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Enhancing brain function and cognition via artificial entrainment of neural oscillations

Objective

Neural oscillations are ubiquitous in the human brain and have been implicated in diverse cognitive functions to support both neural communication and plasticity. Their functional relevance is further supported by a large number of studies linking various cognitive deficits (e.g. attention deficit hyperactivity disorder, ADHD) with abnormal neural oscillations. However, this field of research faces two important problems: First, there is only correlative, but no causal evidence linking cognitive deficits to abnormal neural oscillations in humans. Second, there is virtually no theory-driven mechanistic approach that generates insights into how oscillations within and across neural networks are linked to human behavior. In this project, I propose to take decisive steps to provide a long-needed neurophysiological characterization—via (1) computational modelling, (2) electrophysiological measures, and (3) novel non-invasive manipulations of cortical rhythms—on how neural oscillations contribute to two types of cognitive processes that are fundamental for many aspects of human behavior: attention and short-term memory. I will go a step further by demonstrating that it is possible to augment performance in these cognitive functions with the design of non-invasive brain stimulation protocols individually tailored to the theory-driven neurocomputational characterizations and electrophysiological signatures of each individual. This will result in the applied goal of deriving new neuro-computational assays that can detect deviant network interactions causally related to cognitive functions, which is key for then renormalizing those functions in neuropsychological conditions such as ADHD. Thus, if successful, my proposed work will ultimately result in novel, low-cost, and painless non-invasive neural interventions for a wide range of neuropsychological disorders tied to abnormal neural oscillations.

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

ERC-STG - Starting Grant

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2017-STG

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Host institution

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 497 104,00
Address
Raemistrasse 101
8092 Zuerich
Switzerland

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 497 104,00

Beneficiaries (1)

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