Function of long non-coding RNA in Crohn Disease Ulcer Pathogenesis

Informacje na temat projektu

cureCD

Identyfikator umowy o grant: 758313

DOI

10.3030/758313

Projekt został zamknięty

Data podpisania przez KE 28 Marca 2018

Data rozpoczęcia 1 Maja 2018

Data zakończenia 31 Października 2024

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 500 000,00

Wkład UE

€ 1 500 000,00

Koordynowany przez

MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER
Israel

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (19)

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Autorzy: Yael Haberman, Rebekah Karns, Phillip J. Dexheimer, Melanie Schirmer, Judith Somekh, Ingrid Jurickova, Tzipi Braun, Elizabeth Novak, Laura Bauman, Margaret H. Collins, Angela Mo, Michael J. Rosen, Erin Bonkowski, Nathan Gotman, Alison Marquis, Mason Nistel, Paul A. Rufo, Susan S. Baker, Cary G. Sauer, James Markowitz, Marian D. Pfefferkorn, Joel R. Rosh, Brendan M. Boyle, David R. Mack, Robert N.
Opublikowane w: Nature Communications, Numer 10/1, 2019, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-018-07841-3

Baseline peripheral blood mononuclear cell (PBMC) transcriptomics before ustekinumab treatment is linked with Crohn Disease clinical response at 1 year

Autorzy: Maya Granot, Tzipi Braun, Gilat Efroni, Orit Picard, Ella Fudim, Miri Yavzori, Ola Haj, Batia Weiss, Shomron Ben-Horin, Uri Kopylov, Yael Haberman
Opublikowane w: Clinical and Translational Gastroenterology, 2024, ISSN 2155-384X
Wydawca: Nature Publishing Group
DOI: 10.14309/ctg.0000000000000635

All (remains) in the family? Using healthy relatives to define Crohn’s gut microbiome alterations

Autorzy: Amnon Amir, Yael Haberman
Opublikowane w: Cell Reports Medicine, Numer 5, 2024, Strona(/y) 101651, ISSN 2666-3791
Wydawca: Cell
DOI: 10.1016/j.xcrm.2024.101651

Individualized Dynamics in the Gut Microbiota Precede Crohnʼs Disease Flares

Autorzy: Tzipi Braun, Ayelet Di Segni, Marina BenShoshan, Sandra Neuman, Nina Levhar, Michael Bubis, Orit Picard, Katya Sosnovski, Gilat Efroni, Sarit Farage Barhom, Efrat Glick Saar, Avishay Lahad, Batia Weiss, Doron Yablecovitch, Adi Lahat, Rami Eliakim, Uri Kopylov, Shomron Ben-Horin, Yael Haberman
Opublikowane w: The American Journal of Gastroenterology, Numer 114/7, 2019, Strona(/y) 1142-1151, ISSN 0002-9270
Wydawca: Blackwell Publishing Inc.
DOI: 10.14309/ajg.0000000000000136

Reduced LHFPL3-AS2 lncRNA expression is linked to altered epithelial polarity and proliferation, and to ileal ulceration in Crohn disease

Autorzy: Katya E. Sosnovski, Tzipi Braun, Amnon Amir, Marina BenShoshan, Haya Abbas-Egbariya, Rakefet Ben-Yishay, Liat Anafi, Camilla Avivi, Iris Barshack, Lee A. Denson, Yael Haberman
Opublikowane w: Scientific Reports, Numer 13, 2023, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-023-47997-7

Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn’s Disease Strictures

Autorzy: Ingrid Jurickova, Erin Bonkowski, Elizabeth Angerman, Elizabeth Novak, Alex Huron, Grayce Akers,, Kentaro Iwasawa, Tzipi Braun, Rotem Hadar, Maria Hooker, Sarah Han, David J Cutler, David T Okou, Subra Kugathasan, Anil Jegga, James Wells, Takanori Takebe, Kevin P Mollen, Yael Haberman, Lee A Denson
Opublikowane w: Inflammatory Bowel Diseases, Numer 28, 2022, Strona(/y) 988-1003, ISSN 1078-0998
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1093/ibd/izac037

