Function of long non-coding RNA in Crohn Disease Ulcer Pathogenesis

Información del proyecto

cureCD

Identificador del acuerdo de subvención: 758313

DOI

10.3030/758313

Proyecto cerrado

Fecha de la firma de la CE 28 Marzo 2018

Fecha de inicio 1 Mayo 2018

Fecha de finalización 31 Octubre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 500 000,00

Aportación de la UE

€ 1 500 000,00

Coordinado por

MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER
Israel

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (19)

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Autores: Yael Haberman, Rebekah Karns, Phillip J. Dexheimer, Melanie Schirmer, Judith Somekh, Ingrid Jurickova, Tzipi Braun, Elizabeth Novak, Laura Bauman, Margaret H. Collins, Angela Mo, Michael J. Rosen, Erin Bonkowski, Nathan Gotman, Alison Marquis, Mason Nistel, Paul A. Rufo, Susan S. Baker, Cary G. Sauer, James Markowitz, Marian D. Pfefferkorn, Joel R. Rosh, Brendan M. Boyle, David R. Mack, Robert N.
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-07841-3

Baseline peripheral blood mononuclear cell (PBMC) transcriptomics before ustekinumab treatment is linked with Crohn Disease clinical response at 1 year

Autores: Maya Granot, Tzipi Braun, Gilat Efroni, Orit Picard, Ella Fudim, Miri Yavzori, Ola Haj, Batia Weiss, Shomron Ben-Horin, Uri Kopylov, Yael Haberman
Publicado en: Clinical and Translational Gastroenterology, 2024, ISSN 2155-384X
Editor: Nature Publishing Group
DOI: 10.14309/ctg.0000000000000635

All (remains) in the family? Using healthy relatives to define Crohn’s gut microbiome alterations

Autores: Amnon Amir, Yael Haberman
Publicado en: Cell Reports Medicine, Edición 5, 2024, Página(s) 101651, ISSN 2666-3791
Editor: Cell
DOI: 10.1016/j.xcrm.2024.101651

Individualized Dynamics in the Gut Microbiota Precede Crohnʼs Disease Flares

Autores: Tzipi Braun, Ayelet Di Segni, Marina BenShoshan, Sandra Neuman, Nina Levhar, Michael Bubis, Orit Picard, Katya Sosnovski, Gilat Efroni, Sarit Farage Barhom, Efrat Glick Saar, Avishay Lahad, Batia Weiss, Doron Yablecovitch, Adi Lahat, Rami Eliakim, Uri Kopylov, Shomron Ben-Horin, Yael Haberman
Publicado en: The American Journal of Gastroenterology, Edición 114/7, 2019, Página(s) 1142-1151, ISSN 0002-9270
Editor: Blackwell Publishing Inc.
DOI: 10.14309/ajg.0000000000000136

Reduced LHFPL3-AS2 lncRNA expression is linked to altered epithelial polarity and proliferation, and to ileal ulceration in Crohn disease

Autores: Katya E. Sosnovski, Tzipi Braun, Amnon Amir, Marina BenShoshan, Haya Abbas-Egbariya, Rakefet Ben-Yishay, Liat Anafi, Camilla Avivi, Iris Barshack, Lee A. Denson, Yael Haberman
Publicado en: Scientific Reports, Edición 13, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-47997-7

Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn’s Disease Strictures

Autores: Ingrid Jurickova, Erin Bonkowski, Elizabeth Angerman, Elizabeth Novak, Alex Huron, Grayce Akers,, Kentaro Iwasawa, Tzipi Braun, Rotem Hadar, Maria Hooker, Sarah Han, David J Cutler, David T Okou, Subra Kugathasan, Anil Jegga, James Wells, Takanori Takebe, Kevin P Mollen, Yael Haberman, Lee A Denson
Publicado en: Inflammatory Bowel Diseases, Edición 28, 2022, Página(s) 988-1003, ISSN 1078-0998
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1093/ibd/izac037

