanthin Biosynthesis in Oleaginous Yeast Yarrowia lipolytica via Microalgal Pathway

Autores: Larissa Ribeiro Ramos Tramontin, Kanchana Rueksomtawin Kildegaard, Suresh Sudarsan, Irina Borodina
Publicado en: Microorganisms, Edición 7/10, 2019, Página(s) 472, ISSN 2076-2607
Editor: MDPI
DOI: 10.3390/microorganisms7100472

Metabolic engineering of Saccharomyces cerevisiae for the de novo production of psilocybin and related tryptamine derivatives

Autores: N. Milne, P. Thomsen, N. Mølgaard Knudsen, P. Rubaszka, M. Kristensen, I. Borodina
Publicado en: Metabolic Engineering, Edición 60, 2020, Página(s) 25-36, ISSN 1096-7176
Editor: Academic Press
DOI: 10.1016/j.ymben.2019.12.007

Engineering Oleaginous Yeast as the Host for Fermentative Succinic Acid Production From Glucose

Autores: Mahsa Babaei, Kanchana Rueksomtawin Kildegaard, Aligholi Niaei, Maryam Hosseini, Sirous Ebrahimi, Suresh Sudarsan, Irini Angelidaki, Irina Borodina
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 7, 2019, ISSN 2296-4185
Editor: Frontiers Media S.A.
DOI: 10.3389/fbioe.2019.00361

Identification and characterisation of two high-affinity glucose transporters from the spoilage yeast Brettanomyces bruxellensis

Autores: Ievgeniia A Tiukova, Iben Møller-Hansen, Zeinu M Belew, Behrooz Darbani, Eckhard Boles, Hussam H Nour-Eldin, Tomas Linder, Jens Nielsen, Irina Borodina
Publicado en: FEMS Microbiology Letters, Edición 366/17, 2019, ISSN 0378-1097
Editor: Blackwell
DOI: 10.1093/femsle/fnz222

Engineering ergothioneine production in Yarrowia lipolytica.

Autores: Steven Axel van der Hoek; Matej Rusnák; Irene Hjorth Jacobsen; José L. Martínez; Douglas B. Kell; Douglas B. Kell; Irina Borodina
Publicado en: van der Hoek , S A , Rusnák , M , Jacobsen , I H , Martínez , J L , Kell , D B & Borodina , I 2022 , ' Engineering ergothioneine production in Yarrowia lipolytica ' , FEBS Letters , vol. 596 , no. 10 , pp. 1356-1364 . https://doi.org/10.1002/1873-3468.14239, Edición 1, 2022, ISSN 0014-5793
Editor: Elsevier BV
DOI: 10.1002/1873-3468.14239

Transporter engineering in microbial cell factories: the ins, the outs, and the in-betweens.

Autores: Steven Axel van der Hoek; Irina Borodina
Publicado en: van der Hoek , S A & Borodina , I 2020 , ' Transporter engineering in microbial cell factories: the ins, the outs, and the in-betweens ' , Current Opinion in Biotechnology , vol. 66 , pp. 186-194 . https://doi.org/10.1016/j.copbio.2020.08.002, Edición 09581669, 2020, Página(s) 186-194, ISSN 0958-1669
Editor: Elsevier BV
DOI: 10.1016/j.copbio.2020.08.002

Yarrowia lipolytica Strains Engineered for the Production of Terpenoids

Autores: Jonathan Asmund Arnesen, Kanchana Rueksomtawin Kildegaard, Marc Cernuda Pastor, Sidharth Jayachandran, Mette Kristensen, Irina Borodina
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 8, 2020, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2020.00945

Transportome-wide engineering of Saccharomyces cerevisiae

Autores: Guokun Wang, Iben Møller-Hansen, Mahsa Babaei, Vasil D'Ambrosio, Hanne Bjerre Christensen, Behrooz Darbani, Michael Krogh Jensen, Irina Borodina
Publicado en: Metabolic Engineering, Edición 64, 2021, Página(s) 52-63, ISSN 1096-7176
Editor: Academic Press
DOI: 10.1016/j.ymben.2021.01.007

Valorisation of wine wastes by <i>de novo</i> biosynthesis of resveratrol using a recombinant xylose-consuming industrial <i>Saccharomyces cerevisiae</i> strain

Autores: Carlos E. Costa; Aloia Romaní; Iben Møller-Hansen; José A. Teixeira; Irina Borodina; Lucília Domingues
Publicado en: Green Chem, Edición 24, 2022, Página(s) 9128-9142, ISSN 1463-9262
Editor: Royal Society of Chemistry
DOI: 10.1039/d2gc02429b

Non-peer reviewed articles (1)

Understanding metabolite transport gives an upper hand in strain development

Autores: Irina Borodina
Publicado en: Microbial Biotechnology, Edición 12/1, 2019, Página(s) 69-70, ISSN 1751-7915
Editor: Wiley
DOI: 10.1111/1751-7915.13347

Other (1)

A Novel Efficient L-Lysine Exporter Identified by Functional Metagenomics

Autores: Sailesh Malla, Eric van der Helm, Behrooz Darbani, Stefan Wieschalka, Jochen Forster, Irina Borodina, Morten O. A. Sommer
Publicado en: 2020
Editor: biorxiv
DOI: 10.1101/2020.04.30.071142

Derechos de propiedad intelectual

Patent (1)

METHODS FOR PRODUCTION OF ERGOTHIONEINE

Número de solicitud/publicación: 20 20061866
Fecha: 2020-04-29
Solicitante(s): DANMARKS TEKNISKE UNIVERSITET