Understanding the evolution of plasmid-mediated antibiotic resistance in real life scenarios

Project Information

PLASREVOLUTION

Grant agreement ID: 757440

DOI

10.3030/757440

Project closed

EC signature date 6 November 2017

Start date 1 February 2018

End date 31 January 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 497 314,00

EU contribution

€ 1 497 314,00

Coordinated by

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

The distribution of fitness effects of plasmid pOXA-48 in clinical enterobacteria

Author(s): Ariadna Fernández-Calvet, Laura Toribio-Celestino, Aida Alonso-Del Valle, Jorge Sastre-Dominguez, Paula Valdes-Chiara, Alvaro San Millan, Javier DelaFuente
Published in: Microbiology, 2023, ISSN 0026-2617
Publisher: Maik Nauka/Interperiodica Publishing
DOI: 10.1099/mic.0.001369

Pervasive transmission of a carbapenem resistance plasmid in the gut microbiota of hospitalized patients

Author(s): Ricardo León-Sampedro, Javier DelaFuente, Cristina Díaz-Agero, Thomas Crellen, Patrick Musicha, Jerónimo Rodríguez-Beltrán, Carmen de la Vega, Marta Hernández-García, R-GNOSIS WP5 Study Group , Nieves López-Fresneña, Patricia Ruiz-Garbajosa, Rafael Cantón, Ben S Cooper, Álvaro San Millán
Published in: Nature Microbiology, 2021, ISSN 2058-5276
Publisher: Nature Publishing Group
DOI: 10.1038/s41564-021-00879-y

Within-patient evolution of plasmid-mediated antimicrobial resistance

Author(s): DelaFuente J, Toribio-Celestino L, Santos-Lopez A, León-Sampedro R, Alonso-Del Valle A, Costas C, Hernández-García M, Cui L, Rodríguez-Beltrán J, Bikard D, Cantón R, San Millan A
Published in: Nature Ecology and Evolution, Issue 6, 2022, Page(s) 1980–1991, ISSN 2397-334X
Publisher: Nature Publishing Group
DOI: 10.1038/s41559-022-01908-7

Variability of plasmid fitness effects contributes to plasmid persistence in bacterial communities

Author(s): Alonso-Del Valle A, León-Sampedro R, Rodríguez-Beltrán J, DelaFuente J, Hernández-García M, Ruiz-Garbajosa P, Cantón R, Peña-Miller R, San Millán A.
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22849-y

Collateral sensitivity associated with antibiotic resistance plasmids.

Author(s): Herencias C, Rodríguez-Beltrán J, León-Sampedro R, Alonso-Del Valle A, Palkovičová J, Cantón R, San Millán Á.
Published in: eLife, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.65130

Global epistasis in plasmid-mediated antimicrobial resistance

Author(s): Javier DelaFuente, Juan Diaz-Colung, Alvaro Sanchez, Alvaro San Millan
Published in: Molecular Systems Biology, 2024, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.1038/s44320-024-00012-1

Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria

Author(s): Aida Alonso-Del Valle, Laura Toribio-Celestino, Anna Quirant, Carles Tardio Pi, Javier DelaFuente, Rafael Canton, Eduardo P C Rocha, Carles Ubeda, Rafael Peña-Miller, Alvaro San Millan
Published in: Proceedings of the National Academy of Sciences of the USA, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2314135120

Evolution of Plasmid-Mediated Antibiotic Resistance in the Clinical Context

Author(s): Alvaro San Millan
Published in: Trends in Microbiology, Issue monthly, 2018, ISSN 0966-842X
Publisher: Elsevier BV
DOI: 10.1016/j.tim.2018.06.007

The evolution of antibiotic resistance

Author(s): R. Craig MacLean, Alvaro San Millan
Published in: Science, Issue 365/6458, 2019, Page(s) 1082-1083, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax3879

Genetic dominance governs the evolution and spread of mobile genetic elements in bacteria

Author(s): Jerónimo Rodríguez-Beltrán, Vidar Sørum, Macarena Toll-Riera, Carmen de la Vega, Rafael Peña-Miller, Álvaro San Millán
Published in: Proceedings of the National Academy of Sciences, Issue 117/27, 2020, Page(s) 15755-15762, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2001240117

Translational demand is not a major source of plasmid-associated fitness costs

Author(s): Rodríguez-Beltrán J, León-Sampedro R, Ramiro-Martínez P, de la Vega C, Baquero F, Levin BR, San Millán Á.
Published in: Philos Trans R Soc Lond B Biol Sci, 2021, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2020.0463