Function of long non-coding RNA in Crohn Disease Ulcer Pathogenesis

Informazioni relative al progetto

cureCD

ID dell’accordo di sovvenzione: 758313

DOI

10.3030/758313

Progetto chiuso

Data della firma CE 28 Marzo 2018

Data di avvio 1 Maggio 2018

Data di completamento 31 Ottobre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 500 000,00

Contributo UE

€ 1 500 000,00

Coordinato da

MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER
Israel

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (19)

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Autori: Yael Haberman, Rebekah Karns, Phillip J. Dexheimer, Melanie Schirmer, Judith Somekh, Ingrid Jurickova, Tzipi Braun, Elizabeth Novak, Laura Bauman, Margaret H. Collins, Angela Mo, Michael J. Rosen, Erin Bonkowski, Nathan Gotman, Alison Marquis, Mason Nistel, Paul A. Rufo, Susan S. Baker, Cary G. Sauer, James Markowitz, Marian D. Pfefferkorn, Joel R. Rosh, Brendan M. Boyle, David R. Mack, Robert N.
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-07841-3

Baseline peripheral blood mononuclear cell (PBMC) transcriptomics before ustekinumab treatment is linked with Crohn Disease clinical response at 1 year

Autori: Maya Granot, Tzipi Braun, Gilat Efroni, Orit Picard, Ella Fudim, Miri Yavzori, Ola Haj, Batia Weiss, Shomron Ben-Horin, Uri Kopylov, Yael Haberman
Pubblicato in: Clinical and Translational Gastroenterology, 2024, ISSN 2155-384X
Editore: Nature Publishing Group
DOI: 10.14309/ctg.0000000000000635

All (remains) in the family? Using healthy relatives to define Crohn’s gut microbiome alterations

Autori: Amnon Amir, Yael Haberman
Pubblicato in: Cell Reports Medicine, Numero 5, 2024, Pagina/e 101651, ISSN 2666-3791
Editore: Cell
DOI: 10.1016/j.xcrm.2024.101651

Individualized Dynamics in the Gut Microbiota Precede Crohnʼs Disease Flares

Autori: Tzipi Braun, Ayelet Di Segni, Marina BenShoshan, Sandra Neuman, Nina Levhar, Michael Bubis, Orit Picard, Katya Sosnovski, Gilat Efroni, Sarit Farage Barhom, Efrat Glick Saar, Avishay Lahad, Batia Weiss, Doron Yablecovitch, Adi Lahat, Rami Eliakim, Uri Kopylov, Shomron Ben-Horin, Yael Haberman
Pubblicato in: The American Journal of Gastroenterology, Numero 114/7, 2019, Pagina/e 1142-1151, ISSN 0002-9270
Editore: Blackwell Publishing Inc.
DOI: 10.14309/ajg.0000000000000136

Reduced LHFPL3-AS2 lncRNA expression is linked to altered epithelial polarity and proliferation, and to ileal ulceration in Crohn disease

Autori: Katya E. Sosnovski, Tzipi Braun, Amnon Amir, Marina BenShoshan, Haya Abbas-Egbariya, Rakefet Ben-Yishay, Liat Anafi, Camilla Avivi, Iris Barshack, Lee A. Denson, Yael Haberman
Pubblicato in: Scientific Reports, Numero 13, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-47997-7

Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn’s Disease Strictures

Autori: Ingrid Jurickova, Erin Bonkowski, Elizabeth Angerman, Elizabeth Novak, Alex Huron, Grayce Akers,, Kentaro Iwasawa, Tzipi Braun, Rotem Hadar, Maria Hooker, Sarah Han, David J Cutler, David T Okou, Subra Kugathasan, Anil Jegga, James Wells, Takanori Takebe, Kevin P Mollen, Yael Haberman, Lee A Denson
Pubblicato in: Inflammatory Bowel Diseases, Numero 28, 2022, Pagina/e 988-1003, ISSN 1078-0998
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1093/ibd/izac037

