Rag-independent regulation of mTOR by Amino Acids

Publikacje

TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

Autorzy: Katharina Fitzian; Anne Brückner; Laura Brohée; Reinhard Zech; Claudia Antoni; Stephan Kiontke; Raphael Gasper; Anna Livia Linard Matos; Stephanie Beel; Sabine Wilhelm; Volker Gerke; Christian Ungermann; Mark Nellist; Stefan Raunser; Constantinos Demetriades; Andrea Oeckinghaus; Daniel Kümmel
Opublikowane w: Molecular Cell, Numer 2021 Jul 1;81(13), 2021, Strona(/y) 2705-2721, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2021.04.019

A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids

Autorzy: Peter Gollwitzer, Nina Grützmacher, Sabine Wilhelm, Daniel Kümmel, Constantinos Demetriades
Opublikowane w: Nature Cell Biology, Numer 24, 2022, Strona(/y) 1394–1406, ISSN 1476-4679
Wydawca: Springer Nature Limited
DOI: 10.1038/s41556-022-00976-y

The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging

Autorzy: Stephanie A. Fernandes; Stephanie A. Fernandes; Constantinos Demetriades; Constantinos Demetriades; Constantinos Demetriades
Opublikowane w: Frontiers in Aging, Numer 2, 2021, ISSN 2673-6217
Wydawca: Frontiers
DOI: 10.3389/fragi.2021.707372

Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity

Autorzy: Wenming Huang; Chun Kew; Stephanie de Alcantara Fernandes; Anna Löhrke; Lynn Han; Constantinos Demetriades; Adam Antebi
Opublikowane w: Nature Aging, Numer 2, 2022, Strona(/y) 796–808, ISSN 2662-8465
Wydawca: Springer Nature Limited
DOI: 10.1038/s43587-022-00275-z

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

Autorzy: Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra,
Opublikowane w: Cell, Numer 184/3, 2021, Strona(/y) 655-674.e27, ISSN 0092-8674
Wydawca: Cell Press
DOI: 10.1016/j.cell.2020.12.024

GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome

Autorzy: Constantinos Demetriades; Julian Nüchel; Markus Plomann
Opublikowane w: Cell Stress, Numer 2021 Oct 15;5(11), 2021, Strona(/y) 173-175, ISSN 2523-0204
Wydawca: Shared Science Publishers OG
DOI: 10.15698/cst2021.11.259

An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

Autorzy: Julian Nüchel; Marina Tauber; Janica L. Nolte; Matthias Mörgelin; Clara Türk; Beate Eckes; Constantinos Demetriades; Constantinos Demetriades; Markus Plomann
Opublikowane w: Molecular Cell, Numer 2021 Aug 19;81(16), 2021, Strona(/y) 3275-3293, ISSN 1097-2765
Wydawca: Cell Press
DOI: 10.1016/j.molcel.2021.06.017

Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor

Autorzy: Raffaele Nicastro, Laura Brohée, Josephine Alba, Julian Nüchel, Gianluca Figlia, Stefanie Kipschull, Peter Gollwitzer, Jesus Romero-Pozuelo, Stephanie A. Fernandes, Andreas Lamprakis, Stefano Vanni, Aurelio A. Teleman, Claudio De Virgilio, Constantinos Demetriades
Opublikowane w: bioRxiv, 2022
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.11.06.515351

Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor

Autorzy: Filippo Artoni, Nina Grützmacher, Constantinos Demetriades
Opublikowane w: bioRxiv, 2022
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.12.10.519872

Wyszukiwanie danych OpenAIRE...

Publikacje

Udostępnij tę stronę

Pobierz