Rag-independent regulation of mTOR by Amino Acids

Publicaciones

TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

Autores: Katharina Fitzian; Anne Brückner; Laura Brohée; Reinhard Zech; Claudia Antoni; Stephan Kiontke; Raphael Gasper; Anna Livia Linard Matos; Stephanie Beel; Sabine Wilhelm; Volker Gerke; Christian Ungermann; Mark Nellist; Stefan Raunser; Constantinos Demetriades; Andrea Oeckinghaus; Daniel Kümmel
Publicado en: Molecular Cell, Edición 2021 Jul 1;81(13), 2021, Página(s) 2705-2721, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2021.04.019

A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids

Autores: Peter Gollwitzer, Nina Grützmacher, Sabine Wilhelm, Daniel Kümmel, Constantinos Demetriades
Publicado en: Nature Cell Biology, Edición 24, 2022, Página(s) 1394–1406, ISSN 1476-4679
Editor: Springer Nature Limited
DOI: 10.1038/s41556-022-00976-y

The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging

Autores: Stephanie A. Fernandes; Stephanie A. Fernandes; Constantinos Demetriades; Constantinos Demetriades; Constantinos Demetriades
Publicado en: Frontiers in Aging, Edición 2, 2021, ISSN 2673-6217
Editor: Frontiers
DOI: 10.3389/fragi.2021.707372

Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity

Autores: Wenming Huang; Chun Kew; Stephanie de Alcantara Fernandes; Anna Löhrke; Lynn Han; Constantinos Demetriades; Adam Antebi
Publicado en: Nature Aging, Edición 2, 2022, Página(s) 796–808, ISSN 2662-8465
Editor: Springer Nature Limited
DOI: 10.1038/s43587-022-00275-z

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

Autores: Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra,
Publicado en: Cell, Edición 184/3, 2021, Página(s) 655-674.e27, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.12.024

GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome

Autores: Constantinos Demetriades; Julian Nüchel; Markus Plomann
Publicado en: Cell Stress, Edición 2021 Oct 15;5(11), 2021, Página(s) 173-175, ISSN 2523-0204
Editor: Shared Science Publishers OG
DOI: 10.15698/cst2021.11.259

An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

Autores: Julian Nüchel; Marina Tauber; Janica L. Nolte; Matthias Mörgelin; Clara Türk; Beate Eckes; Constantinos Demetriades; Constantinos Demetriades; Markus Plomann
Publicado en: Molecular Cell, Edición 2021 Aug 19;81(16), 2021, Página(s) 3275-3293, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2021.06.017

Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor

Autores: Raffaele Nicastro, Laura Brohée, Josephine Alba, Julian Nüchel, Gianluca Figlia, Stefanie Kipschull, Peter Gollwitzer, Jesus Romero-Pozuelo, Stephanie A. Fernandes, Andreas Lamprakis, Stefano Vanni, Aurelio A. Teleman, Claudio De Virgilio, Constantinos Demetriades
Publicado en: bioRxiv, 2022
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.11.06.515351

Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor

Autores: Filippo Artoni, Nina Grützmacher, Constantinos Demetriades
Publicado en: bioRxiv, 2022
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.12.10.519872

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