Lack of gut microbiome recovery with spinal cord injury rehabilitation

Autori: Ayelet Gur Arie, Itamar Toren, Rotem Hadar, Tzipi Braun, Gilat Efroni, Efrat Glick Saar, Zecharia Madar, Amnon Amir, Gabriel Zeilig, Yael Haberman
Pubblicato in: Gut Microbes, Numero 16, 2024, ISSN 1949-0976
Editore: Landes Bioscience
DOI: 10.1080/19490976.2024.2309682

Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease

Autori: Yael Haberman, Marina BenShoshan, Ayelet Di Segni, Phillip J Dexheimer, Tzipi Braun, Batia Weiss, Thomas D Walters, Robert N Baldassano, Joshua D Noe, James Markowitz, Joel Rosh, Melvin B Heyman, Anne M Griffiths, Wallace V Crandall, David R Mack, Susan S Baker, Richard Kellermayer, Ashish Patel, Anthony Otley, Steven J Steiner, Ajay S Gulati, Stephen L Guthery, Neal LeLeiko, Dedrick Moulton, Barb
Pubblicato in: Inflammatory Bowel Diseases, Numero 24/2, 2018, Pagina/e 346-360, ISSN 1078-0998
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1093/ibd/izx013

Meta-analysis defines predominant shared microbial responses in various diseases and a specific inflammatory bowel disease signal

Autori: Haya Abbas-Egbariya, Yael Haberman, Tzipi Braun, Rotem Hadar, Lee Denson, Ohad Gal-Mor, Amnon Amir
Pubblicato in: Genome Biology, Numero 23, 2022, ISSN 1474-760X
Editore: Nature
DOI: 10.1186/s13059-022-02637-7

Defining the Celiac Disease Transcriptome using Clinical Pathology Specimens Reveals Biologic Pathways and Supports Diagnosis

Autori: Nurit Loberman-Nachum, Katya Sosnovski, Ayelet Di Segni, Gilat Efroni, Tzipi Braun, Marina BenShoshan, Lait Anafi, Camila Avivi, Iris Barshack, Dror S. Shouval, Lee A. Denson, Amnon Amir, Ron Unger, Batia Weiss, Yael Haberman
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-52733-1

Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis

Autori: Yael Haberman, Melanie Schirmer, Phillip J. Dexheimer, Rebekah Karns, Tzipi Braun, Mi-Ok Kim, Thomas D. Walters, Robert N. Baldassano, Joshua D. Noe, Joel Rosh, James Markowitz, Wallace V. Crandall, David R. Mack, Anne M. Griffiths, Melvin B. Heyman, Susan S. Baker, Richard Kellermayer, Dedrick Moulton, Ashish S. Patel, Ajay S. Gulati, Steven J. Steiner, Neal LeLeiko, Anthony Otley, Maria Oliva-He
Pubblicato in: Mucosal Immunology, Numero 12/2, 2019, Pagina/e 491-502, ISSN 1933-0219
Editore: Nature Publishing Group
DOI: 10.1038/s41385-018-0114-4

Mucosal Genomics Implicate Lymphocyte Activation and Lipid Metabolism in Refractory Environmental Enteric Dysfunction

Autori: Yael Haberman, Najeeha T. Iqbal, Sudhir Ghandikota, Indika Mallawaarachchi, null Tzipi Braun, Phillip J. Dexheimer, Najeeb Rahman, Rotem Hadar, Kamran Sadiq, Zubair Ahmad, Romana Idress, Junaid Iqbal, Sheraz Ahmed, Aneeta Hotwani, Fayyaz Umrani, Lubaina Ehsan, Greg Medlock, Sana Syed, Chris Moskaluk, Jennie Z. Ma, Anil G. Jegga, Sean R. Moore, Syed Asad Ali, Lee A. Denson
Pubblicato in: Gastroenterology, Numero 160, 2021, Pagina/e 2055-2071.e0, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.01.221

Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn’s disease, and celiac disease

Autori: Tzipi Braun, Katya E. Sosnovski, Amnon Amir, Marina BenShoshan, Kelli L. VanDussen, Rebekah Karns, Nina Levhar, Haya Abbas-Egbariya, Rotem Hadar, Gilat Efroni, David Castel, Camila Avivi, Michael J. Rosen, Anne M. Grifiths, Thomas D. Walters, David R. Mack, Brendan M. Boyle, Syed Asad Ali, Sean R. Moore, Melanie Schirmer, Ramnik J. Xavier, Subra Kugathasan, Anil G. Jegga, Batya Weiss, Chen Mayer,
Pubblicato in: JCI Insight, Numero 8, 2023, ISSN 2379-3708
Editore: American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.170181

<i>GATA6-AS1</i> Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis

Autori: Katya E Sosnovski, Tzipi Braun, Amnon Amir, Danielle Moshel, Marina BenShoshan, Kelli L VanDussen, Nina Levhar, Haya Abbas-Egbariya, Katia Beider, Rakefet Ben-Yishay, Syed Asad Ali, Sean R Moore, Subra Kugathasan, Ifat Abramovich, Efrat Glick Saar, Batya Weiss, Iris Barshack, Eyal Gottlieb, Tamar Geiger, Shomron Ben-Horin, Igor Ulitsky, Jeffrey S Hyams, Lee A Denson, Yael Haberman
Pubblicato in: Journal of Crohn's and Colitis, Numero 17, 2023, Pagina/e 960-971, ISSN 1873-9946
Editore: Elsevier Science
DOI: 10.1093/ecco-jcc/jjad006

SARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition

Autori: Tzipi Braun, Shiraz Halevi, Rotem Hadar, Gilate Efroni, Efrat Glick Saar, Natahan Keller, Amnon Amir, Sharon Amit, Yael Haberman
Pubblicato in: Scientific Reports, Numero 11, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-88536-6

Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort

Autori: Tzipi Braun, Rui Feng, Amnon Amir, Nina Levhar, Hila Shacham, Ren Mao, Rotem Hadar, Itamar Toren, Yadid Algavi, Kathleen Abu-Saad, Shuoyu Zhuo, Gilat Efroni, Alona Malik, Orit Picard, Miri Yavzori, Bella Agranovich, Ta-Chiang Liu, Thaddeus S. Stappenbeck, Lee Denson, Ofra Kalter-Leibovici, Eyal Gottlieb, Elhanan Borenstein, Eran Elinav, Minhu Chen, Shomron Ben-Horin, Yael Haberman
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-48106-6

Gut microbial signature in lung cancer patients highlights specific taxa as predictors for durable clinical benefit

Autori: Yael Haberman, Iris Kamer, Amnon Amir, Sapir Goldenberg, Gilat Efroni, Inbal Daniel-Meshulam, Anastasiya Lobachov, Sameh Daher, Rotem Hadar, Hadas Gantz-Sorotsky, Damien Urban, Tzipi Braun, Jair Bar
Pubblicato in: Scientific Reports, Numero 13, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-29136-4

Gut microbiome development in early childhood is affected by day care attendance

Autori: Amnon Amir, Ortal Erez-Granat, Tzipi Braun, Katya Sosnovski, Rotem Hadar, Marina BenShoshan, Sophia Heiman, Haya Abbas-Egbariya, Efrat Glick Saar, Gilat Efroni, Yael Haberman
Pubblicato in: npj Biofilms and Microbiomes, Numero 8, 2022, ISSN 2055-5008
Editore: Nature
DOI: 10.1038/s41522-021-00265-w

Tissue-based Gene Expression as Potential Biomarkers for IBD Course

Autori: Yael Haberman
Pubblicato in: Inflammatory Bowel Diseases, Numero 26/10, 2020, Pagina/e 1485-1489, ISSN 1078-0998
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1093/ibd/izaa217