Lack of gut microbiome recovery with spinal cord injury rehabilitation

Autores: Ayelet Gur Arie, Itamar Toren, Rotem Hadar, Tzipi Braun, Gilat Efroni, Efrat Glick Saar, Zecharia Madar, Amnon Amir, Gabriel Zeilig, Yael Haberman
Publicado en: Gut Microbes, Edición 16, 2024, ISSN 1949-0976
Editor: Landes Bioscience
DOI: 10.1080/19490976.2024.2309682

Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease

Autores: Yael Haberman, Marina BenShoshan, Ayelet Di Segni, Phillip J Dexheimer, Tzipi Braun, Batia Weiss, Thomas D Walters, Robert N Baldassano, Joshua D Noe, James Markowitz, Joel Rosh, Melvin B Heyman, Anne M Griffiths, Wallace V Crandall, David R Mack, Susan S Baker, Richard Kellermayer, Ashish Patel, Anthony Otley, Steven J Steiner, Ajay S Gulati, Stephen L Guthery, Neal LeLeiko, Dedrick Moulton, Barb
Publicado en: Inflammatory Bowel Diseases, Edición 24/2, 2018, Página(s) 346-360, ISSN 1078-0998
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1093/ibd/izx013

Meta-analysis defines predominant shared microbial responses in various diseases and a specific inflammatory bowel disease signal

Autores: Haya Abbas-Egbariya, Yael Haberman, Tzipi Braun, Rotem Hadar, Lee Denson, Ohad Gal-Mor, Amnon Amir
Publicado en: Genome Biology, Edición 23, 2022, ISSN 1474-760X
Editor: Nature
DOI: 10.1186/s13059-022-02637-7

Defining the Celiac Disease Transcriptome using Clinical Pathology Specimens Reveals Biologic Pathways and Supports Diagnosis

Autores: Nurit Loberman-Nachum, Katya Sosnovski, Ayelet Di Segni, Gilat Efroni, Tzipi Braun, Marina BenShoshan, Lait Anafi, Camila Avivi, Iris Barshack, Dror S. Shouval, Lee A. Denson, Amnon Amir, Ron Unger, Batia Weiss, Yael Haberman
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-52733-1

Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis

Autores: Yael Haberman, Melanie Schirmer, Phillip J. Dexheimer, Rebekah Karns, Tzipi Braun, Mi-Ok Kim, Thomas D. Walters, Robert N. Baldassano, Joshua D. Noe, Joel Rosh, James Markowitz, Wallace V. Crandall, David R. Mack, Anne M. Griffiths, Melvin B. Heyman, Susan S. Baker, Richard Kellermayer, Dedrick Moulton, Ashish S. Patel, Ajay S. Gulati, Steven J. Steiner, Neal LeLeiko, Anthony Otley, Maria Oliva-He
Publicado en: Mucosal Immunology, Edición 12/2, 2019, Página(s) 491-502, ISSN 1933-0219
Editor: Nature Publishing Group
DOI: 10.1038/s41385-018-0114-4

Mucosal Genomics Implicate Lymphocyte Activation and Lipid Metabolism in Refractory Environmental Enteric Dysfunction

Autores: Yael Haberman, Najeeha T. Iqbal, Sudhir Ghandikota, Indika Mallawaarachchi, null Tzipi Braun, Phillip J. Dexheimer, Najeeb Rahman, Rotem Hadar, Kamran Sadiq, Zubair Ahmad, Romana Idress, Junaid Iqbal, Sheraz Ahmed, Aneeta Hotwani, Fayyaz Umrani, Lubaina Ehsan, Greg Medlock, Sana Syed, Chris Moskaluk, Jennie Z. Ma, Anil G. Jegga, Sean R. Moore, Syed Asad Ali, Lee A. Denson
Publicado en: Gastroenterology, Edición 160, 2021, Página(s) 2055-2071.e0, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.01.221

Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn’s disease, and celiac disease

Autores: Tzipi Braun, Katya E. Sosnovski, Amnon Amir, Marina BenShoshan, Kelli L. VanDussen, Rebekah Karns, Nina Levhar, Haya Abbas-Egbariya, Rotem Hadar, Gilat Efroni, David Castel, Camila Avivi, Michael J. Rosen, Anne M. Grifiths, Thomas D. Walters, David R. Mack, Brendan M. Boyle, Syed Asad Ali, Sean R. Moore, Melanie Schirmer, Ramnik J. Xavier, Subra Kugathasan, Anil G. Jegga, Batya Weiss, Chen Mayer,
Publicado en: JCI Insight, Edición 8, 2023, ISSN 2379-3708
Editor: American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.170181

<i>GATA6-AS1</i> Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis

Autores: Katya E Sosnovski, Tzipi Braun, Amnon Amir, Danielle Moshel, Marina BenShoshan, Kelli L VanDussen, Nina Levhar, Haya Abbas-Egbariya, Katia Beider, Rakefet Ben-Yishay, Syed Asad Ali, Sean R Moore, Subra Kugathasan, Ifat Abramovich, Efrat Glick Saar, Batya Weiss, Iris Barshack, Eyal Gottlieb, Tamar Geiger, Shomron Ben-Horin, Igor Ulitsky, Jeffrey S Hyams, Lee A Denson, Yael Haberman
Publicado en: Journal of Crohn's and Colitis, Edición 17, 2023, Página(s) 960-971, ISSN 1873-9946
Editor: Elsevier Science
DOI: 10.1093/ecco-jcc/jjad006

SARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition

Autores: Tzipi Braun, Shiraz Halevi, Rotem Hadar, Gilate Efroni, Efrat Glick Saar, Natahan Keller, Amnon Amir, Sharon Amit, Yael Haberman
Publicado en: Scientific Reports, Edición 11, 2022, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-88536-6

Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort

Autores: Tzipi Braun, Rui Feng, Amnon Amir, Nina Levhar, Hila Shacham, Ren Mao, Rotem Hadar, Itamar Toren, Yadid Algavi, Kathleen Abu-Saad, Shuoyu Zhuo, Gilat Efroni, Alona Malik, Orit Picard, Miri Yavzori, Bella Agranovich, Ta-Chiang Liu, Thaddeus S. Stappenbeck, Lee Denson, Ofra Kalter-Leibovici, Eyal Gottlieb, Elhanan Borenstein, Eran Elinav, Minhu Chen, Shomron Ben-Horin, Yael Haberman
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-48106-6

Gut microbial signature in lung cancer patients highlights specific taxa as predictors for durable clinical benefit

Autores: Yael Haberman, Iris Kamer, Amnon Amir, Sapir Goldenberg, Gilat Efroni, Inbal Daniel-Meshulam, Anastasiya Lobachov, Sameh Daher, Rotem Hadar, Hadas Gantz-Sorotsky, Damien Urban, Tzipi Braun, Jair Bar
Publicado en: Scientific Reports, Edición 13, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-29136-4

Gut microbiome development in early childhood is affected by day care attendance

Autores: Amnon Amir, Ortal Erez-Granat, Tzipi Braun, Katya Sosnovski, Rotem Hadar, Marina BenShoshan, Sophia Heiman, Haya Abbas-Egbariya, Efrat Glick Saar, Gilat Efroni, Yael Haberman
Publicado en: npj Biofilms and Microbiomes, Edición 8, 2022, ISSN 2055-5008
Editor: Nature
DOI: 10.1038/s41522-021-00265-w

Tissue-based Gene Expression as Potential Biomarkers for IBD Course

Autores: Yael Haberman
Publicado en: Inflammatory Bowel Diseases, Edición 26/10, 2020, Página(s) 1485-1489, ISSN 1078-0998
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1093/ibd/izaa217