Lack of gut microbiome recovery with spinal cord injury rehabilitation

Autorzy: Ayelet Gur Arie, Itamar Toren, Rotem Hadar, Tzipi Braun, Gilat Efroni, Efrat Glick Saar, Zecharia Madar, Amnon Amir, Gabriel Zeilig, Yael Haberman
Opublikowane w: Gut Microbes, Numer 16, 2024, ISSN 1949-0976
Wydawca: Landes Bioscience
DOI: 10.1080/19490976.2024.2309682

Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease

Autorzy: Yael Haberman, Marina BenShoshan, Ayelet Di Segni, Phillip J Dexheimer, Tzipi Braun, Batia Weiss, Thomas D Walters, Robert N Baldassano, Joshua D Noe, James Markowitz, Joel Rosh, Melvin B Heyman, Anne M Griffiths, Wallace V Crandall, David R Mack, Susan S Baker, Richard Kellermayer, Ashish Patel, Anthony Otley, Steven J Steiner, Ajay S Gulati, Stephen L Guthery, Neal LeLeiko, Dedrick Moulton, Barb
Opublikowane w: Inflammatory Bowel Diseases, Numer 24/2, 2018, Strona(/y) 346-360, ISSN 1078-0998
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1093/ibd/izx013

Meta-analysis defines predominant shared microbial responses in various diseases and a specific inflammatory bowel disease signal

Autorzy: Haya Abbas-Egbariya, Yael Haberman, Tzipi Braun, Rotem Hadar, Lee Denson, Ohad Gal-Mor, Amnon Amir
Opublikowane w: Genome Biology, Numer 23, 2022, ISSN 1474-760X
Wydawca: Nature
DOI: 10.1186/s13059-022-02637-7

Defining the Celiac Disease Transcriptome using Clinical Pathology Specimens Reveals Biologic Pathways and Supports Diagnosis

Autorzy: Nurit Loberman-Nachum, Katya Sosnovski, Ayelet Di Segni, Gilat Efroni, Tzipi Braun, Marina BenShoshan, Lait Anafi, Camila Avivi, Iris Barshack, Dror S. Shouval, Lee A. Denson, Amnon Amir, Ron Unger, Batia Weiss, Yael Haberman
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-52733-1

Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis

Autorzy: Yael Haberman, Melanie Schirmer, Phillip J. Dexheimer, Rebekah Karns, Tzipi Braun, Mi-Ok Kim, Thomas D. Walters, Robert N. Baldassano, Joshua D. Noe, Joel Rosh, James Markowitz, Wallace V. Crandall, David R. Mack, Anne M. Griffiths, Melvin B. Heyman, Susan S. Baker, Richard Kellermayer, Dedrick Moulton, Ashish S. Patel, Ajay S. Gulati, Steven J. Steiner, Neal LeLeiko, Anthony Otley, Maria Oliva-He
Opublikowane w: Mucosal Immunology, Numer 12/2, 2019, Strona(/y) 491-502, ISSN 1933-0219
Wydawca: Nature Publishing Group
DOI: 10.1038/s41385-018-0114-4

Mucosal Genomics Implicate Lymphocyte Activation and Lipid Metabolism in Refractory Environmental Enteric Dysfunction

Autorzy: Yael Haberman, Najeeha T. Iqbal, Sudhir Ghandikota, Indika Mallawaarachchi, null Tzipi Braun, Phillip J. Dexheimer, Najeeb Rahman, Rotem Hadar, Kamran Sadiq, Zubair Ahmad, Romana Idress, Junaid Iqbal, Sheraz Ahmed, Aneeta Hotwani, Fayyaz Umrani, Lubaina Ehsan, Greg Medlock, Sana Syed, Chris Moskaluk, Jennie Z. Ma, Anil G. Jegga, Sean R. Moore, Syed Asad Ali, Lee A. Denson
Opublikowane w: Gastroenterology, Numer 160, 2021, Strona(/y) 2055-2071.e0, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.01.221

Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn’s disease, and celiac disease

Autorzy: Tzipi Braun, Katya E. Sosnovski, Amnon Amir, Marina BenShoshan, Kelli L. VanDussen, Rebekah Karns, Nina Levhar, Haya Abbas-Egbariya, Rotem Hadar, Gilat Efroni, David Castel, Camila Avivi, Michael J. Rosen, Anne M. Grifiths, Thomas D. Walters, David R. Mack, Brendan M. Boyle, Syed Asad Ali, Sean R. Moore, Melanie Schirmer, Ramnik J. Xavier, Subra Kugathasan, Anil G. Jegga, Batya Weiss, Chen Mayer,
Opublikowane w: JCI Insight, Numer 8, 2023, ISSN 2379-3708
Wydawca: American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.170181

<i>GATA6-AS1</i> Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis

Autorzy: Katya E Sosnovski, Tzipi Braun, Amnon Amir, Danielle Moshel, Marina BenShoshan, Kelli L VanDussen, Nina Levhar, Haya Abbas-Egbariya, Katia Beider, Rakefet Ben-Yishay, Syed Asad Ali, Sean R Moore, Subra Kugathasan, Ifat Abramovich, Efrat Glick Saar, Batya Weiss, Iris Barshack, Eyal Gottlieb, Tamar Geiger, Shomron Ben-Horin, Igor Ulitsky, Jeffrey S Hyams, Lee A Denson, Yael Haberman
Opublikowane w: Journal of Crohn's and Colitis, Numer 17, 2023, Strona(/y) 960-971, ISSN 1873-9946
Wydawca: Elsevier Science
DOI: 10.1093/ecco-jcc/jjad006

SARS-CoV-2 does not have a strong effect on the nasopharyngeal microbial composition

Autorzy: Tzipi Braun, Shiraz Halevi, Rotem Hadar, Gilate Efroni, Efrat Glick Saar, Natahan Keller, Amnon Amir, Sharon Amit, Yael Haberman
Opublikowane w: Scientific Reports, Numer 11, 2022, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-021-88536-6

Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort

Autorzy: Tzipi Braun, Rui Feng, Amnon Amir, Nina Levhar, Hila Shacham, Ren Mao, Rotem Hadar, Itamar Toren, Yadid Algavi, Kathleen Abu-Saad, Shuoyu Zhuo, Gilat Efroni, Alona Malik, Orit Picard, Miri Yavzori, Bella Agranovich, Ta-Chiang Liu, Thaddeus S. Stappenbeck, Lee Denson, Ofra Kalter-Leibovici, Eyal Gottlieb, Elhanan Borenstein, Eran Elinav, Minhu Chen, Shomron Ben-Horin, Yael Haberman
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-48106-6

Gut microbial signature in lung cancer patients highlights specific taxa as predictors for durable clinical benefit

Autorzy: Yael Haberman, Iris Kamer, Amnon Amir, Sapir Goldenberg, Gilat Efroni, Inbal Daniel-Meshulam, Anastasiya Lobachov, Sameh Daher, Rotem Hadar, Hadas Gantz-Sorotsky, Damien Urban, Tzipi Braun, Jair Bar
Opublikowane w: Scientific Reports, Numer 13, 2023, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-023-29136-4

Gut microbiome development in early childhood is affected by day care attendance

Autorzy: Amnon Amir, Ortal Erez-Granat, Tzipi Braun, Katya Sosnovski, Rotem Hadar, Marina BenShoshan, Sophia Heiman, Haya Abbas-Egbariya, Efrat Glick Saar, Gilat Efroni, Yael Haberman
Opublikowane w: npj Biofilms and Microbiomes, Numer 8, 2022, ISSN 2055-5008
Wydawca: Nature
DOI: 10.1038/s41522-021-00265-w

Tissue-based Gene Expression as Potential Biomarkers for IBD Course

Autorzy: Yael Haberman
Opublikowane w: Inflammatory Bowel Diseases, Numer 26/10, 2020, Strona(/y) 1485-1489, ISSN 1078-0998
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1093/ibd/izaa217