Rag-independent regulation of mTOR by Amino Acids

Project Information

noRAG-TOR

Grant agreement ID: 757729

DOI 10.3030/757729

Project closed

EC signature date 25 September 2017

Start date 1 February 2018

End date 31 January 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 756,00

EU contribution € 1 499 756,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

Publications

Peer reviewed articles (7)

TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

Author(s): Katharina Fitzian; Anne Brückner; Laura Brohée; Reinhard Zech; Claudia Antoni; Stephan Kiontke; Raphael Gasper; Anna Livia Linard Matos; Stephanie Beel; Sabine Wilhelm; Volker Gerke; Christian Ungermann; Mark Nellist; Stefan Raunser; Constantinos Demetriades; Andrea Oeckinghaus; Daniel Kümmel
Published in: Molecular Cell, Issue 2021 Jul 1;81(13), 2021, Page(s) 2705-2721, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.04.019

A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids

Author(s): Peter Gollwitzer, Nina Grützmacher, Sabine Wilhelm, Daniel Kümmel, Constantinos Demetriades
Published in: Nature Cell Biology, Issue 24, 2022, Page(s) 1394–1406, ISSN 1476-4679
Publisher: Springer Nature Limited
DOI: 10.1038/s41556-022-00976-y

The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging

Author(s): Stephanie A. Fernandes; Stephanie A. Fernandes; Constantinos Demetriades; Constantinos Demetriades; Constantinos Demetriades
Published in: Frontiers in Aging, Issue 2, 2021, ISSN 2673-6217
Publisher: Frontiers
DOI: 10.3389/fragi.2021.707372

Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity

Author(s): Wenming Huang; Chun Kew; Stephanie de Alcantara Fernandes; Anna Löhrke; Lynn Han; Constantinos Demetriades; Adam Antebi
Published in: Nature Aging, Issue 2, 2022, Page(s) 796–808, ISSN 2662-8465
Publisher: Springer Nature Limited
DOI: 10.1038/s43587-022-00275-z

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

Author(s): Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra,
Published in: Cell, Issue 184/3, 2021, Page(s) 655-674.e27, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.12.024

GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome

Author(s): Constantinos Demetriades; Julian Nüchel; Markus Plomann
Published in: Cell Stress, Issue 2021 Oct 15;5(11), 2021, Page(s) 173-175, ISSN 2523-0204
Publisher: Shared Science Publishers OG
DOI: 10.15698/cst2021.11.259

An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

Author(s): Julian Nüchel; Marina Tauber; Janica L. Nolte; Matthias Mörgelin; Clara Türk; Beate Eckes; Constantinos Demetriades; Constantinos Demetriades; Markus Plomann
Published in: Molecular Cell, Issue 2021 Aug 19;81(16), 2021, Page(s) 3275-3293, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.06.017

Other (2)

Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor

Author(s): Raffaele Nicastro, Laura Brohée, Josephine Alba, Julian Nüchel, Gianluca Figlia, Stefanie Kipschull, Peter Gollwitzer, Jesus Romero-Pozuelo, Stephanie A. Fernandes, Andreas Lamprakis, Stefano Vanni, Aurelio A. Teleman, Claudio De Virgilio, Constantinos Demetriades
Published in: bioRxiv, 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.11.06.515351

Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor

Author(s): Filippo Artoni, Nina Grützmacher, Constantinos Demetriades
Published in: bioRxiv, 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.12.10.519872